Product image of Kanilad (Lacosamide) supplied by GNH India

Kanilad

Active Ingredient:
Lacosamide
Origin:
EU

Kanilad (Lacosamide)

Lacosamide, the active ingredient in Kanilad, is an anticonvulsant presented as an oral formulation for oral use. It is indicated for the treatment of partial‑onset seizures in patients with epilepsy.

GNH India supplies Kanilad as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Medochemie Ltd.

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Indications & Clinical Uses

  • Kanilad (lacosamide) is used within the antiepileptic drug class to manage focal seizure disorders.
  • Partial‑onset seizures: reduces seizure frequency when added to existing therapy.
  • Adjunctive therapy in focal epilepsy: improves overall seizure control as an add‑on medication.
  • Refractory focal seizures: offers an additional option for patients not responding to other antiepileptics.

How It Works

  • Lacosamide enhances the slow inactivation of voltage‑gated sodium channels, stabilizing neuronal membranes and limiting repetitive firing. It also binds to the collapsin response mediator protein‑2 (CRMP2), modulating neuronal excitability and contributing to its antiepileptic effect.

Side Effects

Lacosamide may cause a range of adverse reactions, from mild to serious.

Common Side Effects

  • Dizziness: sensation of light‑headedness or unsteadiness.
  • Nausea: mild to moderate stomach upset.
  • Headache: tension‑type or throbbing pain.
  • Fatigue: feeling unusually tired.
  • Visual disturbances: blurred vision or double vision.

Serious or Rare Side Effects

  • Cardiac arrhythmia: PR‑interval prolongation.
  • Severe skin reactions: Stevens‑Johnson syndrome or toxic epidermal necrolysis.
  • Suicidal ideation: thoughts of self‑harm.
  • Hepatic dysfunction: elevated liver enzymes.
  • Respiratory depression: difficulty breathing in severe cases.

Precautions & Warnings

  • When prescribing or dispensing Kanilad, consider the following safety measures.
  • Renal impairment: adjust therapy based on renal function.
  • Cardiac monitoring: assess ECG for PR‑interval changes.
  • Pregnancy: use only if benefits outweigh potential risks.
  • Concomitant CNS depressants: monitor for enhanced sedation.
  • Alcohol use: advise patients to limit intake.
  • Store at ambient temperature: keep below 25°C in original packaging, protect from moisture.

Avoid Interactions

Lacosamide can interact with several medicines, requiring careful management.

Major Interactions (Avoid)

  • Strong CYP3A4 inducers (e.g., carbamazepine, phenytoin): may reduce lacosamide levels.
  • Class III antiarrhythmics (e.g., amiodarone): increase risk of cardiac conduction abnormalities.

Moderate Interactions (Monitor Closely)

  • Other antiepileptics (e.g., valproate, levetiracetam): may affect seizure control.
  • CNS depressants (e.g., benzodiazepines, opioids): monitor for additive sedation.
  • Alcohol: may enhance dizziness and drowsiness.

Frequently Asked Questions

Kanilad contains lacosamide, an antiepileptic drug indicated for the treatment of partial‑onset (focal) seizures in patients with epilepsy, typically as an add‑on therapy to improve seizure control.

Lacosamide enhances the slow inactivation of voltage‑gated sodium channels, stabilizing neuronal membranes and reducing repetitive firing. It also binds to CRMP2, influencing neuronal excitability, which together help prevent seizure activity.

The dosage of Kanilad is individualized. A qualified prescriber determines the appropriate dose based on the patient’s clinical condition, response to therapy, and any relevant medical factors.

Safety data for lacosamide in pregnancy and lactation are limited. It should only be used if the potential benefit justifies any possible risk to the fetus or infant, and decisions should be made in consultation with a healthcare professional.

To order Kanilad, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Kanilad (lacosamide) offers a distinct mechanism by enhancing slow sodium‑channel inactivation, which differs from many traditional antiepileptics that target fast inactivation. This can provide an alternative for patients who have inadequate response or intolerable side effects with other agents.

Kanilad should be stored at ambient temperature, below 25 °C, in its original packaging. Keep the product away from moisture and direct sunlight to maintain stability.

Kanilad is taken orally, usually as a tablet, and should be swallowed whole with water. The exact administration schedule is set by the prescribing clinician.

Serious risks include cardiac conduction abnormalities such as PR‑interval prolongation, severe skin reactions like Stevens‑Johnson syndrome, and rare cases of suicidal thoughts. Patients should be monitored for these events, especially during treatment initiation.

Kanilad is contraindicated in patients with known hypersensitivity to lacosamide or any of its excipients, and it should be used with caution in individuals with significant cardiac conduction disorders or severe renal impairment.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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