Kabiven (Valine, Alanine, Arginine, Histidine, Isoleucine, Leucine, Methionine, Phenylalanine, Proline, Serin)

Kabiven is used in parenteral nutrition to deliver a complete profile of essential amino acids for patients who cannot be fed enterally.

• Parenteral nutrition for patients unable to receive enteral feeding: supplies the full complement of amino acids needed for protein synthesis.
• Post‑operative nutritional support: aids tissue repair and recovery after surgery.
• Critical‑care patients requiring amino acid supplementation: meets heightened metabolic demands during intensive care.

• Kabiven contains a balanced mixture of essential and non‑essential amino acids that are directly infused into the bloodstream. The amino acids are taken up by cells and incorporated into newly synthesized proteins, supporting nitrogen balance, tissue repair, and metabolic functions during periods when oral or enteral nutrition is not possible.

Kabiven may be associated with infusion‑related reactions and metabolic changes.

Common Side Effects

• Hyperglycemia: elevated blood glucose levels during infusion.
• Electrolyte imbalance: alterations in serum potassium, sodium, or calcium.
• Mild nausea or vomiting.
• Infusion site irritation or phlebitis.
• Increased blood urea nitrogen.
• Metabolic alkalosis.

Serious or Rare Side Effects

• Anaphylactic reaction: severe allergic response requiring immediate treatment.
• Severe hyperosmolarity: high osmolar load causing neurologic symptoms.
• Hepatic dysfunction: abnormal liver enzyme elevations.
• Metabolic acidosis.
• Severe electrolyte disturbances (e.g., hyperkalemia).
• Thrombophlebitis or catheter‑related bloodstream infection.

When using Kabiven, clinicians should consider patient‑specific factors and monitor relevant parameters.

• Renal impairment: assess renal function and adjust infusion rate as needed.
• Electrolyte disorders: check serum electrolytes before and during therapy.
• Hyperglycemia risk: monitor blood glucose, especially in diabetic patients.
• Infection risk: maintain strict aseptic technique during preparation and administration.
• Compatibility: verify compatibility with other intravenous solutions before mixing.
• Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Kabiven can interact with other intravenous agents and systemic therapies.

Major Interactions (Avoid)

• Concurrent high‑dose potassium chloride solutions: may cause dangerous hyperkalemia.
• Co‑administration with other amino‑acid formulations: risk of excess nitrogen load.
• Use with nephrotoxic drugs: may exacerbate renal dysfunction.

Moderate Interactions (Monitor Closely)

• Insulin therapy: glucose load may require insulin dose adjustment.
• Diuretics: monitor electrolyte balance closely.
• Blood transfusions: observe for changes in plasma osmolarity.