Product image of Kabiven (Valine, Alanine, Arginine, Histidine, Isoleucine, Leucine, Methionine, Phenylalanine, Proline, Serin) supplied by GNH India

Kabiven

Active Ingredient:
Valine, Alanine, Arginine, Histidine, Isoleucine, Leucine, Methionine, Phenylalanine, Proline, Serin
Origin:
EU

Kabiven (Valine, Alanine, Arginine, Histidine, Isoleucine, Leucine, Methionine, Phenylalanine, Proline, Serin)

Valine, Alanine, Arginine, Histidine, Isoleucine, Leucine, Methionine, Phenylalanine, Proline, Serin, the active ingredients in Kabiven, are an amino acid solution presented as an intravenous solution for parenteral use. It supplies essential amino acids to support protein synthesis and metabolic functions in patients who cannot receive enteral feeding.

GNH India supplies Kabiven as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres and intensive‑care units worldwide. The company adheres to stringent quality standards and provides regulatory documentation for each batch.

Manufacturer / TM Owner

Fresenius Kabi Norge As

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Indications & Clinical Uses

  • Kabiven, an amino acid solution for parenteral nutrition, is used to meet protein and amino‑acid requirements in specific clinical situations.
  • Parenteral nutrition for patients unable to receive enteral feeding: Provides essential amino acids intravenously to maintain nitrogen balance and support metabolism.
  • Critical illness or postoperative care: Supplies substrates for protein synthesis during catabolic stress, helping preserve lean body mass.
  • Severe malnutrition where oral intake is insufficient: Delivers a complete profile of essential amino acids to prevent muscle wasting and support recovery.

How It Works

  • Kabiven contains a balanced mixture of essential amino acids that, when infused intravenously, enter the systemic circulation without the need for gastrointestinal absorption. The amino acids become available for hepatic and peripheral protein synthesis, replenish intracellular pools, and support gluconeogenesis and nitrogen balance. By directly supplying these building blocks, the solution facilitates tissue repair, immune function and metabolic stability in patients reliant on parenteral nutrition.

Side Effects

Kabiven may be associated with infusion‑related reactions and metabolic disturbances.

Common Side Effects

  • Phlebitis at the infusion site
  • Mild electrolyte imbalance (e.g., potassium, calcium)
  • Transient hyperglycemia
  • Nausea or mild gastrointestinal discomfort

Serious or Rare Side Effects

  • Anaphylactic or severe hypersensitivity reaction
  • Severe metabolic acidosis
  • Hyperammonemia leading to neurologic changes
  • Acute renal dysfunction or failure

Precautions & Warnings

  • When using Kabiven, clinicians should observe several safety considerations to minimize complications.
  • Renal impairment: Monitor renal function and adjust infusion rate as needed.
  • Liver disease: Assess hepatic function before initiation.
  • Electrolyte disturbances: Check serum electrolytes regularly during therapy.
  • Hyperglycemia risk: Monitor blood glucose in diabetic or pre‑diabetic patients.
  • Compatibility: Use only with compatible IV fluids and maintain aseptic technique.
  • Store at 2-8°C: Keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Kabiven can interact with certain intravenous solutions and systemic medications.

Major Interactions (Avoid)

  • Concurrent high‑dose potassium chloride: May cause precipitation.
  • Calcium‑containing solutions: Risk of calcium‑amino acid precipitation.
  • Alkaline IV solutions: Incompatible and may lead to precipitation.

Moderate Interactions (Monitor Closely)

  • Diuretics: May exacerbate electrolyte shifts.
  • Insulin therapy: Monitor glucose as amino acids can raise blood sugar.
  • Renal replacement therapy: May alter amino acid clearance and require dose adjustment.

Frequently Asked Questions

Kabiven is an intravenous amino acid solution used as part of parenteral nutrition. It provides essential amino acids to patients who cannot receive enteral feeding, supporting protein synthesis, nitrogen balance, and overall metabolic needs during critical illness, surgery, or severe malnutrition.

The mixture supplies a complete profile of essential amino acids directly into the bloodstream. These amino acids become substrates for hepatic and peripheral protein synthesis, replenish intracellular pools, support gluconeogenesis, and help maintain nitrogen balance, thereby aiding tissue repair and metabolic stability.

The dose of Kabiven is individualized by the prescribing clinician based on the patient’s weight, clinical condition, renal and hepatic function, and specific nutritional requirements. Dosing calculations follow established parenteral nutrition protocols and are adjusted according to laboratory monitoring.

The safety of Kabiven in pregnancy or lactation has not been definitively established. It should only be used if the potential benefits outweigh any potential risks, and the decision must be made by the treating physician in consultation with obstetric specialists.

To order Kabiven, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed) and any required import documentation.

Kabiven offers a balanced blend of ten essential amino acids in a single intravenous formulation, meeting European regulatory standards. Compared with some alternatives that may contain additional non‑essential amino acids or different concentration ratios, Kabiven is designed for broad applicability in critical‑care nutrition while maintaining compatibility with standard IV fluids.

Kabiven must be stored at 2‑8 °C in a refrigerator. Keep the container in its original packaging, protect it from light, and avoid freezing or shaking the solution. Do not use the product if it has been exposed to temperatures outside the recommended range.

Kabiven is administered intravenously, typically as a continuous infusion or via a controlled-rate pump, according to the prescribing clinician’s protocol. The solution is added to a compatible carrier fluid and infused through a central or peripheral venous line under aseptic conditions.

Serious risks include anaphylactic or severe hypersensitivity reactions, metabolic acidosis, hyperammonemia, and acute renal dysfunction. Prompt recognition of these events and immediate medical intervention are essential. Monitoring of vital signs, laboratory parameters and infusion site is recommended throughout therapy.

Kabiven should be avoided in patients with known hypersensitivity to any of its amino acid components, those with uncontrolled severe electrolyte disturbances, or individuals in whom intravenous amino acid administration is contraindicated due to specific metabolic disorders. Clinical judgment is required for each case.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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