Product image of Kantos Master Nexthaler (Formoterol Fumarate Dihydrate, Beclometasone Dipropionate Anhydrous) supplied by GNH India

Kantos Master Nexthaler

Active Ingredient:
Formoterol Fumarate Dihydrate, Beclometasone Dipropionate Anhydrous
Origin:
EU

Kantos Master Nexthaler (Formoterol Fumarate Dihydrate, Beclometasone Dipropionate Anhydrous)

Beclometasone dipropionate / Formoterol fumarate, the active ingredient in Kantos Master Nexthaler, is an inhaled corticosteroid/long‑acting β2‑agonist combination presented as a dry powder inhaler for inhalation use. It is indicated for maintenance treatment of asthma and chronic obstructive pulmonary disease in adult and adolescent patients.

GNH India supplies Kantos Master Nexthaler as a licensed, GDP‑compliant international pharmaceutical supplier, providing the product to hospitals, pharmacies and clinics worldwide from its EU‑originated manufacturing sources. The company ensures quality and regulatory compliance through rigorous quality assurance processes.

Manufacturer / TM Owner

Chiesi Farmaceutici S.P.A.

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Indications & Clinical Uses

Kantos Master Nexthaler, a combined inhaled corticosteroid and long‑acting β2‑agonist, is used in the management of obstructive airway diseases.

  • Asthma: reduces airway inflammation and provides bronchodilation for improved symptom control.
  • COPD: delivers maintenance bronchodilation and anti‑inflammatory effects to lessen exacerbations.
  • Severe persistent asthma: enhances lung function and decreases reliance on rescue inhalers.

How It Works

  • Beclometasone dipropionate binds to intracellular glucocorticoid receptors, modulating gene transcription to suppress inflammatory cytokines, eosinophil activity and mucus production in the airways. Formoterol fumarate selectively stimulates β2‑adrenergic receptors on bronchial smooth muscle, activating adenylate cyclase and increasing cyclic AMP, which relaxes the muscle and produces sustained bronchodilation. The combined action provides both anti‑inflammatory and long‑acting bronchodilator effects.

Side Effects

The inhaled combination may cause a range of adverse reactions, varying from mild to serious.

Common Side Effects

  • Oral thrush (candidiasis)
  • Hoarseness or voice change
  • Cough or throat irritation
  • Headache

Serious or Rare Side Effects

  • Paradoxical bronchospasm
  • Adrenal suppression
  • Severe allergic reaction (anaphylaxis)

Precautions & Warnings

When prescribing Kantos Master Nexthaler, consider the following precautions.

  • Assess infection risk: monitor for oral candidiasis and treat promptly.
  • Evaluate cardiovascular status: use cautiously in patients with arrhythmias or ischemic heart disease.
  • Avoid abrupt discontinuation: taper the dose if long‑term high‑dose therapy is required.
  • Limit concurrent inhaled steroids: monitor for systemic corticosteroid effects.
  • Pregnancy and lactation: consult a healthcare professional as safety data are limited.
  • Store at ambient temperature: keep in original container, protect from moisture and heat.

Avoid Interactions

Kantos Master Nexthaler may interact with other medicines; review the following.

Major Interactions (Avoid)

  • Beta‑blockers: may diminish bronchodilator response and precipitate bronchospasm.
  • MAO inhibitors: can increase risk of hypertensive episodes with LABA component.
  • Strong CYP3A4 inhibitors (e.g., ketoconazole): raise systemic corticosteroid exposure.

Moderate Interactions (Monitor Closely)

  • Diuretics: may exacerbate hypokalemia caused by β2‑agonist activity.
  • Theophylline: additive stimulant effects on the cardiovascular system.
  • Other inhaled corticosteroids: increase total glucocorticoid load, raising risk of systemic effects.

Frequently Asked Questions

Kantos Master Nexthaler is a prescription inhaler that combines an inhaled corticosteroid with a long‑acting β2‑agonist. It is indicated for the maintenance treatment of asthma and chronic obstructive pulmonary disease (COPD) in adults and adolescents, helping to control symptoms and reduce the frequency of exacerbations.

Beclometasone dipropionate activates glucocorticoid receptors in airway cells, suppressing inflammatory mediators and reducing swelling. Formoterol fumarate binds to β2‑adrenergic receptors on bronchial smooth muscle, increasing cyclic AMP and causing sustained relaxation of the airways. Together they provide anti‑inflammatory and bronchodilatory effects.

The prescribed dose of Kantos Master Nexthaler is determined by a healthcare professional based on the individual’s disease severity, age, and response to therapy. Typical regimens involve inhaling a specific number of doses twice daily, but the exact schedule should always follow the prescriber’s instructions.

Safety data for beclometasone dipropionate / formoterol fumarate in pregnancy and lactation are limited. The product should only be used if the potential benefit to the mother outweighs any possible risk to the fetus or infant. Pregnant or nursing patients should discuss use with their healthcare provider.

To order Kantos Master Nexthaler, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, confirming trade or institutional credentials before providing pricing, availability, shipping details and any necessary import documentation.

Kantos Master Nexthaler contains beclometasone dipropionate and formoterol fumarate, a combination similar in class to budesonide/formoterol or fluticasone/salmeterol. All provide anti‑inflammatory and bronchodilator actions, but differences exist in potency, onset of action, device design and regulatory approvals. Choice depends on clinical response, patient preference and formulary considerations.

Store Kantos Master Nexthaler at ambient temperature, below 25 °C, in its original packaging. Protect the device from moisture, direct sunlight and extreme heat. Keep the inhaler out of reach of children and do not expose it to freezing conditions.

The medication is delivered via a dry‑powder Nexthaler device. The patient should exhale fully away from the inhaler, place the mouthpiece in the mouth, seal lips, and inhale sharply and deeply. After inhalation, hold the breath for a few seconds before exhaling. The device should be primed according to the manufacturer’s instructions before first use.

Serious adverse reactions, although rare, include paradoxical bronchospasm, adrenal suppression leading to systemic corticosteroid effects, and severe allergic reactions such as anaphylaxis. Patients should seek immediate medical attention if they experience sudden worsening of breathing, signs of infection, or any symptoms of a severe allergic response.

Kantos Master Nexthaler is contraindicated in individuals with known hypersensitivity to beclometasone

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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