Product image of Kalcium/Kolekalciferol Evolan (Colecalciferol, Calcium Carbonate) supplied by GNH India

Kalcium/Kolekalciferol Evolan

Active Ingredient:
Colecalciferol, Calcium Carbonate
Origin:
EU

Kalcium/Kolekalciferol Evolan (Colecalciferol, Calcium Carbonate)

Colecalciferol, the active ingredient in Kalcium/Kolekalciferol Evolan, is a vitamin D3 and calcium supplement presented as a nutritional supplement for oral use. It addresses calcium and vitamin D deficiencies and supports bone health in both adults and children.

GNH India supplies Kalcium/Kolekalciferol Evolan as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides reliable logistics for global distribution. With a focus on regulatory compliance, GNH India ensures product integrity throughout the supply chain.

Manufacturer / TM Owner

Evolan Pharma Ab

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Indications & Clinical Uses

Kalcium/Kolekalciferol Evolan is used to correct deficiencies in calcium and vitamin D, supporting skeletal health.

  • Calcium deficiency: helps restore normal calcium levels and promotes bone mineralization.
  • Vitamin D deficiency: provides vitamin D3 to enhance intestinal calcium absorption.
  • Bone health support: contributes to maintaining bone density in individuals at risk of osteopenia or osteoporosis.

How It Works

  • Colecalciferol (vitamin D3) is metabolized in the liver to 25‑hydroxyvitamin D and then in the kidney to the active hormone 1,25‑dihydroxyvitamin D, which binds to nuclear vitamin D receptors in intestinal epithelial cells, up‑regulating calcium‑transport proteins and increasing calcium absorption. Calcium carbonate supplies elemental calcium that dissolves in gastric acid and becomes available for incorporation into the bone matrix during remodeling.

Side Effects

Kalcium/Kolekalciferol Evolan may be associated with several adverse reactions, which are categorized by frequency and severity.

Common Side Effects

  • Hypercalcemia: elevated blood calcium causing fatigue, nausea, or mild weakness.
  • Gastrointestinal discomfort: abdominal pain, constipation, flatulence, or mild indigestion.
  • Headache: transient mild headache.
  • Metallic taste: occasional taste disturbance in the mouth.
  • Mild dizziness: occasional light‑headedness.

Serious or Rare Side Effects

  • Hypercalciuria: excessive urinary calcium excretion that can lead to kidney stone formation.
  • Severe allergic reaction: rash, itching, swelling, or anaphylaxis.
  • Hypervitaminosis D: toxicity from excess vitamin D resulting in soft‑tissue calcification.
  • Cardiac arrhythmia: rare but reported in cases of severe hypercalcemia.
  • Acute pancreatitis: very rare inflammatory response of the pancreas.

Precautions & Warnings

When using Kalcium/Kolekalciferol Evolan, certain precautions should be observed to ensure safety.

  • Assess baseline calcium and vitamin D levels: avoid supplementation if normal.
  • Monitor renal function: patients with kidney disease may accumulate calcium.
  • Review concomitant medications: especially thiazide diuretics or digitalis.
  • Limit use in hyperparathyroidism: risk of exacerbating hypercalcemia.
  • Avoid in known hypersensitivity to calcium carbonate or vitamin D3: discontinue if reaction occurs.
  • Store at ambient temperature: keep in original container, protect from moisture and direct sunlight.

Avoid Interactions

Kalcium/Kolekalciferol Evolan can interact with other medicines, requiring attention to avoid adverse outcomes.

Major Interactions (Avoid)

  • Thiazide diuretics: may increase risk of hypercalcemia.
  • Calcium channel blockers: can potentiate calcium‑related cardiac effects.
  • High‑dose vitamin A: synergistic hypercalcemia risk.

Moderate Interactions (Monitor Closely)

  • Bisphosphonates: concurrent use may affect calcium balance.
  • Anticonvulsants (e.g., phenobarbital, phenytoin): may reduce vitamin D effectiveness.
  • Corticosteroids: can impair calcium absorption, requiring dose adjustment.

Frequently Asked Questions

Kalcium/Kolekalciferol Evolan is an oral nutritional supplement that provides vitamin D3 (colecalciferol) and elemental calcium. It is intended to correct calcium and vitamin D deficiencies and to support normal bone mineralization and overall skeletal health in adults and children.

Colecalciferol is converted first in the liver to 25‑hydroxyvitamin D and then in the kidney to the active hormone 1,25‑dihydroxyvitamin D. This active form binds to vitamin D receptors in intestinal cells, stimulating the production of calcium‑transport proteins and thereby increasing the absorption of dietary calcium into the bloodstream.

The appropriate dose of Kalcium/Kolekalciferol Evolan is determined by a qualified healthcare professional based on the patient’s age, clinical condition, laboratory values and other individual factors. Prescribers set the regimen to achieve optimal calcium and vitamin D status while minimizing the risk of excess.

Vitamin D3 and calcium are essential nutrients during pregnancy and lactation, but the safety of any supplement depends on the dose and the mother’s existing nutritional status. Healthcare providers should evaluate the need for supplementation and prescribe an appropriate amount that aligns with current obstetric guidelines.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams across international markets. After the request, the sales team will verify trade or institutional credentials, then respond with pricing, availability, shipping details (including any cold‑chain requirements) and the necessary import documentation.

Kalcium/Kolekalciferol Evolan combines colecalciferol and calcium carbonate in a single oral formulation, offering a convenient source of both nutrients. Compared with products that contain separate vitamin D or calcium salts, this combination may simplify dosing and improve adherence, while providing comparable bioavailability when taken with food.

Store Kalcium/Kolekalciferol Evolan at ambient temperature, preferably below 25 °C. Keep the container tightly closed, protect it from moisture, heat and direct sunlight, and retain it in the original packaging until use to maintain product stability.

The supplement is taken orally, usually with a meal or a glass of water to enhance calcium absorption. Patients should follow the dosing instructions provided by their prescriber and avoid crushing or chewing tablets unless the formulation specifically permits it.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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