Product image of Kabiven (Valine, Alanine, Arginine, Histidine, Isoleucine, Leucine, Methionine, Phenylalanine, Proline, Serin) supplied by GNH India

Kabiven

Active Ingredient:
Valine, Alanine, Arginine, Histidine, Isoleucine, Leucine, Methionine, Phenylalanine, Proline, Serin
Origin:
EU

Kabiven (Valine, Alanine, Arginine, Histidine, Isoleucine, Leucine, Methionine, Phenylalanine, Proline, Serin)

Valine, Alanine, Arginine, Histidine, Isoleucine, Leucine, Methionine, Phenylalanine, Proline, Serine, the active ingredient in Kabiven, is a amino acid solution presented as a solution for injection for intravenous use. It provides essential amino acids for protein synthesis and nitrogen balance in patients who cannot receive enteral feeding, such as postoperative, critically ill, or malnourished individuals.

GNH India supplies Kabiven as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, clinics and other healthcare institutions worldwide.

Manufacturer / TM Owner

Fresenius Kabi Ab

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Indications & Clinical Uses

Kabiven is an amino acid solution used in parenteral nutrition to support protein synthesis and nitrogen balance.

  • Parenteral nutrition for patients unable to receive enteral feeding: supplies essential amino acids to maintain nitrogen balance.
  • Postoperative or critically ill patients: helps meet increased metabolic demands and supports wound healing.
  • Management of malnutrition when oral intake is insufficient: provides a complete amino acid profile to prevent catabolism.

How It Works

  • Kabiven delivers a balanced mixture of essential and non‑essential amino acids directly into the bloodstream via intravenous infusion. These amino acids serve as substrates for protein synthesis, support tissue repair, immune function, and help maintain a neutral nitrogen balance, bypassing the need for gastrointestinal absorption.

Side Effects

Kabiven may be associated with infusion‑related adverse reactions and metabolic disturbances.

Common Side Effects

  • Hyperglycemia: elevated blood glucose levels during infusion.
  • Electrolyte imbalance: changes in potassium, sodium, or calcium concentrations.
  • Phlebitis: inflammation at the infusion site.
  • Nausea or vomiting: gastrointestinal discomfort.

Serious or Rare Side Effects

  • Metabolic acidosis: significant decrease in blood pH.
  • Hyperammonemia: elevated ammonia levels.
  • Severe allergic reaction: anaphylaxis or urticaria.
  • Renal impairment: worsening kidney function.

Precautions & Warnings

When using Kabiven, clinicians should observe several safety measures.

  • Patient assessment: evaluate renal and hepatic function before initiating therapy.
  • Electrolyte monitoring: check serum electrolytes regularly during infusion.
  • Blood glucose control: monitor glucose in diabetic or hyperglycemic patients.
  • Compatibility check: ensure solution is compatible with other IV fluids and medications.
  • Infusion rate: administer according to prescribed rate to avoid metabolic complications.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Kabiven can interact with other intravenous therapies and metabolic agents.

Major Interactions (Avoid)

  • High‑dose glucose solutions: may exacerbate hyperglycemia when co‑administered.
  • Nephrotoxic drugs: concurrent use can increase risk of renal impairment.

Moderate Interactions (Monitor Closely)

  • Electrolyte‑containing IV fluids: may cause additive electrolyte disturbances.
  • Diuretics: can alter fluid and electrolyte balance during therapy.
  • Insulin therapy: may require dose adjustments due to changes in glucose levels.

Frequently Asked Questions

Kabiven is an intravenous amino acid solution indicated for parenteral nutrition. It supplies essential amino acids to patients who cannot receive enteral feeding, such as those who are postoperative, critically ill, or suffering from severe malnutrition, helping to maintain protein synthesis and nitrogen balance.

The mixture provides the nine essential and non‑essential amino acids required for protein synthesis. When infused intravenously, the amino acids bypass the gastrointestinal tract, become directly available to cells, supporting tissue repair, immune function, and maintaining a neutral nitrogen balance in the body.

The dosage of Kabiven is individualized by the prescribing clinician based on the patient’s weight, metabolic needs, renal and hepatic function, and the overall nutrition plan. The healthcare professional determines the infusion volume and rate to achieve the desired amino acid intake.

Safety data for Kabiven in pregnancy and lactation are limited, and the product is generally reserved for situations where the benefits outweigh potential risks. Clinicians should assess the maternal and fetal condition carefully and consider alternative nutrition strategies when possible.

To place an order, submit an enquiry on the Kabiven product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details—including any cold‑chain requirements—and necessary import documentation.

Kabiven contains a balanced profile of ten amino acids that meets the European Pharmacopeia specifications for parenteral nutrition. Compared with some older formulations that may lack certain essential amino acids, Kabiven offers a more complete amino acid spectrum, potentially improving protein synthesis efficiency and reducing the need for supplemental individual amino acids.

Kabiven must be stored at 2‑8 °C in a refrigerator, protected from light, and must not be frozen or shaken. The container should remain in its original packaging until use, and any unused portion should be discarded according to local regulations after the recommended in‑use period.

Kabiven is administered intravenously as a sterile solution for injection. The infusion is typically given through a central or peripheral venous line, using a calibrated infusion pump or gravity drip, at a rate prescribed by the clinician. Compatibility with other IV fluids should be confirmed before mixing.

Serious risks include metabolic acidosis, hyperammonemia, severe allergic reactions such as anaphylaxis, renal impairment, and catheter‑related sepsis. Patients should be closely monitored for changes in blood pH, ammonia levels, kidney function, and signs of hypersensitivity throughout the infusion.

Kabiven is contraindicated in patients with known hypersensitivity to any of its amino acid components, those with severe hepatic failure where ammonia clearance is compromised, and individuals with uncontrolled electrolyte disturbances that cannot be corrected before therapy. Clinical judgment is required for patients with unstable renal function or severe metabolic disorders.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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