Product image of Kadeflora (Lactobacillus Plantarum P 17630) supplied by GNH India

Kadeflora

Active Ingredient:
Lactobacillus Plantarum P 17630
Origin:
EU

Kadeflora (Lactobacillus Plantarum P 17630)

Lactobacillus plantarum P 17630, the active ingredient in Kadeflora, is a probiotic presented as a vaginal formulation for intravaginal use. It helps restore a healthy vaginal microbiota by colonising the vagina with beneficial lactobacilli, thereby supporting normal pH and inhibiting pathogenic organisms.

GNH India supplies Kadeflora as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, with distribution originating from the European Union market. The company ensures quality compliance with EU manufacturing standards and provides global logistics support.

Manufacturer / TM Owner

Dr. Kade Pharmazeutische Fabrik Gmbh

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Indications & Clinical Uses

Kadeflora is a vaginal probiotic that acts on the vaginal microbiome to promote a balanced bacterial environment.

  • Bacterial vaginosis: helps re‑establish lactobacilli dominance and may reduce recurrence after standard therapy.
  • Post‑antibiotic vaginal dysbiosis: restores normal flora following antibiotic treatment, supporting pH normalization.
  • Recurrent vulvovaginal candidiasis: may aid in maintaining a protective lactobacilli population to lower yeast overgrowth risk.

How It Works

  • Lactobacillus plantarum P 17630 colonises the vaginal epithelium, where it ferments glycogen to produce lactic acid, lowering the vaginal pH to ≤4.5. The acidic environment inhibits growth of pathogenic bacteria and yeast. Additionally, the strain secretes bacteriocins and hydrogen peroxide, which exert antimicrobial activity against Gardnerella, Escherichia coli and Candida species, thereby helping to restore a healthy microbiota.

Side Effects

Adverse reactions to Kadeflora are generally mild and related to local vaginal exposure.

Common Side Effects

  • Vaginal irritation: mild burning or stinging sensation.
  • Increased vaginal discharge: thin, white or off‑color discharge.
  • Itching or pruritus: mild localized itching.
  • Sensation of fullness: feeling of pressure in the vagina.

Serious or Rare Side Effects

  • Allergic reaction: rash, swelling, or hives.
  • Severe vaginal infection: signs of worsening infection despite use.
  • Systemic infection: rare cases of bacteremia in immunocompromised patients.
  • Anaphylaxis: rapid onset of breathing difficulty, hypotension.

Precautions & Warnings

Before using Kadeflora, consider the following precautions to ensure safe and effective use.

  • Pregnancy: safety has not been established; consult a healthcare professional before use.
  • Breastfeeding: limited data are available; discuss with a physician.
  • Immunocompromised patients: use with caution as rare systemic infection has been reported.
  • Concomitant antibiotic therapy: antibiotics may reduce probiotic efficacy; timing may need adjustment.
  • Store at ambient temperature: keep the product in its original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Kadeflora may interact with other agents that affect the vaginal microbiome or immune response.

Major Interactions (Avoid)

  • Systemic antibiotics: may eradicate the probiotic strain, negating its benefit.
  • Antifungal agents: concurrent use can diminish colonisation of Lactobacillus plantarum.

Moderate Interactions (Monitor Closely)

  • Immunosuppressive drugs: increased risk of opportunistic infection; monitor patient closely.
  • Hormonal contraceptives: no direct interaction, but hormonal changes can affect vaginal flora.
  • Vaginal douches or antiseptics: may disrupt probiotic colonisation; advise limited use.

Frequently Asked Questions

Kadeflora is a vaginal probiotic designed to restore and maintain a healthy vaginal microbiota. It is used to support normal pH balance, reduce the recurrence of bacterial vaginosis, aid recovery after antibiotic therapy, and help prevent recurrent vulvovaginal yeast infections by promoting beneficial lactobacilli growth.

The Lactobacillus plantarum strain in Kadeflora colonises the vaginal epithelium and ferments glycogen to produce lactic acid, which lowers the vaginal pH. The acidic environment suppresses pathogenic bacteria and yeast, while the strain also releases bacteriocins and hydrogen peroxide that directly inhibit harmful microorganisms, helping to re‑establish a balanced flora.

The dosage of Kadeflora is determined by the prescribing healthcare professional based on the individual’s condition and treatment plan. Specific dosing instructions, frequency, and duration should be obtained from the prescriber and are not provided here.

Safety data for Kadeflora in pregnancy and lactation are limited. Women who are pregnant or breastfeeding should discuss potential benefits and risks with their obstetrician or healthcare provider before initiating therapy.

To order Kadeflora, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and necessary import documentation.

Kadeflora contains the specific strain Lactobacillus plantarum P 17630, which is known for strong acid‑producing and bacteriocin‑secreting properties. Compared with other probiotic strains such as Lactobacillus rhamnosus or Lactobacillus reuteri, plantarum may offer a broader antimicrobial spectrum, though clinical outcomes can vary and should be evaluated by a clinician.

Kadeflora should be stored at ambient temperature, preferably below 25 °C, in its original packaging. Protect the product from moisture, direct sunlight and extreme temperature fluctuations to maintain bacterial viability throughout its shelf life.

Kadeflora is administered intravaginally. The product is typically inserted into the vagina using the supplied applicator or as directed by a healthcare professional. Administration should be performed in a clean environment, following the prescriber’s instructions regarding timing and frequency.

The most serious risks include rare allergic reactions such as rash, swelling, or anaphylaxis, and the potential for systemic infection (bacteremia) in severely immunocompromised individuals. Any signs of severe infection or allergic response should prompt immediate medical evaluation.

Kadeflora should be avoided by individuals with known hypersensitivity to Lactobacillus plantarum or any excipients in the formulation. It is also contraindicated in patients with severe immunosuppression unless specifically advised by a physician, and it should not be used without medical guidance during pregnancy or lactation.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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