Product image of Kabivit (Colecalciferol) supplied by GNH India

Kabivit

Active Ingredient:
Colecalciferol
Origin:
EU

Kabivit (Colecalciferol)

Colecalciferol, the active ingredient in Kabivit, is a Vitamin D (secosteroid) presented as an oral dosage form for oral use. It is used to correct vitamin D deficiency, support calcium balance, and promote bone mineralization in children and adults at risk of low vitamin D levels.

GNH India supplies Kabivit as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company follows strict quality standards and provides regulatory documentation for import and distribution. Customers benefit from reliable logistics and post‑sale technical support.

Manufacturer / TM Owner

Fresenius Kabi Hellas Single Member S.A.

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Indications & Clinical Uses

  • Kabivit (colecalciferol) is employed in the management of disorders related to impaired vitamin D metabolism and calcium homeostasis.
  • Vitamin D deficiency: restores normal serum 25‑hydroxyvitamin D concentrations, improving bone health.
  • Hypocalcemia: increases intestinal calcium absorption to raise serum calcium levels.
  • Osteoporosis prevention: supports bone mineral density maintenance in at‑risk adults.
  • Bone health support: aids in the mineralization process for children and elderly patients.

How It Works

  • Colecalciferol is converted in the liver to 25‑hydroxyvitamin D, the major circulating form, and subsequently in the kidney to the active hormone 1,25‑dihydroxyvitamin D (calcitriol). Calcitriol binds to intracellular vitamin D receptors, forming a heterodimer with retinoid X receptors that regulates gene transcription, enhancing calcium and phosphate absorption from the gut and promoting bone mineralization. This pathway also modulates immune function and cell proliferation, contributing to its systemic effects.

Side Effects

Colecalciferol is generally well tolerated, but some users may experience adverse reactions.

Common Side Effects

  • Hypercalcemia: mild elevation of blood calcium levels causing fatigue or nausea.
  • Gastrointestinal discomfort: nausea, constipation or abdominal pain.
  • Headache: transient mild headache.
  • Dry mouth: sensation of oral dryness.

Serious or Rare Side Effects

  • Severe hypercalcemia: can lead to cardiac arrhythmia, renal impairment or calcification of soft tissues.
  • Hypercalciuria: excessive urinary calcium excretion increasing risk of kidney stones.
  • Allergic reaction: rash, itching, swelling or anaphylaxis in rare cases.

Precautions & Warnings

When using Kabivit, certain precautions should be observed to minimize risk and ensure effectiveness.

  • Monitor serum calcium: avoid hypercalcemia, especially in patients with renal disease.
  • Assess renal function: adjust use in chronic kidney disease.
  • Use caution in granulomatous diseases: conditions like sarcoidosis may increase active vitamin D levels.
  • Avoid excessive sun exposure combined with supplementation: may raise vitamin D excessively.
  • Store at room temperature: keep in the original container, protect from moisture and light.

Avoid Interactions

Colecalciferol may interact with other medicines, altering calcium balance or vitamin D metabolism.

Major Interactions (Avoid)

  • Thiazide diuretics: increase risk of hypercalcemia when combined with vitamin D.
  • Lithium: may potentiate hypercalcemia and affect calcium homeostasis.
  • High-dose vitamin A: synergistic effect raising calcium levels excessively.

Moderate Interactions (Monitor Closely)

  • Orlistat: reduces absorption of fat‑soluble vitamins, decreasing colecalciferol efficacy.
  • Anticonvulsants (phenytoin, phenobarbital): enhance hepatic metabolism, lowering vitamin D levels.
  • Corticosteroids: may diminish vitamin D activity, requiring monitoring.

Frequently Asked Questions

Kabivit contains colecalciferol, a form of vitamin D3, and is used to treat vitamin D deficiency, correct low blood calcium levels (hypocalcemia), and support bone health. It is commonly prescribed for individuals at risk of osteoporosis or those with conditions that impair calcium absorption.

Colecalciferol is converted in the liver to 25‑hydroxyvitamin D and then in the kidney to the active hormone calcitriol. Calcitriol binds to vitamin D receptors in target cells, stimulating the expression of proteins that increase intestinal absorption of calcium and phosphate, which are essential for bone mineralization.

The appropriate dose of Kabivit is determined by a qualified healthcare professional based on the patient’s age, serum vitamin D level, underlying condition, and individual response. Prescribers tailor the regimen to achieve optimal vitamin D status while avoiding excess calcium.

Vitamin D supplementation is generally considered safe during pregnancy and lactation when used at recommended levels. However, pregnant or nursing individuals should consult their physician before starting Kabivit to ensure the dose is appropriate for both mother and child.

To request Kabivit, visit the product page on gnhindia.com, enter the required quantity, and submit the enquiry form. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Kabivit provides colecalciferol, the natural form of vitamin D3, which is more potent and has a longer duration of action than vitamin D2 (ergocalciferol). Compared with high‑dose injectable preparations, Kabivit is an oral option that allows flexible dosing and is suitable for outpatient management.

Store Kabivit at room temperature, preferably below 25 °C. Keep the product in its original packaging, protect it from moisture, direct sunlight and extreme temperatures. Ensure the container is tightly closed to maintain stability and potency.

Kabivit is taken orally, usually with food to improve absorption of the fat‑soluble vitamin. The tablet or capsule should be swallowed whole with a glass of water unless otherwise directed by a healthcare professional.

The most serious adverse events are severe hypercalcemia and related complications such as cardiac arrhythmias, renal impairment or soft‑tissue calcification. Patients should be monitored for signs of elevated calcium, especially if they have kidney disease, granulomatous disorders or are taking interacting medications.

Kabivit should be avoided in individuals with known hypersensitivity to colecalciferol or any excipients, and in patients with hypercalcemia, hypervitaminosis D, or severe renal impairment unless closely supervised. Clinicians should also exercise caution in patients with sarcoidosis or other granulomatous diseases.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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