Product image of Kalmente (Mometasone Furoate Anhydrous) supplied by GNH India

Kalmente

Active Ingredient:
Mometasone Furoate Anhydrous
Origin:
EU

Kalmente (Mometasone Furoate Anhydrous)

Mometasone furoate, the active ingredient in Kalmente, is a corticosteroid presented as a nasal spray for nasal use. It is indicated for the treatment of allergic rhinitis and nasal polyps in adults and children.
GNH India supplies Kalmente as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Zentiva, K.S.

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Indications & Clinical Uses

  • Mometasone furoate nasal spray acts on inflammatory pathways of the nasal mucosa to relieve symptoms of several upper‑respiratory conditions.
  • Allergic rhinitis: reduces nasal congestion, sneezing, itching and rhinorrhea.
  • Nasal polyps: decreases polyp size and improves nasal airflow.
  • Non‑allergic rhinitis: alleviates nasal obstruction and discharge.

How It Works

  • Mometasone furoate binds to intracellular glucocorticoid receptors, forming a complex that translocates to the nucleus and modulates gene transcription. This down‑regulates pro‑inflammatory cytokines, chemokines and adhesion molecules, leading to reduced vascular permeability, edema, and inflammatory cell infiltration in the nasal mucosa.

Side Effects

Mometasone furoate nasal spray may cause local and systemic adverse reactions.

Common Side Effects

  • Nasal irritation or burning sensation
  • Headache
  • Epistaxis (nosebleed)
  • Throat irritation or dryness
  • Cough
  • Altered taste or taste loss

Serious or Rare Side Effects

  • Nasal septal perforation
  • Adrenal suppression with prolonged use
  • Elevated intra‑ocular pressure, cataracts or glaucoma
  • Severe allergic reaction (anaphylaxis)
  • Opportunistic fungal infection of the nasal passages
  • Systemic corticosteroid effects such as hyperglycaemia

Precautions & Warnings

Before using Kalmente, consider the following safety measures.

  • Pregnancy: consult a healthcare professional as safety data are limited.
  • Lactation: discuss potential risks with a physician before use while breastfeeding.
  • Elderly patients: monitor for systemic corticosteroid effects due to altered metabolism.
  • Chronic ocular disease: assess intra‑ocular pressure regularly during prolonged therapy.
  • Long‑term use: evaluate for signs of adrenal suppression or nasal mucosal atrophy.
  • Store below 25°C: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Mometasone furoate nasal spray can interact with other medications.

Major Interactions (Avoid)

  • Systemic corticosteroids: increased risk of systemic glucocorticoid effects.
  • Strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole): may raise systemic exposure.
  • Live vaccines: potential reduction in vaccine efficacy.

Moderate Interactions (Monitor Closely)

  • Moderate CYP3A4 inhibitors (e.g., fluconazole, ritonavir): may modestly increase exposure.
  • Nasal decongestants: may enhance local irritation.
  • Antihistamines: additive sedation is uncommon but monitor patient comfort.

Frequently Asked Questions

Kalmente is a nasal spray containing mometasone furoate that is prescribed to treat allergic rhinitis and nasal polyps. It helps reduce nasal congestion, sneezing, itching, and can shrink nasal polyps to improve airflow.

Mometasone furoate binds to glucocorticoid receptors in nasal tissues, altering gene transcription to suppress the production of inflammatory cytokines and mediators. This reduces swelling, mucus production, and other inflammatory signs in the nasal passages.

The specific dose and frequency of Kalmente are determined by the prescribing healthcare professional based on the patient’s age, condition severity, and response to therapy. Patients should follow the prescriber’s instructions exactly.

Safety data for mometasone furoate nasal spray in pregnancy and lactation are limited. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss potential risks and benefits with their healthcare provider before using Kalmente.

To request Kalmente, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Kalmente (mometasone furoate) is a high‑potency intranasal corticosteroid with a favorable safety profile when used as directed. Compared with older agents such as beclomethasone, it offers once‑daily dosing and strong anti‑inflammatory activity, making it a preferred option for many clinicians.

Kalmente should be stored at temperatures below 25 °C, in its original packaging, protected from moisture and direct sunlight. Do not freeze the product, and keep the spray cap tightly closed when not in use.

Kalmente is administered as a nasal spray. The patient tilts the head slightly forward, inserts the nozzle into one nostril, and sprays the prescribed number of sprays while breathing in gently. The same procedure is repeated in the other nostril if directed by the prescriber.

Serious risks, though rare, include nasal septal perforation, adrenal suppression with prolonged high‑dose use, increased intra‑ocular pressure leading to glaucoma, and severe allergic reactions. Patients should report any unusual symptoms such as persistent nosebleeds, vision changes, or signs of systemic steroid effects.

Kalmente should be avoided in individuals with known hypersensitivity to mometasone furoate or any component of the formulation. Caution is also advised for patients with active untreated fungal, bacterial, or viral infections of the nasal passages, and those who have recently received live vaccines.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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