Product image of Kabivit (Colecalciferol) supplied by GNH India

Kabivit

Active Ingredient:
Colecalciferol
Origin:
EU

Kabivit (Colecalciferol)

Colecalciferol, the active ingredient in Kabivit, is a vitamin D presented as a nutritional supplement for oral use. It helps correct vitamin D deficiency and supports calcium balance, bone mineralization, and overall skeletal health in children and adults at risk of hypocalcemia.

GNH India supplies Kabivit as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides reliable sourcing for health‑care providers across multiple regions, including Europe, Asia and Africa.

Manufacturer / TM Owner

Fresenius Kabi Hellas Single Member S.A.

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Indications & Clinical Uses

Kabivit (colecalciferol) is used to address disorders of vitamin D metabolism and related calcium imbalance.

  • Vitamin D deficiency: restores adequate serum 25‑hydroxyvitamin D levels to support normal calcium absorption.
  • Hypocalcemia: increases intestinal calcium absorption to raise serum calcium concentrations.
  • Bone health support: promotes bone mineralization and helps maintain skeletal integrity in at‑risk populations.

How It Works

  • Colecalciferol is converted in the liver to 25‑hydroxyvitamin D, which is further hydroxylated in the kidney to the active hormone 1,25‑dihydroxyvitamin D (calcitriol). Calcitriol binds to the vitamin D receptor in intestinal epithelial cells, enhancing transcription of calcium‑binding proteins and increasing absorption of calcium and phosphate, thereby facilitating bone mineralization. The increased mineral availability also supports remodeling processes and reduces secondary hyperparathyroidism.

Side Effects

Colecalciferol is generally well tolerated, but some individuals may experience adverse reactions.

Common Side Effects

  • Hypercalcemia: elevated blood calcium levels causing nausea or weakness.
  • Gastrointestinal discomfort: mild abdominal pain or constipation.
  • Headache: transient mild headache.

Serious or Rare Side Effects

  • Severe hypercalcemia: confusion, arrhythmia, or renal impairment.
  • Allergic reaction: rash, itching, or swelling of the face and throat.
  • Kidney stones: formation due to excess calcium.

Precautions & Warnings

When using Kabivit, certain precautions should be observed to ensure safety and effectiveness.

  • Assess baseline vitamin D status: measure serum 25‑hydroxyvitamin D before initiating therapy.
  • Monitor calcium levels: periodic testing is advised in patients at risk of hypercalcemia.
  • Avoid excessive dosing: high doses can lead to toxicity, especially in renal impairment.
  • Pregnancy and lactation: use only if prescribed after risk‑benefit evaluation.
  • Drug interactions: review concomitant medications that affect calcium or vitamin D metabolism.
  • Store at ambient temperature: keep below 25 °C in the original container, protect from moisture and light.

Avoid Interactions

Colecalciferol may interact with several medicines, altering its efficacy or safety.

Major Interactions (Avoid)

  • Thiazide diuretics: can increase risk of hypercalcemia when combined with high‑dose vitamin D.
  • Vitamin D analogues (e.g., calcitriol): concurrent use may cause excessive calcium levels.
  • Aluminum‑containing antacids: reduce absorption of vitamin D.

Moderate Interactions (Monitor Closely)

  • Orlistat: may decrease oral absorption of vitamin D, requiring dose adjustment.
  • Corticosteroids: can impair vitamin D metabolism, potentially reducing therapeutic effect.
  • Anticonvulsants (e.g., phenytoin, phenobarbital): increase vitamin D catabolism, possibly necessitating higher doses.

Frequently Asked Questions

Kabivit contains colecalciferol, a form of vitamin D3, and is used to treat vitamin D deficiency, manage hypocalcemia, and support overall bone health by improving calcium and phosphate absorption in the gastrointestinal tract.

Colecalciferol is converted in the liver to 25‑hydroxyvitamin D and then in the kidney to the active hormone calcitriol. Calcitriol binds to vitamin D receptors, stimulating the production of proteins that increase intestinal absorption of calcium and phosphate, which are essential for bone mineralization.

The appropriate dose of Kabivit is determined by a qualified health‑care professional based on the patient’s serum vitamin D level, age, weight, clinical condition, and any concurrent medications. Patients should follow the prescriber’s instructions and not adjust the dose on their own.

Colecalciferol is generally considered safe when prescribed during pregnancy or lactation, but the prescriber should evaluate the risk‑benefit ratio for each individual. Women who are pregnant or nursing should only use Kabivit if advised by their health‑care provider.

To order Kabivit, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Kabivit provides colecalciferol, the same active ingredient found in most vitamin D3 supplements. Compared with vitamin D2 (ergocalciferol), colecalciferol has a longer half‑life and is more effective at raising and maintaining serum 25‑hydroxyvitamin D levels, making it a preferred choice for many clinicians.

Kabivit should be stored at ambient temperature, preferably below 25 °C, in its original packaging. Protect the product from moisture, direct sunlight and excessive heat to maintain potency throughout its shelf life.

Kabivit is taken orally, usually as a tablet or capsule, with or without food as directed by the prescriber. The exact method of administration (e.g., with a glass of water) should follow the health‑care professional’s guidance.

The most serious risks include severe hypercalcemia, which can cause confusion, cardiac arrhythmias, and renal impairment, as well as rare allergic reactions such as facial swelling or difficulty breathing. Patients should seek immediate medical attention if these symptoms occur.

Kabivit should be avoided in individuals with known hypersensitivity to colecalciferol or any excipients, patients with active hypercalcemia, and those with certain rare metabolic disorders unless specifically directed by a physician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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