Product image of Kanavit (Phytomenadione) supplied by GNH India

Kanavit

Active Ingredient:
Phytomenadione
Origin:
EU

Kanavit (Phytomenadione)

Phytomenadione, the active ingredient in Kanavit, is a Vitamin K presented as an injectable solution for intramuscular and intravenous use. It is employed to treat vitamin K deficiency, to prevent hemorrhage in newborns, and to reverse the anticoagulant effects of oral warfarin therapy.

GNH India supplies Kanavit as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide. The product conforms to EU quality standards and is distributed under strict regulatory oversight. It is available for institutional procurement across multiple regions.

Manufacturer / TM Owner

Bb Pharma A.S.

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Indications & Clinical Uses

Kanavit is used in clinical situations that involve impaired vitamin K–dependent coagulation pathways.

  • Vitamin K deficiency: restores normal clotting factor activity and reduces bleeding risk.
  • Newborn hemorrhage prevention: provides rapid vitamin K to newborns to prevent early‑life bleeding.
  • Warfarin therapy reversal: supplies vitamin K1 to counteract excessive anticoagulation and re‑establish hemostasis.

How It Works

  • Phytomenadione delivers vitamin K1 to hepatic cells, enabling the γ‑carboxylation of clotting factors II, VII, IX and X. This post‑translational modification restores the calcium‑binding capacity of the factors, allowing the coagulation cascade to proceed normally and correcting coagulopathy caused by vitamin K deficiency or antagonism.

Side Effects

Adverse reactions to Kanavit may vary in frequency and severity.

Common Side Effects

  • Injection site pain
  • Redness or swelling at the injection site
  • Headache
  • Nausea
  • Flushing
  • Transient fever

Serious or Rare Side Effects

  • Anaphylactic or severe allergic reaction
  • Thrombosis or excessive clot formation
  • Hemolysis
  • Hypotension or shock
  • Acute renal failure
  • Severe skin necrosis

Precautions & Warnings

When using Kanavit, several safety considerations should be observed.

  • Assess vitamin K status: evaluate baseline coagulation before administration.
  • Monitor coagulation parameters: check INR or PT after dosing.
  • Use caution in liver disease: impaired synthesis may affect response.
  • Avoid in known hypersensitivity: discontinue if allergic signs appear.
  • Adjust dose in neonates: follow pediatric guidelines.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Kanavit can interact with other medicines that affect coagulation or vitamin K metabolism.

Major Interactions (Avoid)

  • Concurrent use of other vitamin K antagonists (e.g., acenocoumarol, phenprocoumon).
  • Simultaneous administration of direct oral anticoagulants without appropriate reversal strategy.

Moderate Interactions (Monitor Closely)

  • Broad‑spectrum antibiotics (e.g., cephalosporins) that alter gut flora and vitamin K synthesis.
  • Lipid‑lowering agents (statins) that may affect vitamin K metabolism.
  • Oral contraceptives or hormone therapy influencing clotting balance.
  • Herbal supplements containing vitamin K (e.g., green leafy extracts).

Frequently Asked Questions

Kanavit is a prescription injectable vitamin K (phytomenadione) used to correct vitamin K deficiency, prevent bleeding in newborns, and reverse the anticoagulant effects of oral warfarin therapy in patients who require rapid restoration of normal clotting.

Phytomenadione provides vitamin K1, which is essential for the γ‑carboxylation of clotting factors II, VII, IX and X in the liver. This biochemical step restores the factors’ ability to bind calcium, enabling the coagulation cascade to function properly and stop bleeding.

The dose of Kanavit is determined by the prescribing clinician based on the patient’s clinical condition, laboratory results and route of administration. Healthcare professionals calculate the appropriate amount to achieve the desired reversal or correction of vitamin K status.

Safety data for Kanavit in pregnancy and lactation are limited. The product should only be used if the potential benefit justifies any potential risk to the fetus or infant, and the decision must be made by a qualified healthcare provider.

To request Kanavit, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain where required) and any necessary import documentation.

Kanavit delivers phytomenadione as an injectable formulation, offering rapid systemic availability compared with oral vitamin K tablets or syrups. This makes it especially suitable for emergency reversal of anticoagulation or immediate correction in newborns, whereas oral forms are generally used for routine supplementation.

Kanavit must be stored at 2‑8 °C in a refrigerator, protected from light. The vial should not be frozen or shaken. If the product must be transported, maintain the cold chain using validated insulated containers and temperature monitors.

Kanavit is administered by a qualified healthcare professional either intramuscularly or intravenously, depending on the clinical situation. The injection is given slowly to reduce the risk of adverse reactions, and patients are monitored for any immediate side effects.

Serious risks include anaphylactic or severe allergic reactions, thrombosis, hemolysis and hypotension. Prompt recognition of these events and immediate medical intervention are essential. Patients should be observed after administration, especially when given intravenously.

Kanavit should not be used in individuals with a known hypersensitivity to phytomenadione or any component of the formulation. Caution is also advised for patients with severe liver disease, uncontrolled bleeding disorders, or those who are pregnant or breastfeeding unless the benefit outweighs the risk.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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