Product image of Kanavit (Phytomenadione) supplied by GNH India

Kanavit

Active Ingredient:
Phytomenadione
Origin:
EU

Kanavit (Phytomenadione)

Phytomenadione, the active ingredient in Kanavit, is a Vitamin K presented as an oral tablet for oral use. It is used to treat vitamin K deficiency, prevent bleeding in newborns, and reverse anticoagulation caused by vitamin K antagonists.
GNH India supplies Kanavit as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Zentiva, K.S.

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Indications & Clinical Uses

Kanavit is a vitamin K agent that supports normal blood clotting pathways.

  • Vitamin K deficiency: restores adequate clotting factor activity to reduce bleeding risk.
  • Newborn prophylaxis: prevents hemorrhagic disease of the newborn by supplying essential vitamin K.
  • Anticoagulant reversal: counteracts the effects of warfarin and other vitamin K antagonists to normalize coagulation.

How It Works

  • Phytomenadione acts as a cofactor for the gamma‑carboxylation of glutamate residues in clotting factors II, VII, IX and X. This post‑translational modification enables the factors to bind calcium ions, which is essential for the assembly of the clotting complex and generation of thrombin, thereby restoring normal hemostasis.

Side Effects

Adverse reactions may occur with oral vitamin K therapy.

Common Side Effects

  • Bruising or mild bleeding at sites of minor trauma.
  • Nausea or mild gastrointestinal discomfort.
  • Transient headache.
  • Skin rash or mild pruritus.
  • Elevated liver enzymes (asymptomatic).

Serious or Rare Side Effects

  • Anaphylactic reaction (rare).
  • Severe hypersensitivity with angioedema.
  • Acute hemolysis in susceptible individuals.
  • Unexplained severe bleeding despite therapy.
  • Thromboembolic events in patients with underlying clotting disorders.

Precautions & Warnings

Kanavit should be used with clinical monitoring and awareness of patient‑specific factors.

  • Pregnancy: use only if the potential benefit outweighs the risk; consult a healthcare professional.
  • Breastfeeding: consider infant exposure; discuss with a clinician.
  • Liver disease: monitor coagulation parameters closely.
  • Concomitant anticoagulants: adjust dosing and monitor INR or PT.
  • Storage: Store below 25°C: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Phytomenadione may interact with several drug classes, requiring attention to dosing and monitoring.

Major Interactions (Avoid)

  • Warfarin or other vitamin K antagonists: may diminish anticoagulant effect.
  • Broad‑spectrum antibiotics (e.g., cephalosporins): can alter gut flora and affect vitamin K levels.
  • High‑dose vitamin E: may interfere with vitamin K–dependent clotting.

Moderate Interactions (Monitor Closely)

  • Statins (e.g., simvastatin): potential additive effect on liver enzymes.
  • Fibrates: may influence coagulation parameters.
  • Herbal supplements containing vitamin K (e.g., green leafy extracts): could reduce therapeutic need.

Frequently Asked Questions

Kanavit contains phytomenadione, a form of vitamin K, and is used to correct vitamin K deficiency, prevent bleeding in newborns, and reverse the anticoagulant effects of vitamin K antagonists such as warfarin. These indications are based on its role in supporting normal blood clotting.

Phytomenadione serves as a cofactor for the enzyme that adds a carboxyl group to specific glutamate residues in clotting factors II, VII, IX and X. This gamma‑carboxylation enables the factors to bind calcium, a critical step for assembling the clotting cascade and generating thrombin, thereby restoring hemostasis.

The appropriate dose of Kanavit is determined by the prescribing clinician based on the patient’s condition, age, weight, and laboratory values. Dosage regimens can vary widely, so the prescriber sets the exact amount and schedule for each individual case.

Kanavit may be used during pregnancy only if the potential benefit justifies any possible risk to the fetus, and it should be prescribed by a qualified healthcare professional. While limited data exist for breastfeeding, caution is advised and a clinician should evaluate the risk‑benefit balance for the infant.

To request Kanavit, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements), and necessary import documentation.

Kanavit provides phytomenadione in an oral dosage form, similar to other vitamin K1 (phytonadione) preparations. Compared with injectable forms, oral Kanavit offers convenient administration for outpatient settings but may have slower onset of action. Efficacy and safety profiles are comparable when used according to clinical guidelines.

Kanavit should be stored below 25 °C in its original packaging, protected from moisture and direct sunlight. Keep the product out of reach of children and avoid exposing it to extreme temperatures, which could affect potency.

Kanavit is taken orally, typically with water. The exact administration instructions, including whether it should be taken with food or on an empty stomach, are provided by the prescribing healthcare professional based on the individual treatment plan.

Serious risks, though rare, include anaphylactic reactions, severe hypersensitivity with angioedema, and unexpected severe bleeding despite therapy. Patients should seek immediate medical attention if they experience symptoms such as difficulty breathing, swelling of the face or throat, or sudden extensive bruising.

Kanavit is contraindicated in individuals with known hypersensitivity to phytomenadione or any excipients in the formulation. Patients with a history of severe allergic reactions to vitamin K products should avoid its use, and clinicians should assess suitability for each patient.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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