Product image of Kandoset (Amlodipine, Candesartan Cilexetil) supplied by GNH India

Kandoset

Active Ingredient:
Amlodipine, Candesartan Cilexetil
Origin:
EU

Kandoset (Amlodipine, Candesartan Cilexetil)

Amlodipine and Candesartan cilexetil, the active ingredients in Kandoset, are a calcium channel blocker and an angiotensin II receptor blocker presented as an oral tablet for systemic use. They work together to reduce peripheral vascular resistance and block angiotensin‑II mediated vasoconstriction, thereby lowering elevated blood pressure in adult patients diagnosed with hypertension.

GNH India supplies Kandoset as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, ensuring quality and regulatory conformity across markets with reliable logistics and comprehensive documentation support.

Manufacturer / TM Owner

Krka, D.D., Novo Mesto

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Indications & Clinical Uses

Kandoset is used in the management of hypertension, a condition affecting the arterial pressure regulation system.

  • Hypertension (essential): lowers systolic and diastolic blood pressure in adults.
  • High blood pressure: helps achieve target blood pressure levels as part of therapy.
  • Cardiovascular risk reduction: contributes to decreased risk of stroke and heart attack by controlling blood pressure.

How It Works

  • Amlodipine blocks L-type calcium channels in vascular smooth muscle, causing vasodilation and reduced peripheral resistance. Candesartan cilexetil is an oral pro‑drug that converts to candesartan, an antagonist of angiotensin II type 1 (AT1) receptors, preventing vasoconstriction and aldosterone release. The combined effect produces additive blood pressure reduction through complementary pathways.

Side Effects

Kandoset may cause a range of adverse reactions, most of which are mild and reversible.

Common Side Effects

  • Headache: mild to moderate intensity.
  • Peripheral edema: swelling of the ankles or lower legs.
  • Dizziness or light‑headedness, especially after standing.
  • Flushing: transient warmth and redness of the skin.
  • Fatigue: feeling unusually tired.
  • Palpitations: awareness of heartbeat.

Serious or Rare Side Effects

  • Angioedema: swelling of face, lips, tongue, or throat.
  • Severe hypotension: marked drop in blood pressure causing fainting.
  • Hepatic dysfunction: abnormal liver enzymes or hepatitis.
  • Renal impairment: worsening kidney function.
  • Myocardial infarction: rare occurrence of heart attack.
  • Allergic reactions: rash, itching, or anaphylaxis.

Precautions & Warnings

Before prescribing Kandoset, clinicians should consider several safety aspects.

  • Monitor blood pressure: ensure adequate control without excessive lowering.
  • Assess renal function: adjust therapy in patients with impaired kidneys.
  • Evaluate hepatic status: use caution in moderate to severe liver disease.
  • Pregnancy and lactation: avoid use unless benefits outweigh potential risks.
  • Review concomitant potassium‑sparing agents: risk of hyperkalaemia.
  • Store at room temperature: keep in the original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Kandoset can interact with other medicines, requiring careful management.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin): may increase amlodipine levels.
  • Dual renin‑angiotensin system blockade (e.g., ACE inhibitors, other ARBs): risk of renal dysfunction and hyperkalaemia.
  • Potassium‑sparing diuretics (e.g., spironolactone): heightened risk of hyperkalaemia.

Moderate Interactions (Monitor Closely)

  • NSAIDs: may blunt antihypertensive effect.
  • Other antihypertensives: additive blood pressure lowering.
  • CYP3A4 inducers (e.g., rifampicin): may reduce amlodipine exposure.
  • Lithium: increased lithium levels.
  • Diuretics: may affect electrolyte balance.

Frequently Asked Questions

Kandoset is prescribed to treat hypertension, helping to lower elevated systolic and diastolic blood pressure in adult patients. It combines two mechanisms—calcium channel blockade and angiotensin II receptor antagonism—to provide an additive antihypertensive effect.

Amlodipine relaxes vascular smooth muscle by blocking L‑type calcium channels, reducing peripheral resistance. Candesartan, released from its pro‑drug form, blocks AT1 receptors, preventing angiotensin II‑mediated vasoconstriction and aldosterone release. Together they produce a complementary reduction in blood pressure.

The appropriate dose of Kandoset is determined by the prescribing clinician based on the patient’s blood pressure, response to therapy, and individual health factors. Dosage adjustments are made according to clinical guidelines and patient monitoring.

Safety of Kandoset in pregnancy and lactation has not been established. It should be avoided unless the potential benefit justifies the potential risk to the fetus or infant, and the decision should be made by a qualified healthcare professional.

To order Kandoset, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any required import documentation.

Kandoset offers a fixed‑dose combination of a calcium channel blocker and an angiotensin II receptor blocker, providing broader blood pressure control than monotherapy. Compared with single‑agent ACE inhibitors or beta‑blockers, it may achieve target pressures with fewer pills, improving adherence.

Kandoset tablets should be stored at room temperature, below 25 °C, in the original blister pack or container. Protect them from moisture, excessive heat and direct sunlight to maintain potency throughout the shelf life.

Kandoset is taken orally, usually once daily, with or without food. The tablet should be swallowed whole with a glass of water and not chewed or crushed, unless otherwise directed by a healthcare professional.

Serious risks include angioedema, severe hypotension, hepatic dysfunction, and renal impairment. Patients should be instructed to seek immediate medical attention if they experience swelling of the face or throat, sudden dizziness, jaundice, or a marked decrease in urine output.

Kandoset is contraindicated in patients with known hypersensitivity to amlodipine, candesartan, or any excipients, as well as in those with severe hepatic impairment. Caution is also advised for individuals with unstable heart failure, severe renal disease, or a history of angioedema.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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