Product image of Kandesartancileksetil/Amlodipin/Hidroklorotiazid Adamed (Amlodipine, Hydrochlorothiazide, Candesartan Cilexetil) supplied by GNH India

Kandesartancileksetil/Amlodipin/Hidroklorotiazid Adamed

Active Ingredient:
Amlodipine, Hydrochlorothiazide, Candesartan Cilexetil
Origin:
EU

Kandesartancileksetil/Amlodipin/Hidroklorotiazid Adamed (Amlodipine, Hydrochlorothiazide, Candesartan Cilexetil)

Candesartan cilexetil, amlodipine, and hydrochlorothiazide, the active ingredients in Kandesartancileksetil/Amlodipin/Hidroklorotiazid Adamed, are an angiotensin II receptor blocker, a calcium channel blocker, and a thiazide diuretic presented as oral tablets for oral use. They are prescribed to lower elevated blood pressure in adult patients with hypertension.
GNH India supplies Kandesartancileksetil/Amlodipin/Hidroklorotiazid Adamed as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Adamed Pharma S.A.

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Indications & Clinical Uses

  • Kandesartancileksetil/Amlodipin/Hidroklorotiazid Adamed is used to manage hypertension, a condition characterized by elevated arterial pressure.
  • Hypertension: reduces systolic and diastolic blood pressure and lowers the risk of cardiovascular events.
  • Isolated systolic hypertension: improves pulse pressure control in older adults.
  • Essential hypertension: provides a convenient fixed‑dose option for patients requiring multiple antihypertensive mechanisms.

How It Works

  • Candesartan cilexetil blocks angiotensin II type 1 receptors, preventing vasoconstriction and aldosterone release; amlodipine inhibits calcium influx into vascular smooth‑muscle cells, causing arterial dilation; and hydrochlorothiazide reduces sodium and water reabsorption in the distal convoluted tubule, decreasing plasma volume. The combined actions produce additive vasodilation and natriuresis, leading to sustained blood‑pressure reduction.

Side Effects

Common Side Effects

  • Dizziness or light‑headedness, especially after the first dose.
  • Headache or mild flushing.
  • Peripheral edema, particularly of the ankles.
  • Increased urination or mild electrolyte changes.
  • Fatigue or mild muscle cramps.
  • Dry mouth or mild gastrointestinal discomfort.

Serious or Rare Side Effects

  • Severe hypotension or syncope.
  • Acute kidney injury or marked rise in serum creatinine.
  • Hyperkalemia or severe electrolyte imbalance.
  • Angioedema involving face, lips, tongue, or airway.
  • Pancreatitis or severe abdominal pain.
  • Hepatic dysfunction or jaundice.

Precautions & Warnings

  • Before initiating therapy, patients should be evaluated for renal function, electrolyte status, and potential drug allergies.
  • Monitor blood pressure regularly: adjust dose if target not achieved.
  • Assess renal function: check serum creatinine and eGFR at baseline and periodically.
  • Check electrolytes: especially potassium and sodium levels.
  • Use caution in hepatic impairment: dose may need adjustment.
  • Avoid in patients with known hypersensitivity to any component.
  • Store at below 25°C: keep in the original pack, protect from moisture.

Avoid Interactions

When combined with certain medicines, the risk of adverse events may increase.

Major Interactions (Avoid)

  • Concomitant ACE inhibitors or other ARBs: risk of hyperkalemia and renal failure.
  • Potassium‑sparing diuretics or supplements: may cause dangerous hyperkalemia.
  • NSAIDs (e.g., ibuprofen, naproxen): can blunt antihypertensive effect and impair renal function.
  • Cyclosporine or tacrolimus: may increase serum creatinine.
  • Lithium: risk of lithium toxicity due to reduced clearance.

Moderate Interactions (Monitor Closely)

  • Strong CYP3A4 inhibitors (e.g., erythromycin, clarithromycin): may raise amlodipine levels.
  • CYP3A4 inducers (e.g., rifampicin, carbamazepine): may lower amlodipine exposure.
  • Other antihypertensives (beta‑blockers, ACE inhibitors): additive blood‑pressure lowering effect.
  • Antidiabetic agents: blood‑glucose control may improve, requiring dose adjustment.
  • Anticoagulants (warfarin): monitor INR as blood‑pressure changes can affect anticoagulation stability.

Frequently Asked Questions

Kandesartancileksetil/Amlodipin/Hidroklorotiazid Adamed is a fixed‑dose combination tablet that treats hypertension. By combining an angiotensin II receptor blocker, a calcium‑channel blocker, and a thiazide diuretic, it helps lower both systolic and diastolic blood pressure in adult patients who need multiple mechanisms to achieve control.

Candesartan blocks angiotensin II type 1 receptors, preventing vasoconstriction and aldosterone release. Amlodipine inhibits calcium entry into vascular smooth‑muscle cells, causing arterial dilation. Hydrochlorothiazide reduces sodium and water reabsorption in the distal tubule, decreasing plasma volume. Together, these actions produce additive vasodilation and natriuresis, resulting in sustained blood‑pressure reduction.

The specific dose of Kandesartancileksetil/Amlodipin/Hidroklorotiazid Adamed is determined by the prescribing clinician based on the patient’s blood‑pressure profile, renal function, and other individual factors. Only a qualified health‑care professional should set the dosage and adjust it as needed.

Safety in pregnancy and lactation has not been fully established for this combination. Candesartan and hydrochlorothiazide are generally contraindicated in pregnancy, and amlodipine should be used only if the potential benefit justifies the risk. Women who are pregnant, planning pregnancy, or breastfeeding should discuss alternatives with their health‑care provider.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies, and procurement teams worldwide. After verification of trade or institutional credentials, the sales team will respond with pricing, availability, shipping details (including any cold‑chain requirements), and required import documentation.

Compared with single‑agent therapy, the triple combination offers broader blood‑pressure control by targeting three pathways simultaneously, often reducing the number of pills a patient must take. It can be more convenient than prescribing separate agents and may improve adherence, but it also carries the combined safety profile of all three components.

Store the tablets at below 25 °C in a dry place. Keep them in the original container to protect from moisture and light. Do not store in bathrooms or near heat sources, and keep out of reach of children.

Kandesartancileksetil/Amlodipin/Hidroklorotiazid Adamed is taken orally, usually once daily in the morning, with or without food. Swallow the tablet whole with a full glass of water. Follow the prescribing clinician’s instructions regarding timing and any necessary dose adjustments.

Serious risks include severe hypotension, acute kidney injury, hyperkalemia, angioedema, and rare cases of pancreatitis or hepatic dysfunction. Patients should be educated to seek immediate medical attention if they experience swelling of the face or throat, sudden dizziness, marked decrease in urine output, or unexplained abdominal pain.

The combination should be avoided in patients with known hypersensitivity to any of its components, severe renal or hepatic impairment, uncontrolled hyperkalemia, or a history of angioedema related to ARBs. It is also contraindicated in pregnancy and should be used with caution in lactating women.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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