Product image of Kalcizen (Colecalciferol, Calcium Carbonate) supplied by GNH India

Kalcizen

Active Ingredient:
Colecalciferol, Calcium Carbonate
Origin:
EU

Kalcizen (Colecalciferol, Calcium Carbonate)

Colecalciferol, the active ingredient in Kalcizen, is a vitamin D supplement presented as an oral tablet for oral use. It provides vitamin D3 together with calcium carbonate to support calcium absorption and bone health in adults and children with deficiency.

GNH India supplies Kalcizen as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Zentiva, K.S.

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Indications & Clinical Uses

Kalcizen is a combined vitamin D3 and calcium supplement that addresses calcium‑related metabolic pathways and bone health.

  • Osteoporosis: supports bone mineral density and helps reduce fracture risk.
  • Hypocalcemia: supplies calcium to correct low serum calcium levels.
  • Vitamin D deficiency: raises serum 25‑hydroxyvitamin D concentrations.
  • Post‑menopausal bone health: aids calcium absorption to maintain skeletal strength.

How It Works

  • Colecalciferol (vitamin D3) is converted in the liver to 25‑hydroxyvitamin D and then in the kidney to the active hormone calcitriol, which binds to vitamin D receptors in the intestine to increase transcription of calcium‑transport proteins, enhancing dietary calcium absorption. Calcium carbonate provides elemental calcium that is absorbed in the gastrointestinal tract, together restoring calcium homeostasis and supporting bone mineralization.

Side Effects

Kalcizen may cause adverse reactions, most of which are mild and reversible.

Common Side Effects

  • Nausea: mild stomach upset after ingestion.
  • Constipation: reduced bowel movements.
  • Flatulence: increased intestinal gas.
  • Hypercalcemia (mild): elevated serum calcium without symptoms.
  • Headache: occasional mild headache.

Serious or Rare Side Effects

  • Severe hypercalcemia: may cause confusion, cardiac arrhythmia, or renal impairment.
  • Kidney stones: calcium precipitation in the urinary tract.
  • Allergic reaction: rash, itching, or swelling.
  • Hypervitaminosis D: excessive vitamin D leading to toxicity.

Precautions & Warnings

Before initiating Kalcizen, consider the following precautions.

  • Assess calcium status: evaluate serum calcium levels to avoid excess.
  • Monitor vitamin D levels: check 25‑hydroxyvitamin D to guide supplementation.
  • Renal impairment: use with caution in patients with reduced kidney function.
  • Hypercalcemia: avoid in individuals with known high calcium levels.
  • Drug interactions: review concomitant medications that affect calcium balance.
  • Store below 25°C: keep in the original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Kalcizen can interact with other medicines that influence calcium or vitamin D metabolism.

Major Interactions (Avoid)

  • Thiazide diuretics: may increase risk of hypercalcemia.
  • Excess vitamin A: combined high intake can precipitate hypervitaminosis D.

Moderate Interactions (Monitor Closely)

  • Bisphosphonates: calcium may reduce their gastrointestinal absorption.
  • Corticosteroids: may increase vitamin D requirements.
  • Anticonvulsants (e.g., phenytoin): can lower vitamin D levels, reducing efficacy.

Frequently Asked Questions

Kalcizen is a combined vitamin D3 (colecalciferol) and calcium carbonate oral supplement used to support calcium absorption, maintain bone health, prevent osteoporosis, and treat calcium or vitamin D deficiency in adults and children.

Colecalciferol (vitamin D3) is converted in the liver to 25‑hydroxyvitamin D and then in the kidney to the active hormone calcitriol, which binds to vitamin D receptors in the intestinal lining, increasing the expression of calcium‑transport proteins and thereby enhancing dietary calcium absorption.

The appropriate dose of Kalcizen is determined by the prescribing healthcare professional based on the individual’s age, serum calcium and vitamin D levels, and clinical needs. Patients should follow the prescriber’s instructions and not adjust the dose on their own.

Kalcizen may be used during pregnancy or lactation when prescribed, as vitamin D and calcium are essential nutrients. However, the prescriber should evaluate the mother’s nutritional status and any potential risks before recommending supplementation.

To order Kalcizen, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and necessary import documentation.

Kalcizen combines colecalciferol and calcium carbonate in a single oral formulation, offering both vitamin D3 and elemental calcium. Compared with products that contain only calcium or only vitamin D, Kalcizen provides a synergistic effect on calcium absorption, which can be more convenient for patients needing both nutrients.

Store Kalcizen below 25 °C in its original packaging, protecting it from moisture and direct sunlight. Keep the container tightly closed and out of reach of children. No special refrigeration is required for this oral tablet.

Kalcizen is taken orally, usually with a glass of water. It can be taken with or without food, but some patients find it easier to swallow with meals to reduce gastrointestinal discomfort.

The most serious risks include severe hypercalcemia, which can cause confusion, cardiac arrhythmias, or kidney damage, and the formation of kidney stones. Rare allergic reactions such as rash, swelling, or anaphylaxis may also occur and require immediate medical attention.

Kalcizen should be avoided in individuals with known hypercalcemia, severe renal impairment, or a documented hypersensitivity to colecalciferol, calcium carbonate, or any excipients in the tablet. Patients with certain metabolic disorders should consult their physician before use.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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