Product image of Kanilad Os (Lacosamide) supplied by GNH India

Kanilad Os

Active Ingredient:
Lacosamide
Origin:
EU

Kanilad Os (Lacosamide)

Lacosamide, the active ingredient in Kanilad Os, is a sodium channel blocker presented as an oral tablet for oral use. It is indicated for the treatment of partial‑onset seizures in patients with epilepsy.

GNH India supplies Kanilad Os as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Medochemie Hellas Sa

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Indications & Clinical Uses

Lacosamide is an antiepileptic drug that acts on neuronal sodium channels to control seizure activity.

  • Partial‑onset seizures: reduces the frequency and severity of focal seizures.
  • Epilepsy: provides adjunctive therapy for patients with focal epilepsy.
  • Refractory focal epilepsy: improves seizure control when other treatments are insufficient.

How It Works

  • Lacosamide enhances the slow inactivation of voltage‑gated sodium channels in neuronal membranes, stabilizing hyper‑excitable neuronal membranes and decreasing repetitive neuronal firing, which helps to control seizure activity in epilepsy.

Side Effects

Lacosamide may cause a range of adverse reactions, varying from mild to serious.

Common Side Effects

  • Dizziness: sensation of light‑headedness or unsteadiness.
  • Nausea: feeling of stomach upset or urge to vomit.
  • Fatigue: unusual tiredness or lack of energy.
  • Headache: mild to moderate pain in the head.

Serious or Rare Side Effects

  • Stevens‑Johnson syndrome: severe skin reaction requiring immediate medical attention.
  • Cardiac arrhythmia: abnormal heart rhythm that may be life‑threatening.
  • Suicidal ideation: thoughts of self‑harm that need urgent evaluation.
  • Severe skin reactions: including toxic epidermal necrolysis.
  • Hypersensitivity: allergic reactions such as rash, swelling, or breathing difficulty.

Precautions & Warnings

Before prescribing lacosamide, clinicians should consider several safety aspects.

  • Cardiac monitoring: assess ECG for PR‑interval prolongation.
  • Renal function: evaluate kidney performance, especially in patients with impairment.
  • Hepatic function: adjust use in patients with liver disease.
  • Discontinuation: avoid abrupt cessation to prevent seizure worsening.
  • Patient counseling: advise about dizziness and driving safety.
  • Store at room temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Lacosamide can interact with other medicines, requiring careful management.

Major Interactions (Avoid)

  • Carbamazepine: may reduce lacosamide plasma levels, decreasing efficacy.
  • Phenytoin: may increase risk of cardiac conduction abnormalities.

Moderate Interactions (Monitor Closely)

  • CYP2C19 inhibitors (e.g., fluconazole): may raise lacosamide concentrations.
  • Other antiepileptics (e.g., valproate): may enhance central nervous system side effects.
  • Concomitant QT‑prolonging drugs: monitor cardiac rhythm for additive effects.

Frequently Asked Questions

Kanilad Os contains lacosamide, an antiepileptic medication prescribed to control partial‑onset seizures in patients with epilepsy. It is used as adjunctive therapy to reduce seizure frequency and improve overall seizure management.

Lacosamide enhances the slow inactivation of voltage‑gated sodium channels in neurons, stabilizing hyper‑excitable membranes and decreasing repetitive firing. This mechanism helps to suppress the abnormal electrical activity that leads to seizures.

The appropriate dose of Kanilad Os is determined by the prescribing clinician based on the patient’s age, weight, renal and hepatic function, and response to therapy. Patients should follow the individualized dosing regimen provided by their healthcare professional.

Safety data for lacosamide in pregnancy and lactation are limited. Clinicians should weigh potential benefits against possible risks and consider alternative treatments when appropriate. Women who are pregnant, planning pregnancy, or breastfeeding should discuss options with their healthcare provider.

To request Kanilad Os, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Lacosamide differs from many antiepileptics by specifically enhancing slow inactivation of sodium channels, offering a distinct mechanism that can be effective when other drugs fail. It is generally well‑tolerated, but the choice of therapy depends on seizure type, patient comorbidities, and individual response.

Kanilad Os should be stored at room temperature, below 25 °C, in its original packaging to protect it from moisture and light. Keep the tablets out of reach of children and do not store in humid or excessively hot environments.

Kanilad Os is taken orally, usually with or without food, as directed by the prescribing physician. Tablets should be swallowed whole with water and not crushed or chewed unless specifically instructed by a healthcare professional.

Serious risks include severe skin reactions such as Stevens‑Johnson syndrome, cardiac conduction abnormalities like PR‑interval prolongation, and psychiatric effects such as suicidal thoughts. Patients should seek immediate medical attention if they experience rash, chest pain, palpitations, or mood changes.

Kanilad Os is contraindicated in patients with known hypersensitivity to lacosamide or any of its excipients. Caution is advised for individuals with significant cardiac conduction disorders, severe hepatic impairment, or those taking interacting medications that could increase toxicity.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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