Product image of Kaliumbromid Desitin (Potassium Bromide) supplied by GNH India

Kaliumbromid Desitin

Active Ingredient:
Potassium Bromide
Origin:
EU

Kaliumbromid Desitin (Potassium Bromide)

Potassium bromide, the active ingredient in Kaliumbromid Desitin, is a bromide presented as an oral formulation for oral use. It is used to manage seizure disorders, particularly epilepsy, in patients requiring adjunctive anticonvulsant therapy.

GNH India supplies Kaliumbromid Desitin as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Desitin Arzneimittel Gmbh

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Indications & Clinical Uses

Kaliumbromid Desitin (potassium bromide) is employed in the treatment of seizure disorders by enhancing neuronal inhibition.

  • Generalized tonic‑clonic seizures: reduces frequency and severity of convulsive episodes.
  • Partial (focal) seizures: provides adjunctive control when other agents are insufficient.
  • Refractory epilepsy: offers an alternative mechanism for patients unresponsive to standard therapies.

How It Works

  • Potassium bromide acts as a neuronal depressant that enhances gamma‑aminobutyric acid (GABA) mediated inhibition. By increasing the inhibitory tone in the central nervous system, it lowers neuronal excitability, which helps to suppress abnormal electrical activity associated with seizures. The precise molecular target is not fully defined, but the overall effect is a reduction in seizure propagation.

Side Effects

Potassium bromide may cause a range of adverse reactions, which vary in frequency and severity.

Common Side Effects

  • Drowsiness: mild to moderate sedation.
  • Ataxia: loss of coordination and balance.
  • Polyuria: increased urine output.
  • Polydipsia: excessive thirst.
  • Gastrointestinal upset: nausea or abdominal discomfort.
  • Skin rash: mild erythema or itching.

Serious or Rare Side Effects

  • Severe depression or mood changes.
  • Respiratory depression: difficulty breathing.
  • Hepatic dysfunction: elevated liver enzymes.
  • Blood dyscrasias: leukopenia or thrombocytopenia.
  • Anaphylactic reaction: sudden swelling, hives, or airway compromise.
  • Stevens‑Johnson syndrome: severe skin blistering.

Precautions & Warnings

When prescribing potassium bromide, clinicians should consider several safety measures.

  • Monitor serum bromide levels: ensure therapeutic range and avoid toxicity.
  • Assess renal function: impaired excretion can increase drug accumulation.
  • Evaluate hepatic status: liver disease may alter metabolism.
  • Avoid abrupt discontinuation: taper to prevent withdrawal seizures.
  • Check for hypersensitivity: discontinue if allergic reactions occur.
  • Store at ambient temperature: keep below 25°C in the original container, protected from moisture.

Avoid Interactions

Potassium bromide can interact with other medicines, requiring careful management.

Major Interactions (Avoid)

  • Phenobarbital: induces metabolism, reducing bromide efficacy.
  • Valproic acid: may increase bromide toxicity.
  • Carbonic anhydrase inhibitors (e.g., acetazolamide): raise bromide concentrations.

Moderate Interactions (Monitor Closely)

  • Other CNS depressants (e.g., benzodiazepines): enhanced sedation.
  • Diuretics: alter bromide excretion, affecting levels.
  • Alcohol: additive central nervous system depression.

Frequently Asked Questions

Kaliumbromid Desitin contains potassium bromide, an anticonvulsant used to control seizure disorders such as epilepsy. It is typically prescribed as an adjunct therapy when other antiepileptic drugs do not provide adequate seizure control.

Potassium bromide enhances the inhibitory action of the neurotransmitter GABA in the central nervous system. By increasing neuronal inhibition, it reduces the likelihood of abnormal electrical discharges that cause seizures, although the exact molecular target remains incompletely defined.

The dosage of potassium bromide is individualized and determined by the prescribing clinician based on the patient’s age, weight, seizure type, and serum bromide levels. Physicians adjust the dose to achieve therapeutic effect while minimizing toxicity.

Safety data for potassium bromide in pregnancy and lactation are limited, and the product’s pregnancy category is not established. Clinicians should weigh potential benefits against risks and consider alternative therapies when treating pregnant or nursing patients.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements), and necessary import documentation.

Potassium bromide offers a distinct mechanism by enhancing GABA‑mediated inhibition, which can be beneficial for patients who do not respond to sodium channel blockers or other classes. It is generally used as an adjunct rather than a first‑line agent, and its side‑effect profile differs, featuring more sedation and metabolic effects.

Store Kaliumbromid Desitin at ambient temperature, preferably below 25 °C. Keep the product in its original packaging, protect it from moisture, and avoid exposure to direct sunlight to maintain stability.

Kaliumbromid Desitin is taken orally, usually as a tablet or capsule, with or without food as directed by the prescriber. The exact administration schedule is individualized based on therapeutic response and serum bromide monitoring.

Serious risks include severe depression, respiratory depression, hepatic dysfunction, blood dyscrasias, and rare but life‑threatening allergic reactions such as anaphylaxis or Stevens‑Johnson syndrome. Patients should be monitored regularly for any signs of these adverse events.

Potassium bromide is contraindicated in individuals with known hypersensitivity to bromide salts, severe hepatic or renal impairment, and in patients where alternative, safer anticonvulsants are available. Clinicians should also avoid use in pregnant or lactating women unless the benefits clearly outweigh the risks.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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