Product image of Kadekliman (Dry Extract From Black Cohosh (4,5-8,5:1), Extraction Solvent: Ethanol 60% V/V) supplied by GNH India

Kadekliman

Active Ingredient:
Dry Extract From Black Cohosh (4,5-8,5:1), Extraction Solvent: Ethanol 60% V/V
Origin:
EU

Kadekliman (Dry Extract From Black Cohosh (4,5-8,5:1), Extraction Solvent: Ethanol 60% V/V)

Black cohosh dry extract, the active ingredient in Kadekliman, is a herbal presented as a dry extract for oral use. It is traditionally employed to alleviate menopausal symptoms in adult women, such as hot flashes and night sweats.

GNH India supplies Kadekliman as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides regulatory documentation for global distribution. Customers benefit from reliable supply chains, batch traceability, and responsive technical support.

Manufacturer / TM Owner

Dr. Kade Pharmazeutische Fabrik Gmbh

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Indications & Clinical Uses

Kadekliman, a black cohosh dry extract, is used to address symptoms associated with menopause.

  • Hot flashes: reduction in frequency and intensity of sudden heat sensations.
  • Night sweats: decreased episodes of excessive sweating during sleep.
  • Mood swings: improvement in emotional stability and reduction of irritability.
  • Sleep disturbances: support for more restful and uninterrupted sleep.

How It Works

  • Black cohosh dry extract is thought to exert its effects through modulation of serotonergic pathways and possible weak estrogenic activity, influencing hypothalamic thermoregulatory centers. The exact molecular targets remain incompletely defined, but the extract may interact with central neurotransmitters that regulate vasomotor and mood-related symptoms associated with menopause.

Side Effects

Adverse reactions have been reported with oral black cohosh preparations.

Common Side Effects

  • Gastrointestinal upset: mild nausea or abdominal discomfort.
  • Headache: transient mild to moderate pain.
  • Dizziness: occasional light‑headed sensation.
  • Skin rash: mild erythema or itching.
  • Fatigue: feeling of tiredness without exertion.

Serious or Rare Side Effects

  • Liver injury: signs of hepatitis or elevated liver enzymes.
  • Severe allergic reaction: swelling, difficulty breathing, or anaphylaxis.
  • Blood pressure changes: sudden hypertension or hypotension.
  • Thromboembolic events: rare clot formation.
  • Mood alterations: rare severe depression or anxiety.

Precautions & Warnings

When considering Kadekliman, several safety measures should be observed.

  • Pregnancy: safety not established; avoid use during pregnancy.
  • Breastfeeding: insufficient data; use with caution.
  • Liver disease: avoid if hepatic impairment is present.
  • Hormone‑sensitive conditions: discuss with a healthcare professional before use.
  • Drug interactions: inform prescriber of all concurrent medications.
  • Store at ambient temperature: keep in the original container, protect from moisture and light.

Avoid Interactions

Black cohosh may interact with certain medicines; monitoring is advised.

Major Interactions (Avoid)

  • Hormone replacement therapy: may increase estrogenic effects.
  • Anticoagulants (e.g., warfarin): potential for enhanced bleeding risk.
  • Selective serotonin reuptake inhibitors (SSRIs): possible serotonergic interaction.

Moderate Interactions (Monitor Closely)

  • Cytochrome P450 substrates: black cohosh may alter drug metabolism.
  • Other herbal supplements with similar actions: combined effects on hormone pathways.
  • Diabetes medications: monitor blood glucose as herbal effects may influence levels.

Frequently Asked Questions

Kadekliman contains a dry extract of black cohosh and is used as an over‑the‑counter herbal product to help relieve common menopausal symptoms such as hot flashes, night sweats, mood swings, and sleep disturbances in adult women.

The black cohosh extract in Kadekliman is believed to act on serotonergic pathways and may exhibit weak estrogen‑like activity, influencing the hypothalamic centers that control body temperature and mood, thereby reducing vasomotor and emotional symptoms of menopause.

The appropriate dose of Kadekliman is determined by the prescribing healthcare professional based on individual needs, product formulation, and local regulatory guidance. Patients should follow the dosage instructions provided by their clinician or the product label.

Safety of black cohosh during pregnancy has not been established, and its use is generally discouraged. For breastfeeding women, data are limited; therefore, it is recommended to consult a healthcare provider before using Kadekliman while nursing.

To order Kadekliman, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Kadekliman is an herbal option that differs from hormone replacement therapy (HRT) by not containing synthetic hormones. While HRT directly replaces estrogen, black cohosh may provide symptom relief through indirect modulation of hormonal pathways, offering a non‑hormonal alternative for women who cannot or prefer not to use HRT.

Kadekliman should be stored at ambient temperature, preferably below 25 °C, in its original packaging. Keep the container tightly closed, protect it from moisture, excessive heat, and direct sunlight to maintain product stability.

Kadekliman is taken orally, typically as a tablet or capsule, according to the dosage prescribed by a healthcare professional. It should be swallowed with water and taken with or without food as directed on the label or by the prescriber.

Serious risks, though rare, include potential liver injury, severe allergic reactions such as anaphylaxis, and significant changes in blood pressure. Users should seek immediate medical attention if they experience jaundice, unexplained abdominal pain, swelling, difficulty breathing, or sudden hypertension.

Kadekliman should be avoided by individuals who are pregnant, have known liver disease, are taking anticoagulant therapy, have hormone‑sensitive conditions (e.g., certain cancers), or have a documented allergy to black cohosh. Consultation with a healthcare provider is essential before starting the product.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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