Product image of Kalciumfolinat Stada (Calcium Folinate) supplied by GNH India

Kalciumfolinat Stada

Active Ingredient:
Calcium Folinate
Origin:
EU

Kalciumfolinat Stada (Calcium Folinate)

Calcium folinate, the active ingredient in Kalciumfolinat Stada, is a folate analog presented as a sterile injectable solution for intramuscular or intravenous use. It is employed to rescue normal cells from the toxic effects of antifolate chemotherapy and to correct folate deficiency in patients receiving such treatment.

GNH India supplies Kalciumfolinat Stada as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, oncology centres and pharmacies worldwide.

Manufacturer / TM Owner

Stada Arzneimittel Ag

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Indications & Clinical Uses

Kalciumfolinat Stada provides reduced‑form folate to support patients in clinical situations where folate pathways are compromised.

  • Methotrexate toxicity rescue: restores folate‑dependent processes and reduces adverse effects of high‑dose methotrexate.
  • Folate deficiency: replenishes systemic folate stores in patients with inadequate dietary intake or malabsorption.
  • Adjunct in chemotherapy regimens: enhances tolerability of antifolate‑based protocols by protecting normal tissues.

How It Works

  • Calcium folinate is a reduced form of folic acid that bypasses dihydrofolate reductase inhibition. By entering cells directly, it restores the pool of tetrahydrofolate cofactors required for DNA synthesis, amino‑acid metabolism, and methylation reactions, thereby protecting normal cells from the cytotoxic effects of antifolate agents such as methotrexate.

Side Effects

Adverse reactions may occur with calcium folinate administration.

Common Side Effects

  • Nausea or vomiting
  • Transient headache
  • Mild injection site erythema
  • Low‑grade fever
  • Diarrhea
  • Elevated liver enzymes

Serious or Rare Side Effects

  • Severe hypersensitivity or anaphylaxis
  • Acute renal impairment
  • Significant neutropenia or thrombocytopenia
  • Pulmonary toxicity (interstitial pneumonitis)
  • Cardiac arrhythmias in patients with electrolyte disturbances
  • Unexplained bleeding or coagulopathy

Precautions & Warnings

When using calcium folinate, clinicians should observe several safety measures.

  • Renal function monitoring: adjust dosing in patients with impaired clearance.
  • Hepatic function monitoring: watch for elevated transaminases.
  • Hypersensitivity assessment: discontinue if severe allergic reaction occurs.
  • Concomitant high‑dose folate antagonists: avoid or adjust therapy.
  • Pregnancy and lactation: evaluate risk‑benefit before use.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze.

Avoid Interactions

Calcium folinate can interact with several medicines; awareness of the interaction level is essential.

Major Interactions (Avoid)

  • High‑dose methotrexate: may reduce rescue efficacy.
  • Trimethoprim‑sulfamethoxazole: competitive folate antagonism.
  • Phenytoin: may alter folate metabolism.

Moderate Interactions (Monitor Closely)

  • Non‑steroidal anti‑inflammatory drugs (NSAIDs): may affect renal clearance.
  • Penicillins (e.g., ampicillin): potential additive hematologic effects.
  • Anticonvulsants (e.g., carbamazepine): may increase folate requirement.

Frequently Asked Questions

Kalciumfolinat Stada contains calcium folinate, a reduced‑form folate used primarily to rescue patients from methotrexate‑induced toxicity, to treat folate deficiency, and as an adjunct in certain chemotherapy regimens that involve antifolate agents.

Calcium folinate bypasses the inhibition of dihydrofolate reductase caused by antifolate drugs, directly supplying tetrahydrofolate cofactors needed for DNA synthesis and cellular metabolism, thereby protecting normal cells while allowing chemotherapy to target malignant cells.

The appropriate dose of Kalciumfolinat Stada is determined by the prescribing clinician based on the specific indication, patient weight, renal function, and the chemotherapy protocol being used. Dosage instructions are provided on the prescription label.

Safety in pregnancy and lactation has not been definitively established. The prescriber should evaluate the potential benefits against possible risks before administering calcium folinate to pregnant or nursing women.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed) and import documentation.

Calcium folinate is a reduced‑form folate that acts more rapidly than oral folic acid supplements and provides a direct source of tetrahydrofolate. Compared with leucovorin, it offers similar rescue efficacy but may differ in formulation and stability, influencing storage and handling requirements.

Kalciumfolinat Stada should be stored at 2‑8 °C, protected from light, and kept in its original packaging. Do not freeze the product, and avoid shaking the vial to maintain solution integrity.

The product is administered by a healthcare professional via intramuscular or intravenous injection, according to the prescriber’s instructions and the clinical protocol being followed.

Serious risks include severe hypersensitivity reactions such as anaphylaxis, acute renal impairment, significant blood‑cell count reductions (neutropenia, thrombocytopenia), and rare pulmonary toxicity. Immediate medical attention is required if these events occur.

Patients with known hypersensitivity to calcium folinate or any excipients, those receiving high‑dose folate antagonists without medical supervision, and individuals with severe renal or hepatic impairment should avoid using this product unless specifically directed by a qualified clinician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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