Product image of Kabiven (Valine, Alanine, Arginine, Histidine, Isoleucine, Leucine, Methionine, Phenylalanine, Proline, Serin) supplied by GNH India

Kabiven

Active Ingredient:
Valine, Alanine, Arginine, Histidine, Isoleucine, Leucine, Methionine, Phenylalanine, Proline, Serin
Origin:
EU

Kabiven (Valine, Alanine, Arginine, Histidine, Isoleucine, Leucine, Methionine, Phenylalanine, Proline, Serin)

Valine, Alanine, Arginine, Histidine, Isoleucine, Leucine, Methionine, Phenylalanine, Proline, and Serine, the active ingredients in Kabiven, are an amino acid solution presented as an intravenous solution for parenteral nutrition use. It provides essential amino acids to patients who cannot receive adequate oral or enteral intake.

GNH India supplies Kabiven as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Fresenius Kabi Ab

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Indications & Clinical Uses

  • Kabiven is an amino acid solution used in parenteral nutrition to meet protein and metabolic needs.
  • Parenteral nutrition for patients with inadequate oral or enteral intake: Supplies essential amino acids to support protein synthesis when enteral feeding is not possible.
  • Critical care or postoperative patients: Helps meet increased protein requirements during acute illness or after surgery.
  • Severe malnutrition: Contributes to nutritional rehabilitation by providing a balanced amino acid profile.

How It Works

  • Kabiven delivers a balanced mixture of essential and non‑essential amino acids directly into the bloodstream, bypassing the gastrointestinal tract. The amino acids become immediately available for protein synthesis, gluconeogenesis, and other metabolic pathways, thereby supporting tissue repair, immune function, and overall nitrogen balance in patients who cannot tolerate enteral nutrition.

Side Effects

Kabiven may be associated with a range of infusion‑related reactions.

Common Side Effects

  • Hyperglycemia: elevated blood glucose levels during infusion.
  • Electrolyte imbalance: shifts in potassium, sodium, or calcium concentrations.
  • Phlebitis: inflammation of the vein at the infusion site.
  • Infusion site reactions: redness, swelling, or discomfort.

Serious or Rare Side Effects

  • Anaphylactic reaction: severe allergic response requiring immediate medical attention.
  • Metabolic acidosis: significant drop in blood pH due to acid accumulation.
  • Hyperammonemia: elevated ammonia levels, especially in patients with hepatic impairment.

Precautions & Warnings

  • When using Kabiven, clinicians should observe several safety measures.
  • Renal impairment: adjust infusion volume and monitor renal function.
  • Hepatic dysfunction: monitor ammonia and liver enzymes.
  • Electrolyte monitoring: check serum electrolytes regularly.
  • Hyperglycemia risk: measure blood glucose during therapy.
  • Compatibility: ensure proper dilution and avoid mixing with incompatible solutions.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Kabiven can interact with other intravenous agents and systemic medications.

Major Interactions (Avoid)

  • Concurrent high‑dose potassium chloride: risk of precipitation.
  • Calcium‑containing solutions mixed directly: may cause insoluble calcium‑phosphate complexes.
  • Incompatible drugs (e.g., certain antibiotics) when combined in the same line.

Moderate Interactions (Monitor Closely)

  • Loop diuretics: may increase electrolyte loss.
  • Insulin therapy: may augment hypoglycemia risk.
  • Other parenteral nutrition components: monitor total nutrient and fluid load.

Frequently Asked Questions

Kabiven is an intravenous amino acid solution used as part of parenteral nutrition to provide essential amino acids to patients who cannot obtain adequate nutrition through oral or enteral routes, such as those in critical care, postoperative recovery, or severe malnutrition.

The amino acids in Kabiven are delivered directly into the bloodstream, making them immediately available for protein synthesis, energy production, and metabolic processes. This bypasses the gastrointestinal tract and helps maintain nitrogen balance and tissue repair in patients unable to eat or absorb nutrients.

The dose of Kabiven is individualized by the prescribing clinician based on the patient’s weight, metabolic needs, and clinical condition. Healthcare professionals calculate the appropriate volume and concentration to meet the patient’s protein and caloric requirements.

Safety data for Kabiven in pregnancy and lactation are limited. It should only be used if the potential benefits outweigh any potential risks, and the decision must be made by a qualified healthcare provider after careful assessment.

To order Kabiven, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed), and import documentation.

Kabiven offers a comprehensive blend of essential and non‑essential amino acids in a single intravenous formulation, matching the amino acid profile recommended for adult parenteral nutrition. Compared with products that provide separate amino acid modules, Kabiven simplifies preparation and reduces the risk of dosing errors.

Kabiven must be stored refrigerated at 2‑8 °C, protected from light, and should never be frozen or shaken. Before use, allow the solution to reach room temperature if required, and inspect for particulate matter or discoloration.

Kabiven is administered intravenously, typically through a central venous catheter or a peripheral line using an infusion pump. The infusion rate is set by the clinician according to the prescribed volume and the patient’s tolerance, with regular monitoring of vital signs and laboratory parameters.

Serious risks include anaphylactic reactions, metabolic acidosis, and hyperammonemia, especially in patients with liver dysfunction. Prompt recognition of symptoms such as difficulty breathing, rapid heart rate, or altered mental status is essential, and immediate medical intervention should be initiated.

Kabiven should be avoided in patients with known hypersensitivity to any of its amino acid components, severe renal or hepatic failure where amino acid clearance is compromised, and in those where compatible intravenous solutions cannot be ensured.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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