Product image of Kalms Night One-A-Night (Dry Extract Of Valerian Root, Extraction Solvent: Ethanol 60% V/V) supplied by GNH India

Kalms Night One-A-Night

Active Ingredient:
Dry Extract Of Valerian Root, Extraction Solvent: Ethanol 60% V/V
Origin:
EU

Kalms Night One-A-Night (Dry Extract Of Valerian Root, Extraction Solvent: Ethanol 60% V/V)

Valerian root extract, the active ingredient in Kalms Night One-A-Night, is a herbal sedative presented as a dry extract for oral use. It is intended to help adults who experience occasional sleep disturbances or difficulty falling asleep.
GNH India supplies Kalms Night One-A-Night as a licensed, GDP‑compliant international pharmaceutical supplier serving pharmacies and clinics worldwide.

Manufacturer / TM Owner

G R Lane Health Products Ltd.

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Indications & Clinical Uses

Kalms Night One-A-Night is an herbal sleep aid that acts on the central nervous system to promote relaxation and improve sleep quality.

  • Sleep disturbances: helps reduce the time needed to fall asleep and supports a more restful night.
  • Insomnia: may improve overall sleep duration and continuity in individuals with occasional insomnia.
  • Difficulty maintaining sleep: can aid in reducing nighttime awakenings and promote longer sleep periods.

How It Works

  • Valerian root extract contains valerenic acids and other constituents that are thought to modulate the GABAergic system. The compounds may enhance GABA release, inhibit its reuptake, and interact with adenosine receptors, leading to a mild depressant effect on neuronal activity that facilitates the onset of sleep without a clearly defined receptor binding profile.

Side Effects

Kalms Night One-A-Night is generally well tolerated, but some users may experience adverse reactions.

Common Side Effects

  • Headache: mild to moderate discomfort.
  • Dizziness: transient sensation of light‑headedness.
  • Gastrointestinal upset: nausea, stomach discomfort or mild diarrhoea.
  • Dry mouth: reduced salivation.
  • Fatigue: feeling of tiredness during the day.
  • Vivid dreams: unusually intense or memorable dreams.

Serious or Rare Side Effects

  • Allergic reaction: rash, itching, swelling, or difficulty breathing.
  • Liver enzyme elevation: abnormal liver function tests in rare cases.
  • Severe hypotension: unusually low blood pressure causing faintness.
  • Anaphylaxis: rapid, life‑threatening allergic response.
  • Skin reactions: Stevens‑Johnson syndrome or toxic epidermal necrolysis.
  • Psychiatric changes: rare reports of increased anxiety or depression.

Precautions & Warnings

When considering Kalms Night One-A-Night, several safety measures should be observed.

  • Pregnancy: safety not established; avoid use unless advised by a healthcare professional.
  • Breastfeeding: caution advised as the extract may pass into milk.
  • Concurrent CNS depressants: monitor for enhanced sedation when combined with alcohol, benzodiazepines, or antihistamines.
  • Elderly patients: increased risk of falls; start with the lowest effective dose.
  • Liver disease: use with caution in patients with known hepatic impairment.
  • Store at ambient temperature: keep in the original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Kalms Night One-A-Night may interact with other medicines that affect the central nervous system.

Major Interactions (Avoid)

  • CNS depressants (e.g., benzodiazepines, barbiturates, alcohol): risk of excessive sedation or respiratory depression.
  • Opioids: may potentiate sedative effects and impair psychomotor function.

Moderate Interactions (Monitor Closely)

  • Antidepressants (SSRIs, SNRIs): possible additive effects on sleep architecture.
  • Antihistamines: increased drowsiness.
  • Anticonvulsants (e.g., phenobarbital): potential alteration of seizure threshold.
  • Anticoagulants: theoretical risk of enhanced bleeding, though evidence is limited.

Frequently Asked Questions

Kalms Night One-A-Night is an over‑the‑counter herbal product containing valerian root extract. It is used to help adults who have occasional difficulty falling asleep, experience brief periods of insomnia, or suffer from mild sleep disturbances. The formulation is intended to promote relaxation and support a more natural sleep onset without prescription medication.

Valerian root extract contains valerenic acids and other phytochemicals that are believed to influence the GABAergic system in the brain. By enhancing GABA activity, reducing neuronal excitability, and interacting with adenosine receptors, the extract produces a mild calming effect that can shorten the time needed to fall asleep and improve overall sleep quality.

The appropriate dose of Kalms Night One-A-Night is determined by the prescribing healthcare professional based on individual needs, age, and health status. Patients should follow the specific instructions provided by their doctor or pharmacist and not exceed the recommended amount without medical guidance.

Safety data for valerian root extract in pregnancy and lactation are limited. It is generally advised that pregnant or breastfeeding women avoid using Kalms Night One-A-Night unless a qualified healthcare provider determines that the potential benefits outweigh any possible risks.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements), and assistance with import documentation.

Compared with synthetic hypnotics, Kalms Night One-A-Night offers a herbal alternative that may have a milder side‑effect profile and lower risk of dependence. However, its onset of action can be slower, and efficacy may vary between individuals. It is generally considered for mild to moderate sleep issues, whereas prescription agents are reserved for more severe insomnia.

Store Kalms Night One-A-Night at ambient temperature, preferably below 25 °C. Keep the product in its original packaging, protect it from moisture, direct sunlight, and extreme heat. Ensure the container is tightly closed to maintain product stability.

Kalms Night One-A-Night is taken orally, typically with a glass of water shortly before bedtime. The exact timing and amount should follow the prescriber's instructions. Swallow the tablet or capsule whole; do not crush or chew unless specifically directed.

Serious risks, though rare, include severe allergic reactions such as anaphylaxis, significant liver enzyme elevations, and marked hypotension leading to fainting. Users should seek immediate medical attention if they experience difficulty breathing, swelling of the face or throat, intense rash, or sudden drops in blood pressure.

Individuals with known hypersensitivity to valerian or any component of the formulation should avoid the product. It is also contraindicated for patients taking strong CNS depressants, those with severe liver disease, pregnant or breastfeeding women without medical advice, and anyone who has experienced serious adverse reactions to herbal sedatives.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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