Product image of Kaliphos (Dipotassium Phosphate, Potassium Dihydrogen Phosphate) supplied by GNH India

Kaliphos

Active Ingredient:
Dipotassium Phosphate, Potassium Dihydrogen Phosphate
Origin:
EU

Kaliphos (Dipotassium Phosphate, Potassium Dihydrogen Phosphate)

Dipotassium Phosphate and Potassium Dihydrogen Phosphate, the active ingredients in Kaliphos, are an electrolyte solution presented as a solution for injection for intravenous use. It provides phosphate replacement and corrects electrolyte imbalances in patients who require intravenous therapy.

GNH India supplies Kaliphos as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide.

Manufacturer / TM Owner

Laboratoires Sterop

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Indications & Clinical Uses

Kaliphos is an intravenous electrolyte solution used to address conditions where phosphate and potassium balance are disrupted.

  • Phosphate replacement: restores serum phosphate levels in patients with hypophosphatemia.
  • Electrolyte imbalance correction: normalises potassium and phosphate concentrations during acute illness.
  • Peri‑operative management: supports metabolic needs of patients undergoing major surgery.

How It Works

  • Kaliphos delivers dipotassium phosphate and potassium dihydrogen phosphate directly into the bloodstream, supplying phosphate ions that participate in ATP synthesis, cellular signalling, and acid‑base regulation while providing potassium to maintain membrane potential and renal handling of electrolytes.

Side Effects

Kaliphos may cause a range of adverse reactions, most of which are related to rapid changes in serum electrolytes.

Common Side Effects

  • Hyperphosphatemia: elevated serum phosphate levels.
  • Hyperkalemia: increased potassium concentration.
  • Infusion site irritation: redness or discomfort at the catheter.
  • Mild hypotension: transient drop in blood pressure.
  • Nausea or headache.

Serious or Rare Side Effects

  • Severe hyperphosphatemia leading to calcium‑phosphate precipitation.
  • Cardiac arrhythmias due to electrolyte shifts.
  • Anaphylactic reaction: rash, bronchospasm, hypotension.
  • Metabolic acidosis.
  • Acute renal failure.

Precautions & Warnings

When using Kaliphos, clinicians should consider patient‑specific factors and monitor laboratory values.

  • Renal impairment: monitor serum phosphate and potassium closely.
  • Cardiac disease: watch for arrhythmias during infusion.
  • Pregnancy: use only if potential benefit justifies the risk.
  • Concomitant potassium supplements: avoid additive hyperkalemia.
  • Infusion rate: administer according to prescribed protocol to prevent rapid electrolyte shifts.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Kaliphos can interact with other medicines that affect phosphate or potassium balance.

Major Interactions (Avoid)

  • Calcium‑containing solutions: may precipitate phosphate and reduce efficacy.
  • Aluminum‑containing antacids: can bind phosphate and diminish replacement.
  • High‑dose vitamin D analogues: increase risk of severe hyperphosphatemia.

Moderate Interactions (Monitor Closely)

  • Loop diuretics: may enhance potassium loss.
  • ACE inhibitors or ARBs: can potentiate hyperkalemia.
  • Blood transfusions (citrate): may affect calcium and phosphate homeostasis.

Frequently Asked Questions

Kaliphos is an intravenous electrolyte solution used to replace phosphate and correct potassium‑related electrolyte imbalances in patients who cannot receive oral supplementation, such as those with severe hypophosphatemia, renal dysfunction, or undergoing major surgery.

Dipotassium phosphate dissociates after IV administration, releasing phosphate ions that participate in ATP production, cellular signalling, and acid‑base buffering, while also providing potassium to help maintain normal membrane potentials and renal electrolyte handling.

The dose of Kaliphos is determined by the prescribing clinician based on the patient’s serum phosphate and potassium levels, clinical condition, and renal function. The healthcare professional sets the appropriate volume and infusion rate.

Safety data for Kaliphos in pregnancy and lactation are limited. It should be used only if the expected benefit to the mother outweighs any potential risk to the fetus or infant, and the decision must be made by the treating physician.

To order Kaliphos, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed), and import documentation.

Kaliphos provides both dipotassium phosphate and potassium dihydrogen phosphate in a single IV formulation, offering simultaneous phosphate and potassium repletion. Compared with sodium‑based phosphate solutions, Kaliphos avoids additional sodium load, which can be advantageous in patients requiring fluid restriction.

Kaliphos should be stored at 2‑8 °C, protected from light, and kept in its original container. Do not freeze or shake the solution, and discard any product that appears cloudy or discoloured.

Kaliphos is administered intravenously by a qualified healthcare professional. The solution is typically infused through a peripheral or central line at a rate prescribed by the clinician, with continuous monitoring of vital signs and electrolyte levels.

Serious risks include severe hyperphosphatemia leading to calcium‑phosphate precipitation, life‑threatening cardiac arrhythmias from rapid electrolyte shifts, anaphylactic reactions, metabolic acidosis, and acute renal failure. Prompt recognition and management are essential.

Kaliphos is contraindicated in patients with known hypersensitivity to its components, uncontrolled hyperphosphatemia or hyperkalemia, and those with severe renal failure where phosphate accumulation cannot be safely managed. Clinicians should assess each patient individually.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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