Product image of Kacital (Potassium Citrate) supplied by GNH India

Kacital

Active Ingredient:
Potassium Citrate
Origin:
EU

Kacital (Potassium Citrate)

Potassium Citrate, the active ingredient in Kacital, is a potassium salt presented as an oral formulation for oral use. It is employed to increase urinary pH and to correct metabolic acidosis in patients who require an alkalinizing agent.

GNH India supplies Kacital as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide.

Manufacturer / TM Owner

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Indications & Clinical Uses

Potassium Citrate acts as an alkalinizing agent to modify urinary chemistry and systemic acid‑base balance.

  • Calcium kidney stones: helps prevent stone formation by raising urinary citrate and pH.
  • Metabolic acidosis: corrects low blood bicarbonate levels in conditions such as renal tubular acidosis.
  • Urinary alkalinization: facilitates the dissolution of certain urinary crystals and improves the efficacy of some antimicrobial therapies.

How It Works

  • Potassium citrate dissociates to provide citrate ions, which are metabolized in the liver to bicarbonate. The resulting increase in systemic bicarbonate raises blood and urinary pH, creating an alkaline environment that reduces calcium stone formation and corrects metabolic acidosis.

Side Effects

Potassium Citrate may cause adverse reactions that vary in frequency and severity.

Common Side Effects

  • Gastrointestinal discomfort: nausea, abdominal cramping, or mild diarrhea.
  • Flatulence: increased gas production.
  • Taste alteration: a mild metallic or salty taste.
  • Hyperkalemia: elevated serum potassium, especially in renal impairment.

Serious or Rare Side Effects

  • Severe hyperkalemia: can lead to cardiac arrhythmias.
  • Metabolic alkalosis: excessive alkalinization of blood.
  • Allergic reactions: rash, itching, or swelling of the face and throat.

Precautions & Warnings

Before initiating therapy, consider patient‑specific factors and monitor appropriately.

  • Renal impairment: assess kidney function and adjust dose if needed.
  • Hyperkalemia risk: avoid in patients with high baseline potassium levels.
  • Concomitant potassium‑sparing drugs: monitor serum potassium closely.
  • Pregnancy and lactation: use only if the potential benefit justifies the potential risk.
  • Storage: Store below 25°C: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Potassium Citrate can influence the pharmacokinetics or pharmacodynamics of several medicines.

Major Interactions (Avoid)

  • Aluminum‑containing antacids: may bind citrate and reduce absorption.
  • ACE inhibitors or ARBs: can precipitate dangerous hyperkalemia.

Moderate Interactions (Monitor Closely)

  • Loop diuretics: may increase potassium loss, requiring electrolyte monitoring.
  • Sodium bicarbonate: additive alkalinizing effect may cause metabolic alkalosis.
  • Certain antibiotics (e.g., quinolones): urinary pH changes can affect drug activity.

Frequently Asked Questions

Kacital contains potassium citrate, which is used to prevent calcium‑based kidney stones, treat metabolic acidosis, and alkalinize urine in various clinical situations. It works by increasing urinary citrate and pH, creating conditions that reduce stone formation and correct acid‑base disturbances.

After oral administration, potassium citrate dissociates into potassium and citrate ions. The citrate is metabolized to bicarbonate in the liver, raising systemic and urinary pH. This alkalinizing effect increases citrate excretion, which binds calcium and helps prevent stone formation while also correcting low bicarbonate levels in metabolic acidosis.

The specific dose of Kacital is determined by the prescribing healthcare professional based on the individual’s condition, renal function, and laboratory values. Dosage may vary for stone prevention, metabolic acidosis, or urinary alkalinization, and should be followed as directed by the prescriber.

Safety data for potassium citrate in pregnancy and lactation are limited. It should only be used if the potential benefit outweighs any possible risk to the fetus or infant. Healthcare providers will evaluate the clinical situation before prescribing Kacital to pregnant or nursing individuals.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity of Kacital. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Kacital (potassium citrate) provides both potassium and citrate, offering dual benefits of potassium supplementation and urinary alkalinization. Compared with sodium bicarbonate, it avoids added sodium load, which can be advantageous for patients on sodium‑restricted diets. Its citrate component also directly inhibits calcium stone formation, a feature not shared by all alkalinizing agents.

Kacital should be stored at temperatures below 25 °C in its original packaging, protected from moisture and direct sunlight. Keep the container tightly closed and out of reach of children. No refrigeration is required for this oral formulation.

Kacital is taken orally, usually with a full glass of water. It may be taken with or without food, depending on the prescriber’s instructions. Patients should follow the dosing schedule provided by their healthcare professional and not exceed the prescribed amount.

The most serious risks include severe hyperkalemia, which can cause cardiac arrhythmias, and metabolic alkalosis from excessive alkalinization. Patients with impaired renal function or those taking other potassium‑raising medications are at higher risk and should be monitored closely.

Kacital should be avoided in individuals with known hypersensitivity to potassium citrate, severe renal impairment, or existing hyperkalemia. It is also contraindicated in patients taking medications that significantly raise serum potassium unless closely monitored by a healthcare professional.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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