Product image of Kadefungin 3 Kombi Packung (Clotrimazole) supplied by GNH India

Kadefungin 3 Kombi Packung

Active Ingredient:
Clotrimazole
Origin:
EU

Kadefungin 3 Kombi Packung (Clotrimazole)

Clotrimazole, the active ingredient in Kadefungin 3 Kombi Packung, is an imidazole antifungal presented as a topical preparation for cutaneous and vaginal use. It treats superficial fungal infections such as athlete’s foot, jock itch, and vaginal candidiasis in adults and children.

GNH India supplies Kadefungin 3 Kombi Packung as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides regulatory‑approved batches for global distribution, with full traceability and batch‑release documentation.

Manufacturer / TM Owner

Dr. Kade Pharmazeutische Fabrik Gmbh

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Indications & Clinical Uses

Clotrimazole is an imidazole antifungal used to treat superficial dermatophyte and yeast infections.

  • Tinea corporis: reduces erythema, scaling and itching associated with ringworm lesions on the body.
  • Tinea cruris: alleviates redness, irritation and burning sensations of jock itch affecting the groin and inner thigh.
  • Vulvovaginal candidiasis: clears yeast overgrowth, relieving discharge, itching and soreness in the vaginal area.

How It Works

  • Clotrimazole inhibits fungal ergosterol synthesis by binding to and blocking the cytochrome P450 enzyme lanosterol 14α‑demethylase. This disruption prevents formation of the cell membrane sterol ergosterol, leading to increased membrane permeability and ultimately fungal cell death, while having minimal effect on human cells.

Side Effects

Clotrimazole is generally well tolerated, but local skin reactions may occur.

Common Side Effects

  • Burning sensation at the application site
  • Itching or mild irritation
  • Redness or erythema
  • Dryness of the treated skin
  • Stinging feeling
  • Mild scaling

Serious or Rare Side Effects

  • Allergic contact dermatitis
  • Severe skin rash or urticaria
  • Swelling of the face, lips or tongue
  • Blistering or vesicular eruptions
  • Systemic hypersensitivity reactions
  • Angioedema

Precautions & Warnings

Before using Kadefungin 3 Kombi Packung, consider the following precautions.

  • Pregnancy: consult a healthcare professional before use.
  • Breastfeeding: discuss potential risks with a doctor.
  • Age: use with caution in children under two years of age.
  • Application: apply a thin layer only to affected skin, avoiding eyes, mucous membranes and broken skin.
  • Concomitant therapy: do not combine with other topical antifungal agents without medical advice.
  • Store at room temperature: keep in the original packaging, protect from moisture and direct heat.

Avoid Interactions

Clotrimazole may interact with other topical or systemic agents.

Major Interactions (Avoid)

  • Systemic azole antifungals (e.g., fluconazole) – may increase systemic exposure.
  • Topical corticosteroids – can reduce antifungal efficacy.

Moderate Interactions (Monitor Closely)

  • Alcohol‑based skin cleansers – may increase local irritation.
  • Other topical irritants (e.g., retinoids) – monitor for heightened skin reactions.
  • Antihistamines – may mask mild irritation, requiring observation.
  • Herbal skin preparations – assess for additive sensitisation risk.

Frequently Asked Questions

Kadefungin 3 Kombi Packung contains clotrimazole and is indicated for the topical treatment of superficial fungal infections such as tinea corporis (ringworm of the body), tinea cruris (jock itch) and vulvovaginal candidiasis (yeast infection of the vagina).

Clotrimazole blocks the fungal enzyme lanosterol 14α‑demethylase, a key step in ergosterol synthesis. Without ergosterol, the fungal cell membrane becomes unstable, leading to leakage of cellular contents and ultimately fungal cell death.

The specific dose and frequency are determined by the prescribing healthcare professional based on the infection type, severity and patient characteristics. Patients should follow the prescriber’s instructions and the product label.

Safety data for clotrimazole in pregnancy are limited. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss potential risks and benefits with their healthcare provider before using the product.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Clotrimazole is an imidazole antifungal with a broad spectrum against dermatophytes and yeasts. Compared with allylamine agents such as terbinafine, clotrimazole is often chosen for its wide availability, OTC status and effectiveness for both skin and vaginal infections, though the choice depends on the specific pathogen and clinical scenario.

Store the product at room temperature, below 25 °C, in its original packaging. Keep it away from excessive heat, direct sunlight and moisture to maintain product stability.

Apply a thin layer of the cream or ointment to the cleaned, dry affected area, usually twice daily or as directed by a healthcare professional. Avoid contact with eyes, mucous membranes and broken skin unless specifically advised.

Serious but rare risks include allergic reactions such as contact dermatitis, severe skin rash, swelling of the face or tongue, and systemic hypersensitivity. If any of these occur, discontinue use and seek immediate medical attention.

Individuals with a known hypersensitivity to clotrimazole or any component of the formulation should avoid using the product. Caution is also advised for patients with extensive broken skin, severe eczema or those using other topical antifungal agents without medical guidance.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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