Product image of Kanavit (Phytomenadione) supplied by GNH India

Kanavit

Active Ingredient:
Phytomenadione
Origin:
EU

Kanavit (Phytomenadione)

Phytomenadione, the active ingredient in Kanavit, is a Vitamin K presented as an oral formulation for oral use. It is employed to correct vitamin K deficiency, manage bleeding episodes, and reverse the effects of vitamin K antagonist anticoagulants in patients requiring rapid coagulation restoration.

GNH India supplies Kanavit as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres and pharmacies worldwide.

Manufacturer / TM Owner

Zentiva, A.S.

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Indications & Clinical Uses

Kanavit is a vitamin K agent used to address disorders of coagulation and to counteract anticoagulant therapy.

  • Vitamin K deficiency: restores normal clotting factors in patients with low vitamin K levels.
  • Hemorrhage prevention and treatment: supports hemostasis in acute bleeding situations.
  • Warfarin reversal: rapidly re‑establishes coagulation in individuals receiving vitamin K antagonist anticoagulants.

How It Works

  • Phytomenadione acts as a cofactor for the enzyme gamma‑glutamyl carboxylase, enabling the carboxylation of clotting factors II, VII, IX and X. This post‑translational modification converts the factors into their active forms, thereby restoring the physiological cascade of blood coagulation and correcting bleeding tendencies.

Side Effects

Adverse reactions may occur with oral vitamin K therapy.

Common Side Effects

  • Nausea: mild gastrointestinal discomfort.
  • Diarrhea: loose stools occurring shortly after ingestion.
  • Headache: transient cranial pain.
  • Skin rash: mild erythematous eruption.
  • Elevated liver enzymes: mild, reversible increase.

Serious or Rare Side Effects

  • Anaphylaxis: severe allergic reaction requiring immediate medical attention.
  • Hemolytic anemia: rare destruction of red blood cells.
  • Thromboembolic events: unexpected clot formation.
  • Hyperbilirubinemia: elevated bilirubin levels in susceptible individuals.
  • Severe hypersensitivity: swelling of face, lips, or throat.

Precautions & Warnings

When prescribing Kanavit, clinicians should consider several safety measures.

  • Dose adjustment in liver disease: impaired metabolism may require lower doses.
  • Monitor INR in patients on anticoagulants: ensure therapeutic coagulation levels.
  • Avoid in known hypersensitivity: discontinue if allergic reactions develop.
  • Use with caution in newborns: vitamin K status is critical in this population.
  • Store at room temperature: keep in the original pack, protect from moisture.

Avoid Interactions

Kanavit can interact with several medications that affect coagulation or vitamin K metabolism.

Major Interactions (Avoid)

  • Warfarin: may reduce anticoagulant effect, leading to sub‑therapeutic INR.
  • Broad‑spectrum antibiotics (e.g., ampicillin‑clavulanate): can diminish intestinal vitamin K synthesis.

Moderate Interactions (Monitor Closely)

  • Cefoperazone or ceftriaxone: may alter vitamin K levels and affect clotting.
  • Barbiturates: increase hepatic metabolism of vitamin K.
  • Oral contraceptives: may enhance clotting tendency, requiring monitoring.

Frequently Asked Questions

Kanavit contains phytomenadione, a form of vitamin K, and is used to treat vitamin K deficiency, control bleeding, and reverse the anticoagulant effects of vitamin K antagonists such as warfarin. It helps restore normal clotting function in patients who need rapid hemostasis.

Phytomenadione serves as a cofactor for gamma‑glutamyl carboxylase, an enzyme that adds a carboxyl group to clotting factors II, VII, IX and X. This modification activates the factors, allowing the blood‑clotting cascade to proceed and correcting bleeding tendencies.

The appropriate dose of Kanavit is determined by the prescribing healthcare professional based on the patient’s clinical condition, age, weight and laboratory values. Dosage regimens are individualized and should follow the prescriber’s instructions.

Safety data for phytomenadione in pregnancy and lactation are limited. It should only be used if the potential benefit justifies any possible risk to the fetus or infant, and the decision must be made by a qualified healthcare provider.

To request Kanavit, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Kanavit provides phytomenadione in an oral form, similar to other vitamin K1 preparations. Compared with injectable vitamin K, oral Kanavit offers convenient administration but may have slower onset of action. Choice of product depends on clinical urgency, patient preference and the treating physician’s assessment.

Kanavit should be stored at room temperature, below 25 °C, in its original packaging to protect it from moisture and light. Keep the product out of reach of children and avoid storing it in humid or excessively hot environments.

Kanavit is taken orally, usually with water. The exact method of administration—such as with or without food—should follow the prescribing clinician’s guidance to ensure optimal absorption and effectiveness.

Serious risks include rare allergic reactions such as anaphylaxis, hemolytic anemia, and unexpected thromboembolic events. Patients should be monitored for signs of severe hypersensitivity, sudden clot formation or unexplained hemolysis, and medical attention should be sought immediately if these occur.

Kanavit should be avoided in individuals with known hypersensitivity to phytomenadione or any excipients in the formulation. Caution is also advised for patients with severe liver disease, newborns, or those receiving concurrent medications that significantly affect vitamin K metabolism.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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