Product image of Kanilad (Lacosamide) supplied by GNH India

Kanilad

Active Ingredient:
Lacosamide
Origin:
EU

Kanilad (Lacosamide)

Lacosamide, the active ingredient in Kanilad, is a sodium channel blocker presented as an oral tablet for oral use. It is indicated for the treatment of partial‑onset seizures in patients with epilepsy.
GNH India supplies Kanilad as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Medochemie Ltd.

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Indications & Clinical Uses

Lacosamide is used to manage seizure disorders that involve focal neuronal hyper‑excitability.

  • Partial‑onset seizures: reduces seizure frequency when used as adjunctive therapy.
  • Focal seizures: helps achieve better seizure control in combination with other antiepileptics.
  • Refractory focal epilepsy: provides an additional option for patients not responding adequately to first‑line agents.

How It Works

  • Lacosamide enhances the slow inactivation of voltage‑gated sodium channels, which stabilizes hyperexcitable neuronal membranes and diminishes repetitive neuronal firing. By selectively targeting the slow inactivation phase, it reduces the propagation of epileptiform activity without markedly affecting normal neuronal conduction.

Side Effects

Lacosamide may cause a range of adverse reactions, from mild to severe.

Common Side Effects

  • Dizziness: sensation of light‑headedness or unsteadiness.
  • Fatigue: increased tiredness or lack of energy.
  • Nausea: feeling of stomach upset or urge to vomit.
  • Headache: mild to moderate cranial pain.
  • Blurred vision: temporary visual disturbances.
  • Diplopia: double vision.

Serious or Rare Side Effects

  • Suicidal thoughts: emergence of depressive or suicidal ideation.
  • Severe skin reactions: such as Stevens‑Johnson syndrome or toxic epidermal necrolysis.
  • Cardiac arrhythmia: alterations in heart rhythm, including PR‑interval prolongation.
  • Respiratory depression: reduced breathing effort, especially with CNS depressants.
  • Allergic reactions: anaphylaxis or severe hypersensitivity.

Precautions & Warnings

Before initiating therapy, consider patient‑specific factors and safety measures.

  • Renal impairment: adjust dosing or monitor renal function closely.
  • Hepatic impairment: evaluate liver function and consider dose modification.
  • Cardiac conduction disorders: avoid in patients with known PR‑interval prolongation.
  • Concomitant CNS depressants: monitor for additive sedation or respiratory effects.
  • Pregnancy considerations: use only if potential benefit justifies potential risk.
  • Store at ambient temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Lacosamide can interact with several medicines, requiring attention to avoid reduced efficacy or increased toxicity.

Major Interactions (Avoid)

  • Strong CYP3A4 inducers (e.g., carbamazepine, phenytoin, rifampin): may markedly lower lacosamide levels.

Moderate Interactions (Monitor Closely)

  • CYP3A4 inhibitors (e.g., ketoconazole, erythromycin): may increase lacosamide exposure.
  • Other antiepileptics (e.g., valproate): may require dose adjustments.
  • Alcohol: can enhance central nervous system depression.
  • Drugs that prolong PR interval (e.g., digoxin): monitor cardiac conduction.

Frequently Asked Questions

Kanilad contains the active ingredient lacosamide and is prescribed for the treatment of partial‑onset seizures in patients with epilepsy. It is used as an adjunctive therapy to help reduce the frequency of focal seizures when combined with other antiepileptic medications.

Lacosamide enhances the slow inactivation of voltage‑gated sodium channels in neuronal membranes. This stabilizes hyperexcitable neurons, limits repetitive firing, and thereby reduces the spread of epileptic activity without significantly affecting normal neuronal signaling.

The appropriate dose of Kanilad is determined by the prescribing healthcare professional based on the individual’s clinical condition, age, renal and hepatic function, and response to therapy. Patients should follow the dosage instructions provided by their prescriber.

Safety data for lacosamide in pregnancy and lactation are limited. It should only be used if the potential benefit to the mother outweighs any possible risk to the fetus or infant. Women who are pregnant, planning pregnancy, or breastfeeding should discuss risks with their healthcare provider.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity of Kanilad. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Kanilad (lacosamide) belongs to the sodium channel blocker class, offering a distinct mechanism that enhances slow inactivation of sodium channels. Compared with other agents such as carbamazepine or levetiracetam, lacosamide may have a different side‑effect profile and drug‑interaction potential, making it a useful alternative for patients who need additional seizure control.

Kanilad should be stored at ambient temperature, below 25 °C, in its original packaging to protect it from moisture and light. Keep the product out of reach of children and avoid storing in humid or excessively hot environments.

Kanilad is administered orally, typically as a tablet taken with or without food. The exact dosing schedule and whether it is taken once or twice daily are determined by the prescriber based on the patient’s therapeutic needs.

Serious risks include the potential for suicidal thoughts or behavior, severe skin reactions such as Stevens‑Johnson syndrome, cardiac conduction abnormalities like PR‑interval prolongation, and rare cases of respiratory depression, especially when combined with other central nervous system depressants.

Kanilad is contraindicated in patients with known hypersensitivity to lacosamide or any of its excipients, and it should be used with caution in individuals with significant cardiac conduction disorders, severe renal or hepatic impairment, or those taking medications that may cause dangerous interactions.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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