Product image of Kabiven (Valine, Alanine, Arginine, Histidine, Isoleucine, Leucine, Methionine, Phenylalanine, Proline, Serin) supplied by GNH India

Kabiven

Active Ingredient:
Valine, Alanine, Arginine, Histidine, Isoleucine, Leucine, Methionine, Phenylalanine, Proline, Serin
Origin:
EU

Kabiven (Valine, Alanine, Arginine, Histidine, Isoleucine, Leucine, Methionine, Phenylalanine, Proline, Serin)

Valine, Alanine, Arginine, Histidine, Isoleucine, Leucine, Methionine, Phenylalanine, Proline, Serine, the active ingredients in Kabiven, are an amino acid solution presented as a parenteral solution for injection for intravenous use. It provides essential amino acids to support protein synthesis and metabolic needs in patients requiring parenteral nutrition.

GNH India supplies Kabiven as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Fresenius Kabi Ab

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Indications & Clinical Uses

Kabiven is used in clinical situations where parenteral nutrition is required to maintain protein and nitrogen balance.

  • Inability to receive enteral feeding: provides a complete amino acid profile intravenously to meet nutritional needs.
  • Postoperative or critically ill state: supports protein synthesis and nitrogen balance during recovery.
  • Malabsorption or gastrointestinal dysfunction: supplies essential amino acids when intestinal absorption is compromised.

How It Works

  • Kabiven delivers a balanced mixture of essential and non‑essential amino acids directly into the bloodstream. These amino acids are taken up by cells and incorporated into new proteins, supporting tissue repair, enzyme production, and metabolic pathways. By bypassing the gastrointestinal tract, the solution ensures rapid availability of substrates for protein synthesis in patients who cannot be fed enterally.

Side Effects

Kabiven may be associated with infusion‑related and metabolic adverse reactions.

Common Side Effects

  • Infusion site erythema or pain.
  • Mild nausea or vomiting.
  • Transient hyperglycemia.
  • Electrolyte shifts such as mild hypernatremia.

Serious or Rare Side Effects

  • Severe allergic reaction (anaphylaxis).
  • Metabolic acidosis.
  • Thrombophlebitis at the catheter site.

Precautions & Warnings

When using Kabiven, clinicians should observe several safety measures.

  • Assess renal function: monitor serum creatinine and urea levels.
  • Monitor electrolytes: watch for hypernatremia, hyperkalemia, and calcium disturbances.
  • Check hepatic status: avoid in severe liver failure without adjustment.
  • Use aseptic technique: ensure sterile handling of the infusion set.
  • Avoid in patients with known hypersensitivity to any amino acid component.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Kabiven can interact with other therapies that affect electrolyte or metabolic balance.

Major Interactions (Avoid)

  • High‑dose potassium supplements: risk of hyperkalemia.
  • Concurrent sodium bicarbonate solutions: may cause precipitation.
  • Co‑administration with nephrotoxic antibiotics (e.g., aminoglycosides): increased renal risk.

Moderate Interactions (Monitor Closely)

  • Total parenteral nutrition containing high glucose: monitor blood glucose.
  • Loop or thiazide diuretics: observe fluid and electrolyte status.
  • Additional amino acid solutions: avoid duplication and excess nitrogen load.

Frequently Asked Questions

Kabiven is an intravenous amino acid solution used as part of total parenteral nutrition. It supplies essential amino acids to patients who cannot receive enteral feeding, such as those who are postoperative, critically ill, or have gastrointestinal malabsorption.

The amino acids in Kabiven are directly delivered into the bloodstream, where they are taken up by cells for protein synthesis, tissue repair, and metabolic processes. This bypasses the digestive system, ensuring rapid availability of nutrients for patients who cannot eat or absorb nutrients normally.

The dose of Kabiven is individualized by the prescribing clinician based on the patient’s weight, metabolic needs, and clinical condition. Dosage calculations consider factors such as protein requirements, renal and hepatic function, and overall fluid balance.

The safety of Kabiven in pregnancy or lactation has not been definitively established. It should only be used if the potential benefit to the mother outweighs any possible risk to the fetus or infant, and under close medical supervision.

To order Kabiven, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed), and import documentation.

Kabiven provides a balanced blend of ten essential amino acids in a single sterile solution, matching the composition recommended for adult parenteral nutrition. Compared with multi‑component TPN kits, Kabiven simplifies formulation by delivering a ready‑to‑use amino acid component, reducing preparation time and potential for mixing errors.

Kabiven must be stored at 2‑8 °C, protected from light, and must not be frozen or shaken. Keep the vial in its original packaging until use, and discard any solution that appears discolored or contains particulate matter.

Kabiven is administered intravenously as an infusion, typically added to a total parenteral nutrition bag or given as a separate amino‑acid infusion. The rate and volume are set by the prescribing clinician and monitored by the healthcare team to ensure appropriate nutrient delivery.

Serious risks include severe allergic reactions (anaphylaxis), metabolic acidosis, and thrombophlebitis at the infusion site. Patients should be monitored for signs of hypersensitivity, changes in acid‑base balance, and catheter‑related complications during and after infusion.

Kabiven should be avoided in patients with known hypersensitivity to any of its amino acid components, in those with uncontrolled hyperkalemia, and in individuals with severe hepatic failure unless dosage adjustments are made. Clinical judgment is required for each case.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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