Product image of Kabiven (Valine, Alanine, Arginine, Histidine, Isoleucine, Leucine, Methionine, Phenylalanine, Proline, Serin) supplied by GNH India

Kabiven

Active Ingredient:
Valine, Alanine, Arginine, Histidine, Isoleucine, Leucine, Methionine, Phenylalanine, Proline, Serin
Origin:
EU

Kabiven (Valine, Alanine, Arginine, Histidine, Isoleucine, Leucine, Methionine, Phenylalanine, Proline, Serin)

Amino acid solution for parenteral nutrition, the active ingredient in Kabiven, is an amino acid solution presented as a solution for injection for intravenous use. It provides essential and non‑essential amino acids to support protein synthesis and nitrogen balance in patients receiving parenteral nutrition.

GNH India supplies Kabiven as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide.

Manufacturer / TM Owner

Fresenius Kabi Nv/Sa

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Indications & Clinical Uses

  • Kabiven is used in parenteral nutrition to provide amino acids for patients who cannot receive enteral feeding.
  • Parenteral nutrition for patients unable to receive enteral feeding: Supplies essential amino acids to maintain nitrogen balance.
  • Critically ill patients requiring protein synthesis support: Enhances tissue repair and recovery.
  • Postoperative nutritional support: Assists in wound healing and metabolic stability.

How It Works

  • Kabiven delivers a balanced mixture of essential and non‑essential amino acids directly into the bloodstream. The amino acids serve as substrates for protein synthesis, replenish nitrogen stores, and support metabolic pathways involved in tissue repair and immune function. By bypassing the gastrointestinal tract, the solution ensures rapid availability of nutrients in patients who cannot tolerate enteral feeding.

Side Effects

Kabiven may be associated with a range of infusion‑related reactions.

Common Side Effects

  • Hyperglycemia: Elevated blood glucose levels during infusion.
  • Electrolyte imbalance: Shifts in serum potassium, sodium, or calcium.
  • Phlebitis at infusion site: Local irritation or inflammation.
  • Mild nausea: Transient gastrointestinal discomfort.

Serious or Rare Side Effects

  • Anaphylactic reaction: Severe allergic response requiring immediate intervention.
  • Metabolic acidosis: Accumulation of acidic metabolites.
  • Severe hyperosmolarity: High osmolar load leading to fluid shifts.
  • Renal impairment: Deterioration of kidney function in susceptible patients.

Precautions & Warnings

  • When using Kabiven, clinicians should observe several safety measures.
  • Renal function: Assess creatinine clearance before initiation.
  • Electrolyte monitoring: Check serum levels regularly during therapy.
  • Fluid balance: Adjust infusion rate to avoid overload.
  • Metabolic disorders: Monitor for hyperammonemia or acidosis.
  • Compatibility: Do not mix with incompatible solutions.
  • Store at 2-8°C: Keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Kabiven can interact with other intravenous agents and systemic therapies.

Major Interactions (Avoid)

  • Calcium‑containing solutions: May precipitate amino acids.
  • High‑dose glucose infusions: Increase risk of hyperglycemia.

Moderate Interactions (Monitor Closely)

  • Loop diuretics: May affect electrolyte balance.
  • Corticosteroids: Can increase protein catabolism.
  • Insulin therapy: May require dose adjustment.

Frequently Asked Questions

Kabiven is an amino acid solution used in parenteral nutrition to provide essential and non‑essential amino acids to patients who cannot receive enteral feeding, supporting protein synthesis, nitrogen balance, and overall metabolic needs.

The solution delivers a balanced blend of amino acids directly into the bloodstream, supplying substrates for protein synthesis, replenishing nitrogen stores, and supporting metabolic pathways essential for tissue repair and immune function without requiring gastrointestinal absorption.

The prescribed dose of Kabiven is individualized by the treating clinician based on the patient’s nutritional requirements, renal function, and overall clinical condition. Dosage is calculated to meet specific protein and nitrogen targets.

Safety data for Kabiven in pregnancy and lactation are limited. It should only be used if the potential benefit to the mother outweighs any possible risk to the fetus or infant, and the decision must be made by a qualified healthcare professional.

To order Kabiven, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain where applicable), and necessary import documentation.

Kabiven offers a comprehensive profile of essential and non‑essential amino acids in a single formulation, matching the amino acid composition recommended for critically ill patients. Compared with some alternatives that may require mixing multiple solutions, Kabiven simplifies preparation and reduces the risk of incompatibility.

Kabiven should be stored at 2‑8 °C, kept refrigerated, protected from light, and must not be frozen or shaken. Use aseptic technique when preparing the infusion and ensure the container remains sealed until use.

Kabiven is administered intravenously as a solution for injection. It is typically infused through a dedicated IV line, with the rate adjusted according to the patient’s fluid balance, metabolic needs, and clinical monitoring parameters.

Serious risks include anaphylactic reactions, metabolic acidosis, severe hyperosmolarity, and renal impairment. Prompt recognition of these events and immediate medical intervention are essential to mitigate potential harm.

Kabiven should be avoided in patients with known hypersensitivity to any component of the solution, severe renal failure without appropriate dose adjustment, or those with uncontrolled electrolyte disturbances that could be exacerbated by the infusion.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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