Product image of Kabiven (Valine, Alanine, Arginine, Histidine, Isoleucine, Leucine, Methionine, Phenylalanine, Proline, Serin) supplied by GNH India

Kabiven

Active Ingredient:
Valine, Alanine, Arginine, Histidine, Isoleucine, Leucine, Methionine, Phenylalanine, Proline, Serin
Origin:
EU

Kabiven (Valine, Alanine, Arginine, Histidine, Isoleucine, Leucine, Methionine, Phenylalanine, Proline, Serin)

Valine, the active ingredient in Kabiven, is a parenteral nutrition presented as a solution for injection for intravenous use. It provides a balanced mixture of essential amino acids to support protein synthesis and maintain nitrogen balance in patients who cannot receive enteral feeding, such as those postoperative, trauma, or critically ill.

GNH India supplies Kabiven as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres and clinics worldwide.

Manufacturer / TM Owner

Fresenius Kabi Ab

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Indications & Clinical Uses

Kabiven is employed in parenteral nutrition to meet protein and nitrogen requirements across several clinical scenarios.

  • Patients unable to receive enteral feeding: supplies essential amino acids to sustain nutrition.
  • Post‑operative, trauma or critically ill patients: supports recovery by providing building blocks for tissue repair.
  • Catabolic states: helps maintain nitrogen balance and prevents muscle wasting.

How It Works

  • Kabiven delivers a defined blend of essential amino acids directly into the bloodstream, bypassing the gastrointestinal tract. The amino acids become substrates for protein synthesis, replenish intracellular pools, and contribute to the maintenance of nitrogen balance. By providing these building blocks, the solution supports cellular repair, immune function, and metabolic needs during periods when oral or enteral nutrition is not feasible.

Side Effects

Kabiven may be associated with infusion‑related and metabolic adverse reactions.

Common Side Effects

  • Phlebitis or infusion site erythema
  • Mild hypernatremia
  • Transient metabolic alkalosis
  • Elevated serum urea nitrogen
  • Mild hyperglycemia
  • Temporary increase in serum triglycerides

Serious or Rare Side Effects

  • Hypersensitivity reactions including anaphylaxis
  • Severe electrolyte disturbances (e.g., hyperkalemia, hypocalcemia)
  • Hyperammonemia
  • Acute renal insufficiency
  • Severe metabolic acidosis
  • Pulmonary edema from fluid overload

Precautions & Warnings

When using Kabiven, clinicians should observe several safety measures.

  • Assess renal function: adjust infusion rate in renal impairment.
  • Monitor electrolytes: check serum levels regularly during therapy.
  • Evaluate hepatic status: consider reduced clearance in liver disease.
  • Use aseptic technique: prevent contamination of the intravenous line.
  • Avoid in patients with known hypersensitivity to any component of the solution.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Kabiven can interact with other therapies; awareness of the interaction level guides management.

Major Interactions (Avoid)

  • Concurrent high‑dose amino acid solutions: may cause osmolar overload and fluid imbalance.
  • Co‑administration with nephrotoxic drugs: can exacerbate renal stress.

Moderate Interactions (Monitor Closely)

  • Insulin therapy: amino acids may affect glucose control, requiring dose adjustments.
  • Diuretics: may alter electrolyte balance, necessitating close monitoring.
  • Other parenteral nutrition components: compatibility testing is recommended to prevent precipitation.

Frequently Asked Questions

Kabiven is an amino acid solution for parenteral nutrition. It is administered intravenously to patients who cannot receive enteral feeding, such as those who are postoperative, trauma victims, or critically ill, providing essential building blocks for protein synthesis and nitrogen balance.

Valine, together with the other essential amino acids in Kabiven, serves as a substrate for protein synthesis. By delivering these amino acids directly into the bloodstream, the solution supports cellular repair, maintains nitrogen balance, and helps meet metabolic demands when oral intake is not possible.

The dose of Kabiven is individualized. The prescribing clinician determines the volume and rate based on the patient’s nutritional needs, weight, renal and hepatic function, and overall clinical condition. No fixed regimen is provided in the product information.

Safety data for Kabiven in pregnancy and lactation are limited. It should only be used when the potential benefit to the mother outweighs any possible risk to the fetus or infant, and the decision must be made by the treating physician.

To order Kabiven, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed) and import documentation.

Kabiven offers a balanced blend of ten essential amino acids in a single sterile solution, meeting European pharmacopeia standards. Compared with multi‑component kits, it simplifies preparation, reduces compatibility concerns, and provides consistent amino‑acid ratios, though clinicians may choose alternative formulations based on specific patient requirements.

Kabiven must be stored at 2‑8 °C, protected from light, and kept in its original container. Do not freeze or shake the solution. Before use, inspect for particulate matter or discoloration and ensure aseptic handling during preparation and administration.

Kabiven is administered intravenously as a sterile solution for injection. It is typically infused through a dedicated line or compatible infusion set, with the rate adjusted according to the patient’s nutritional prescription and monitored for tolerance and metabolic response.

Serious risks include hypersensitivity reactions such as anaphylaxis, severe electrolyte disturbances (e.g., hyperkalemia, hypocalcemia), hyperammonemia, and fluid overload leading to pulmonary edema. Prompt recognition and appropriate medical intervention are essential if these events occur.

Kabiven should be avoided in patients with known hypersensitivity to any of its amino‑acid components, in those with uncontrolled severe electrolyte imbalances, or in individuals where fluid overload poses a high risk. Clinical judgment is required for patients with severe renal or hepatic impairment.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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