Product image of Kabiven (Valine, Alanine, Arginine, Histidine, Isoleucine, Leucine, Methionine, Phenylalanine, Proline, Serin) supplied by GNH India

Kabiven

Active Ingredient:
Valine, Alanine, Arginine, Histidine, Isoleucine, Leucine, Methionine, Phenylalanine, Proline, Serin
Origin:
EU

Kabiven (Valine, Alanine, Arginine, Histidine, Isoleucine, Leucine, Methionine, Phenylalanine, Proline, Serin)

Amino acid solution, the active ingredient in Kabiven, is a amino acid solution presented as a sterile solution for injection for intravenous use. It supplies essential amino acids required for protein synthesis and nitrogen balance, supporting the nutritional needs of patients who cannot receive enteral feeding, such as those in postoperative, trauma, or critical care settings.

GNH India supplies Kabiven as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide, with consistent quality and regulatory compliance.

Manufacturer / TM Owner

Fresenius Kabi Ab

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Indications & Clinical Uses

Kabiven is an amino acid solution used in parenteral nutrition to meet protein and nitrogen requirements when oral or tube feeding is not feasible.

  • Enteral feeding intolerance: provides necessary amino acids when oral or tube feeding is not possible.
  • Post‑operative recovery: helps meet protein requirements after surgery.
  • Critical illness or trauma: maintains nitrogen balance in severely ill patients.

How It Works

  • Kabiven delivers a balanced mixture of essential and non‑essential amino acids directly into the bloodstream, bypassing gastrointestinal absorption. The amino acids become substrates for protein synthesis, support nitrogen balance, and contribute to metabolic pathways such as gluconeogenesis and neurotransmitter production, thereby sustaining cellular function in patients receiving total parenteral nutrition.

Side Effects

Adverse reactions may occur with intravenous amino acid solutions.

Common Side Effects

  • Hyperglycemia: elevated blood glucose levels.
  • Electrolyte imbalance: disturbances in serum potassium, sodium or calcium.
  • Fluid overload: excess volume leading to edema.
  • Local irritation: redness or pain at the infusion site.
  • Mild nausea: transient gastrointestinal discomfort.

Serious or Rare Side Effects

  • Anaphylactic reaction: severe allergic response requiring immediate intervention.
  • Metabolic acidosis: significant drop in blood pH.
  • Severe hypernatremia: dangerously high sodium concentration.

Precautions & Warnings

When using Kabiven, clinicians should observe several safety measures.

  • Renal function: monitor serum creatinine and urea levels.
  • Liver function: assess hepatic enzymes as amino acid metabolism may be altered.
  • Electrolytes: check serum electrolytes regularly.
  • Glucose control: monitor blood glucose in diabetic patients.
  • Infusion rate: adjust to avoid fluid overload.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Kabiven may interact with other intravenous therapies; awareness of potential interactions is essential.

Major Interactions (Avoid)

  • Co‑administration with high‑dose lipid emulsions may cause precipitation.
  • Concurrent use with nephrotoxic antibiotics (e.g., aminoglycosides) can increase renal risk.

Moderate Interactions (Monitor Closely)

  • Simultaneous IV dextrose solutions may affect glucose balance.
  • Combined electrolyte solutions may require adjustment of electrolyte content.
  • Use with other nitrogen‑containing parenteral products may lead to excess nitrogen load.

Frequently Asked Questions

Kabiven is an amino acid solution administered intravenously as part of total parenteral nutrition. It provides essential and non‑essential amino acids to patients who cannot receive nutrition through the gastrointestinal tract, such as those in postoperative, trauma, or intensive care settings.

The amino acids in Kabiven are directly available in the bloodstream, serving as building blocks for protein synthesis and supporting nitrogen balance. They also participate in metabolic pathways like gluconeogenesis and neurotransmitter production, helping maintain cellular function when enteral feeding is not possible.

The dose of Kabiven is individualized. A qualified prescriber determines the volume and rate based on the patient’s weight, clinical condition, and nutritional requirements, following institutional protocols for total parenteral nutrition.

The safety of Kabiven in pregnancy or lactation has not been fully established. Use is generally reserved for situations where the benefits outweigh potential risks, and it should be prescribed by a specialist familiar with maternal‑fetal considerations.

To order Kabiven, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements), and necessary import documentation.

Kabiven offers a comprehensive blend of essential and non‑essential amino acids in a single sterile solution, matching the amino acid profile recommended for adult total parenteral nutrition. Compared with products that provide separate amino acid modules, Kabiven simplifies preparation and reduces the risk of mixing errors, while delivering comparable nutritional support.

Kabiven should be stored at 2‑8 °C in a refrigerator, protected from light. Do not freeze or shake the vial. Before use, inspect the solution for particulate matter or discoloration and allow it to reach room temperature if required by the administration protocol.

Kabiven is administered intravenously as a sterile solution for injection. It is typically infused through a central venous catheter or a peripheral line, using an infusion pump to control the rate according to the prescribed total parenteral nutrition regimen.

Serious risks include anaphylactic reactions, metabolic acidosis, and severe electrolyte disturbances such as hypernatremia. Clinicians should monitor patients closely for signs of allergic response, acid‑base balance, and electrolyte levels throughout the infusion.

Kabiven is contraindicated in patients with known hypersensitivity to any of its amino acid components, those with uncontrolled severe electrolyte abnormalities, or individuals for whom total parenteral nutrition is not indicated. Clinical judgment should guide use in patients with severe hepatic or renal impairment.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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