Product image of Kanilad (Lacosamide) supplied by GNH India

Kanilad

Active Ingredient:
Lacosamide
Origin:
EU

Kanilad (Lacosamide)

Lacosamide, the active ingredient in Kanilad, is an anticonvulsant presented as an oral tablet for oral use. It is used as adjunctive therapy for partial‑onset seizures in epilepsy.

GNH India supplies Kanilad as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Medochemie Hellas Sa

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Indications & Clinical Uses

  • Lacosamide is an antiepileptic drug indicated for focal seizure disorders.
  • Partial‑onset seizures: adjunctive therapy to reduce seizure frequency in patients with epilepsy.
  • Focal epilepsy: improves seizure control when added to existing antiepileptic regimens.

How It Works

  • Lacosamide enhances the slow inactivation of voltage‑gated sodium channels, which stabilizes hyper‑excitable neuronal membranes and reduces repetitive neuronal firing. By selectively targeting this channel state, it diminishes the propagation of epileptic discharges without significantly affecting normal neuronal activity.

Side Effects

Lacosamide may cause a range of adverse reactions, from mild to serious.

Common Side Effects

  • Dizziness: sensation of light‑headedness or unsteadiness.
  • Nausea: feeling of stomach upset or urge to vomit.
  • Headache: mild to moderate pain in the head region.
  • Fatigue: unusual tiredness or lack of energy.
  • Blurred vision: temporary visual disturbances.
  • Diplopia: double vision.

Serious or Rare Side Effects

  • Suicidal ideation: thoughts of self‑harm requiring immediate evaluation.
  • Cardiac conduction abnormalities: PR‑interval prolongation that may lead to arrhythmia.
  • Severe skin reactions: Stevens‑Johnson syndrome or toxic epidermal necrolysis.
  • Hypersensitivity: rash, swelling, or anaphylaxis.
  • Hepatic enzyme elevation: significant increase in liver function tests.
  • Respiratory depression: marked reduction in breathing effort.

Precautions & Warnings

  • Before initiating therapy, consider the following safety measures.
  • Renal impairment: assess kidney function and monitor for accumulation.
  • Cardiac conduction disorders: obtain baseline ECG and monitor PR interval.
  • Pregnancy: risk unknown; use only if potential benefit justifies the risk.
  • Concomitant antiepileptic drugs: observe for changes in seizure control.
  • Avoid abrupt discontinuation: taper gradually to prevent seizure exacerbation.
  • Store at room temperature: keep in the original packaging, protect from moisture and heat.

Avoid Interactions

Lacosamide can interact with several medications; awareness of the interaction level is essential.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., ketoconazole): may increase lacosamide plasma concentrations.
  • Drugs that prolong PR interval (e.g., class IA antiarrhythmics): risk of additive cardiac conduction delay.
  • Other sodium‑channel blockers (e.g., carbamazepine): heightened risk of central nervous system depression.

Moderate Interactions (Monitor Closely)

  • Additional antiepileptic drugs: may alter overall seizure control efficacy.
  • Alcohol: can intensify dizziness and sedation.
  • CYP2C19 substrates: potential alteration of their plasma levels.

Frequently Asked Questions

Kanilad contains the active ingredient lacosamide and is prescribed as an adjunctive treatment for partial‑onset (focal) seizures in patients with epilepsy. It is added to existing antiepileptic regimens to help reduce the frequency of seizure episodes.

Lacosamide enhances the slow inactivation of voltage‑gated sodium channels in neuronal membranes. This action stabilizes hyper‑excitable neurons, limiting the repetitive firing that underlies seizure activity, while preserving normal neuronal function.

The dosage of Kanilad is individualized by the prescribing clinician based on the patient’s clinical condition, response, and tolerability. The prescriber determines the appropriate strength, titration schedule, and maintenance dose.

Safety data for lacosamide in pregnancy and lactation are limited. It should be used only if the potential benefit justifies any potential risk to the fetus or infant, and the decision should be made in consultation with a healthcare professional.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Compared with many traditional antiepileptics, lacosamide’s unique mechanism—enhancing slow sodium‑channel inactivation—offers a different therapeutic profile. It may be preferred when patients need additional seizure control without the enzyme‑inducing effects seen with some older agents.

Kanilad should be stored at room temperature, below 25 °C, in its original packaging. Keep the product away from moisture and direct sunlight to maintain stability and potency.

Kanilad is taken orally, usually as a tablet, and should be swallowed whole with water. It can be taken with or without food, but consistency with regard to meals helps maintain steady drug levels.

Serious risks include the potential for suicidal thoughts, cardiac conduction abnormalities such as PR‑interval prolongation, severe skin reactions like Stevens‑Johnson syndrome, and significant liver enzyme elevations. Prompt medical attention is required if any of these occur.

Kanilad is contraindicated in patients with known hypersensitivity to lacosamide or any of its excipients. Caution is also advised for individuals with severe cardiac conduction disorders, uncontrolled arrhythmias, or those taking medications that markedly prolong the PR interval.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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