Product image of Kafenac (Aceclofenac) supplied by GNH India

Kafenac

Active Ingredient:
Aceclofenac
Origin:
EU

Kafenac (Aceclofenac)

Aceclofenac, the active ingredient in Kafenac, is a nonsteroidal anti-inflammatory drug (NSAID) presented as an oral tablet for oral use. It treats inflammatory and painful musculoskeletal conditions such as osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, acute musculoskeletal pain and dental pain, providing analgesic and anti‑inflammatory effects.

GNH India supplies Kafenac as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Almirall, S.A.

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Indications & Clinical Uses

Aceclofenac is indicated for inflammatory musculoskeletal disorders and related pain conditions.

  • Osteoarthritis: reduces joint pain and improves functional mobility.
  • Rheumatoid arthritis: alleviates joint inflammation and swelling.
  • Ankylosing spondylitis: relieves spinal pain and stiffness.
  • Acute musculoskeletal pain: provides rapid analgesia for injuries or strains.
  • Dental pain: controls postoperative dental discomfort.

How It Works

  • Aceclofenac exerts its therapeutic effect by reversibly inhibiting cyclooxygenase (COX‑1 and COX‑2) enzymes, which reduces the conversion of arachidonic acid to prostaglandins. Lower prostaglandin levels diminish inflammation, pain signaling, and fever responses in affected tissues, resulting in analgesic, anti‑inflammatory, and antirheumatic actions.

Side Effects

Adverse reactions may occur with Aceclofenac use and are categorized by frequency and severity.

Common Side Effects

  • Gastrointestinal discomfort or dyspepsia.
  • Nausea or vomiting.
  • Headache.
  • Dizziness.
  • Mild skin rash.
  • Elevated liver enzymes.

Serious or Rare Side Effects

  • Gastrointestinal ulceration or bleeding.
  • Severe hepatic injury.
  • Acute renal impairment.
  • Life‑threatening skin reactions such as Stevens‑Johnson syndrome.
  • Anaphylactic shock.
  • Cardiovascular events including myocardial infarction.

Precautions & Warnings

Before prescribing Aceclofenac, clinicians should consider several safety measures.

  • Assess gastrointestinal risk: evaluate history of ulcers or bleeding.
  • Monitor liver function: check hepatic enzymes periodically.
  • Evaluate renal function: adjust use in patients with impaired kidneys.
  • Use the lowest effective dose: limit duration to the shortest necessary period.
  • Avoid in known hypersensitivity: discontinue if allergic reactions develop.
  • Store at room temperature: keep in the original pack, protect from moisture.

Avoid Interactions

Aceclofenac can interact with other medicines, requiring careful management.

Major Interactions (Avoid)

  • Anticoagulants (e.g., warfarin): increased bleeding risk.
  • Other NSAIDs or aspirin: additive gastrointestinal toxicity.
  • Corticosteroids: heightened risk of ulceration.
  • Selective serotonin reuptake inhibitors (SSRIs): potential for bleeding.
  • ACE inhibitors or ARBs: may reduce renal perfusion.

Moderate Interactions (Monitor Closely):\n- Diuretics: possible reduction in antihypertensive effect.

  • Lithium: increased serum lithium levels.
  • Methotrexate: reduced clearance leading to toxicity.

Frequently Asked Questions

Kafenac, containing the NSAID aceclofenac, is prescribed for inflammatory joint disorders such as osteoarthritis and rheumatoid arthritis, for ankylosing spondylitis, for acute musculoskeletal injuries, and for postoperative dental pain. It helps reduce pain, swelling, and stiffness associated with these conditions.

Aceclofenac works by reversibly blocking cyclooxygenase‑1 and cyclooxygenase‑2 enzymes, which are key steps in the synthesis of prostaglandins. By lowering prostaglandin production, it diminishes inflammation, pain signaling, and fever, providing analgesic and anti‑inflammatory benefits.

The specific dose of Kafenac is determined by the prescribing healthcare professional based on the patient’s condition, age, weight, and overall health. Dosage regimens are individualized and should follow the prescriber’s instructions and local prescribing guidelines.

The safety of aceclofenac in pregnancy and lactation has not been definitively established. It should only be used if the potential benefit justifies the potential risk to the fetus or infant, and the decision must be made by a qualified healthcare provider.

To request Kafenac, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Aceclofenac is chemically related to diclofenac but is often reported to have a slightly better gastrointestinal tolerance profile. Like other NSAIDs, it provides analgesic and anti‑inflammatory effects, but clinicians may choose it when a patient requires effective pain relief with a potentially lower risk of stomach irritation.

Kafenac tablets should be stored at room temperature, below 25 °C, in the original packaging to protect them from moisture and light. Keep the product out of reach of children and avoid storing in humid or excessively hot environments.

Kafenac is taken orally, usually with a full glass of water. It can be taken with or without food, although taking it with food may reduce gastrointestinal discomfort. Patients should follow the dosing schedule prescribed by their healthcare professional.

Serious risks include gastrointestinal ulceration or bleeding, severe liver injury, acute kidney damage, life‑threatening skin reactions such as Stevens‑Johnson syndrome, and increased cardiovascular events like heart attack or stroke. Patients should seek immediate medical attention if they experience symptoms such as severe abdominal pain, jaundice, swelling, or rash.

Kafenac should be avoided in individuals with known hypersensitivity to aceclofenac or other NSAIDs, those with active gastrointestinal ulcers, severe heart failure, uncontrolled hypertension, or significant liver or kidney disease. It is also contraindicated in patients taking certain anticoagulants or other NSAIDs without medical supervision.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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