Product image of Kaled (Calcifediol) supplied by GNH India

Kaled

Active Ingredient:
Calcifediol
Origin:
EU

Kaled (Calcifediol)

Calcifediol, the active ingredient in Kaled, is a vitamin D analog presented as an oral dosage form for oral use. It is used to treat vitamin D deficiency and to support bone health in adults at risk of osteomalacia or osteoporosis.
GNH India supplies Kaled as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

I.B.N. Savio S.R.L.

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Indications & Clinical Uses

Kaled, a vitamin D supplementation agent, addresses conditions related to insufficient vitamin D and bone mineralization.

  • Vitamin D deficiency: restores adequate serum 25‑hydroxyvitamin D levels.
  • Osteomalacia: improves bone mineralization and reduces bone pain.
  • Osteoporosis: supports calcium absorption to help maintain bone density.

How It Works

  • Calcifediol is the 25‑hydroxy form of vitamin D3. After oral absorption, it circulates in the bloodstream and is converted by 1‑α‑hydroxylase in the kidneys to the active hormone calcitriol. Calcitriol binds to vitamin D receptors in intestinal cells, enhancing transcription of calcium‑binding proteins, thereby increasing calcium and phosphate absorption and promoting bone mineralization.

Side Effects

Calcifediol is generally well tolerated, but some patients may experience adverse reactions.

Common Side Effects

  • Hypercalcemia: elevated blood calcium levels.
  • Hyperphosphatemia: increased phosphate concentrations.
  • Nausea: mild gastrointestinal discomfort.
  • Constipation: reduced bowel movements.
  • Headache: transient head pain.

Serious or Rare Side Effects

  • Nephrolithiasis: kidney stone formation.
  • Cardiac arrhythmia: irregular heart rhythm due to electrolyte imbalance.
  • Severe hypercalcemia: may cause confusion, muscle weakness, or renal impairment.
  • Allergic reaction: rash, itching, or swelling.
  • Pancreatitis: inflammation of the pancreas.

Precautions & Warnings

When using Kaled, consider the following safety measures.

  • Monitor serum calcium and phosphate: regular laboratory testing is advised.
  • Assess renal function: patients with kidney disease may require dose adjustment.
  • Evaluate for hyperparathyroidism: excess vitamin D can exacerbate the condition.
  • Avoid concurrent high‑dose calcium supplements: may increase risk of hypercalcemia.
  • Store at ambient temperature: keep below 25 °C, retain in original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Calcifediol may interact with several medicines, altering its effectiveness or safety.

Major Interactions (Avoid)

  • Thiazide diuretics: can potentiate hypercalcemia.
  • Vitamin D analogues (e.g., calcitriol): increase risk of excessive calcium levels.
  • Lithium: may enhance hypercalcemia risk.

Moderate Interactions (Monitor Closely)

  • Anticonvulsants (e.g., phenytoin, phenobarbital): may reduce vitamin D levels.
  • Corticosteroids: can impair vitamin D metabolism.
  • Orlistat: may decrease absorption of fat‑soluble vitamins.

Frequently Asked Questions

Kaled contains calcifediol, which is used to correct vitamin D deficiency and to support bone health in conditions such as osteomalacia and osteoporosis. It helps maintain adequate calcium and phosphate levels for proper bone mineralization.

Calcifediol is the 25‑hydroxy form of vitamin D3. After oral intake, it is converted in the kidneys to the active hormone calcitriol, which binds to vitamin D receptors in the intestine, enhancing calcium and phosphate absorption and promoting bone mineralization.

The appropriate dose of Kaled is determined by a qualified healthcare professional based on the patient’s serum vitamin D level, age, weight, and clinical condition. Prescribers set the dosage and regimen according to individual needs.

Safety data for calcifediol in pregnancy and lactation are limited. It should only be used if clearly needed and prescribed by a healthcare provider after evaluating the potential benefits and risks for both mother and child.

To order Kaled, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, and will request trade or institutional credentials before providing pricing, availability, shipping details and import documentation.

Kaled provides calcifediol, the 25‑hydroxy form of vitamin D3, which is more rapidly converted to the active hormone than cholecalciferol (vitamin D3). This can result in a quicker rise in serum 25‑hydroxyvitamin D levels, making it useful when a faster correction is desired.

Kaled should be stored at ambient temperature, below 25 °C. Keep the product in its original packaging, protect it from moisture, and store it away from direct sunlight to maintain stability.

Kaled is taken orally, usually with or without food, as directed by a healthcare professional. The tablet or capsule should be swallowed whole with a glass of water.

The most serious risks include severe hypercalcemia, which can cause confusion, muscle weakness, kidney stones, or cardiac arrhythmias. Patients should be monitored for elevated calcium levels, especially if they have kidney disease or are taking interacting medications.

Kaled should be avoided in individuals with known hypersensitivity to calcifediol or any excipients, in patients with severe hypercalcemia, and in those with certain disorders of calcium metabolism unless specifically prescribed by a physician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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