Product image of Kaissan (Clopidogrel Hydrochloride) supplied by GNH India

Kaissan

Active Ingredient:
Clopidogrel Hydrochloride
Origin:
EU

Kaissan (Clopidogrel Hydrochloride)

Clopidogrel Hydrochloride, the active ingredient in Kaissan, is a P2Y12 receptor antagonist presented as an oral tablet for oral use. It reduces the risk of clot formation and is indicated for patients with acute coronary syndrome, prior myocardial infarction, stroke, or peripheral arterial disease. It is used in secondary prevention after myocardial infarction and in patients with established atherosclerotic disease.

GNH India supplies Kaissan as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies, and clinics worldwide, with a focus on quality assurance and regulatory compliance.

Manufacturer / TM Owner

Sandoz Farmacêutica Lda.

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Indications & Clinical Uses

Clopidogrel Hydrochloride is an antiplatelet agent that inhibits platelet aggregation in arterial thrombosis.

  • Acute coronary syndrome: reduces risk of recurrent cardiovascular events.
  • Post‑myocardial infarction secondary prevention: lowers incidence of new heart attacks.
  • Stroke prevention: decreases likelihood of recurrent ischemic stroke or transient ischemic attack.
  • Peripheral arterial disease: diminishes limb‑related ischemic events and need for revascularisation.

How It Works

  • Clopidogrel Hydrochloride is a pro‑drug that is metabolised by hepatic CYP enzymes, especially CYP2C19, to an active thiol metabolite. This metabolite binds irreversibly to the platelet P2Y12 ADP receptor, blocking ADP‑mediated activation of the GPIIb/IIIa complex and thereby preventing platelet aggregation and thrombus formation in arterial circulation.

Side Effects

Clopidogrel Hydrochloride may cause a range of adverse reactions.

Common Side Effects

  • Headache: mild to moderate headache reported.
  • Nausea: occasional feeling of nausea or upset stomach.
  • Diarrhoea: loose stools occurring in some patients.
  • Rash: mild skin irritation or rash.

Serious or Rare Side Effects

  • Severe bleeding: gastrointestinal or intracranial hemorrhage.
  • Thrombocytopenia: marked reduction in platelet count.
  • Hypersensitivity reactions: including angioedema, urticaria, or anaphylaxis.

Precautions & Warnings

When prescribing Clopidogrel Hydrochloride, consider the following precautions.

  • Assess bleeding risk: evaluate patient history for active or recent bleeding.
  • Monitor platelet count: periodic checks recommended during therapy.
  • Use caution in hepatic impairment: dose adjustment may be required.
  • Avoid concomitant NSAIDs or anticoagulants unless clinically necessary.
  • Discontinue before surgery: stop therapy as advised by the surgical team.
  • Store at ambient temperature: keep in the original pack, protect from moisture.

Avoid Interactions

Clopidogrel Hydrochloride interacts with several drug classes.

Major Interactions (Avoid)

  • Proton pump inhibitors (e.g., omeprazole): may reduce antiplatelet effect.
  • Anticoagulants (e.g., warfarin): increase risk of serious bleeding.
  • NSAIDs (e.g., ibuprofen): heighten bleeding tendency.

Moderate Interactions (Monitor Closely)

  • CYP2C19 inhibitors (e.g., fluconazole): may lower activation of clopidogrel.
  • CYP3A4 inhibitors (e.g., ketoconazole): can increase plasma levels.
  • Other antiplatelet agents (e.g., aspirin): monitor for additive bleeding risk.

Frequently Asked Questions

Kaissan contains clopidogrel hydrochloride, an antiplatelet medication used to reduce the risk of thrombotic cardiovascular events such as heart attack, stroke, and limb ischemia in patients with acute coronary syndrome, prior myocardial infarction, ischemic stroke, or peripheral arterial disease.

Clopidogrel is a pro‑drug that is converted in the liver to an active metabolite. This metabolite binds irreversibly to the platelet P2Y12 ADP receptor, blocking ADP‑mediated activation of the GPIIb/IIIa complex and preventing platelet aggregation, which reduces clot formation in arteries.

The appropriate dose of Kaissan is determined by the prescribing clinician based on the individual patient's medical condition, risk factors, and concomitant therapies. Dosage instructions are provided on the prescription label and should be followed exactly as directed.

The safety of clopidogrel during pregnancy or lactation has not been definitively established. It should only be used if the potential benefit justifies the potential risk to the fetus or infant, and the decision must be made by the treating physician.

To order Kaissan, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Kaissan (clopidogrel) is a P2Y12 receptor antagonist, whereas alternatives like aspirin inhibit cyclo‑oxygenase‑1. Clopidogrel provides more consistent platelet inhibition in patients who are aspirin‑resistant or require dual antiplatelet therapy, but it may have a higher cost and different interaction profile.

Kaissan should be stored at ambient temperature, below 25 °C, in its original packaging to protect it from moisture and light. Do not store in a humid environment or expose the tablets to excessive heat.

Kaissan is taken orally, usually as a whole tablet swallowed with water. It can be taken with or without food, but patients should follow the specific instructions provided by their healthcare professional.

The most serious risks include severe or life‑threatening bleeding, such as gastrointestinal or intracranial hemorrhage, and rare blood disorders like thrombocytopenia. Patients should seek immediate medical attention if they experience unusual bruising, bleeding, or signs of an allergic reaction.

Kaissan should not be used by patients with active pathological bleeding, severe liver disease, or known hypersensitivity to clopidogrel or any of its components. It is also contraindicated in individuals who have had a recent major surgery unless advised otherwise by a physician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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