Product image of Kanilad (Lacosamide) supplied by GNH India

Kanilad

Active Ingredient:
Lacosamide
Origin:
EU

Kanilad (Lacosamide)

Lacosamide, the active ingredient in Kanilad, is an anticonvulsant presented as an oral tablet for oral use. It treats partial‑onset seizures in patients with epilepsy.\n\nGNH India supplies Kanilad as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Medochemie Ltd.

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Indications & Clinical Uses

  • Lacosamide is indicated for the treatment of focal seizure disorders within the broader epilepsy disease category.\n\n- Partial‑onset seizures: Reduces seizure frequency as adjunctive therapy in patients with epilepsy.\n- Focal epilepsy: Provides seizure control when added to existing antiepileptic regimens.\n- Refractory epilepsy: Improves seizure management in patients not adequately controlled by other drugs.

How It Works

  • Lacosamide enhances the slow inactivation of voltage‑gated sodium channels, stabilizing hyper‑excitable neuronal membranes. It also binds to collapsin response mediator protein‑2 (CRMP‑2), modulating neuronal differentiation and axonal outgrowth, which together contribute to its antiepileptic effect.

Side Effects

  • Lacosamide may cause a range of adverse reactions, which are generally categorized by frequency and severity.\n\nCommon Side Effects:\n- Dizziness\n- Headache\n- Nausea\n- Fatigue\n- Blurred vision\n\nSerious or Rare Side Effects:\n- Cardiac conduction abnormalities (e.g., PR‑interval prolongation)\n- Suicidal ideation or behavior\n- Severe skin reactions such as Stevens‑Johnson syndrome\n- Hypersensitivity reactions including anaphylaxis\n- Elevated liver enzymes

Precautions & Warnings

  • When prescribing Lacosamide, clinicians should consider several safety and handling points.\n\n- Renal impairment: Adjust dose based on renal function.\n- Hepatic impairment: Monitor liver function tests regularly.\n- Cardiac conduction disorders: Obtain baseline ECG and monitor for PR‑interval changes.\n- Pregnancy: Use only if potential benefit justifies the unknown risk to the fetus.\n- Concomitant CNS depressants: Observe for additive sedation or respiratory depression.\n- Store at ambient temperature: Keep below 25 °C, protect from moisture and light.

Avoid Interactions

  • Lacosamide can interact with other medicines, affecting its efficacy or safety.\n\nMajor Interactions (Avoid):\n- Strong CYP3A4 inhibitors (e.g., ketoconazole): May increase Lacosamide plasma levels.\n- Class III antiarrhythmics (e.g., amiodarone): Heightened risk of cardiac conduction disturbances.\n- Other sodium‑channel blockers (e.g., carbamazepine): Potential for additive toxicity.\n\nModerate Interactions (Monitor Closely):\n- Co‑administration with other antiepileptic drugs: May require dose adjustments.\n- Alcohol or CNS depressants: Increased sedation or dizziness.\n- Hormonal contraceptives: Possible reduction in contraceptive efficacy.

Frequently Asked Questions

Kanilad contains the active ingredient Lacosamide and is used as an adjunctive therapy for partial‑onset (focal) seizures in patients with epilepsy. It helps reduce the frequency of seizures when added to existing antiepileptic regimens.

Lacosamide enhances the slow inactivation of voltage‑gated sodium channels, which stabilizes neuronal membranes and reduces hyper‑excitability. It also binds to CRMP‑2, influencing neuronal differentiation and axonal growth, contributing to its seizure‑controlling properties.

The specific dose of Kanilad is individualized. A qualified prescriber determines the appropriate starting dose and titration schedule based on the patient’s clinical condition, age, renal and hepatic function, and response to therapy.

Lacosamide’s pregnancy category is listed as unknown. Use during pregnancy or lactation only if the potential therapeutic benefit justifies any potential risk to the fetus or infant. Clinicians should discuss risks and benefits with the patient.

To request Kanilad, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Compared with older sodium‑channel blockers such as carbamazepine, Lacosamide offers a distinct mechanism by enhancing slow inactivation rather than fast inactivation. This can result in a different side‑effect profile and may be better tolerated in patients who experience adverse effects with traditional agents.

Kanilad should be stored at ambient temperature, preferably below 25 °C. Keep the tablets in the original container, protect them from moisture and direct light, and ensure the packaging remains tightly closed until use.

Kanilad is taken orally, usually with or without food, as directed by the prescribing physician. Tablets should be swallowed whole with a glass of water and not crushed or chewed unless specifically instructed.

Serious risks include cardiac conduction abnormalities such as PR‑interval prolongation, suicidal thoughts or behaviors, severe skin reactions like Stevens‑Johnson syndrome, hypersensitivity reactions including anaphylaxis, and significant liver enzyme elevations. Patients should be monitored for these events.

Kanilad is contraindicated in patients with known hypersensitivity to Lacosamide or any of its excipients. Caution is advised for individuals with pre‑existing cardiac conduction disorders, severe hepatic impairment, or those taking medications that may cause dangerous interactions.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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