Product image of Kantos Nexthaler (Formoterol Fumarate Dihydrate, Beclometasone Dipropionate Anhydrous) supplied by GNH India

Kantos Nexthaler

Active Ingredient:
Formoterol Fumarate Dihydrate, Beclometasone Dipropionate Anhydrous
Origin:
EU

Kantos Nexthaler (Formoterol Fumarate Dihydrate, Beclometasone Dipropionate Anhydrous)

Beclometasone dipropionate / Formoterol fumarate, the active ingredient in Kantos Nexthaler, is an inhaled corticosteroid/long‑acting β2‑agonist combination presented as a dry powder inhaler for inhalation use. It treats asthma and chronic obstructive pulmonary disease as maintenance therapy in adults and children.

GNH India supplies Kantos Nexthaler as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Chiesi Gmbh

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Indications & Clinical Uses

  • Kantos Nexthaler combines an inhaled corticosteroid and a long‑acting β2‑agonist to provide maintenance control of obstructive airway diseases.
  • Asthma: improves long‑term symptom control and reduces exacerbations.
  • COPD: maintains airway patency, decreases breathlessness and lowers risk of flare‑ups.
  • Bronchial hyper‑responsiveness: reduces airway inflammation and reactivity.
  • Reversible airway obstruction: provides sustained bronchodilation and anti‑inflammatory effect.

How It Works

  • Beclometasone dipropionate binds intracellular glucocorticoid receptors, altering gene transcription to suppress inflammatory cytokines, reduce airway edema and mucus production. Formoterol fumarate activates β2‑adrenergic receptors on bronchial smooth muscle, increasing cyclic AMP levels, which relaxes the muscle and produces prolonged bronchodilation, together delivering anti‑inflammatory and bronchodilatory effects.

Side Effects

Common Side Effects

  • Throat irritation or hoarseness.
  • Cough after inhalation.
  • Oral candidiasis (thrush).
  • Headache.
  • Nasopharyngitis.

Serious or Rare Side Effects

  • Paradoxical bronchospasm.
  • Adrenal suppression with prolonged high‑dose use.
  • Severe allergic reaction such as anaphylaxis.
  • Cardiac arrhythmias or tachycardia.
  • Pneumonia, especially in COPD patients.

Precautions & Warnings

Before prescribing Kantos Nexthaler, clinicians should consider the following precautions.

  • Assess asthma or COPD control before initiating: ensure patient has an appropriate rescue inhaler.
  • Monitor for oral thrush: advise rinsing mouth after each dose.
  • Avoid abrupt discontinuation: may lead to worsening symptoms.
  • Use with caution in patients with cardiovascular disease: monitor heart rate and blood pressure.
  • Store at ambient temperature below 25°C: keep in original pack, protect from moisture.

Avoid Interactions

Kantos Nexthaler may interact with other medicines; awareness of interaction severity is important.

Major Interactions (Avoid)

  • Beta‑blockers: may diminish bronchodilator effect.
  • MAO inhibitors: potential for hypertensive crisis with formoterol.
  • Diuretics: may increase risk of hypokalemia.

Moderate Interactions (Monitor Closely)

  • Strong CYP3A4 inhibitors (e.g., ketoconazole): may raise systemic corticosteroid exposure.
  • Ritonavir: can increase formoterol plasma levels.
  • Theophylline: may enhance stimulant effects, requiring monitoring.

Frequently Asked Questions

Kantos Nexthaler is a prescription dry‑powder inhaler that combines beclometasone dipropionate and formoterol fumarate. It is indicated for the maintenance treatment of asthma and chronic obstructive pulmonary disease, helping to control airway inflammation and provide long‑lasting bronchodilation in adults and children.

Beclometasone dipropionate is a glucocorticoid that penetrates airway cells and binds to intracellular glucocorticoid receptors. This binding alters gene transcription, suppressing inflammatory cytokines, reducing airway edema, and decreasing mucus production, which together lower airway hyper‑responsiveness.

The dose of Kantos Nexthaler is individualized by the prescribing clinician based on the patient’s age, disease severity, and response to therapy. Patients should follow the specific inhalation instructions provided by their healthcare professional and not adjust the dose without medical advice.

Safety data for Kantos Nexthaler in pregnancy and lactation are limited. It should only be used if the potential benefit to the mother outweighs any potential risk to the fetus or infant, and the decision must be made by the prescriber in consultation with the patient.

To order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any required import documentation.

Unlike single‑component inhalers, Kantos Nexthaler delivers both an inhaled corticosteroid and a long‑acting β2‑agonist in one device. This dual action can improve adherence, simplify maintenance regimens, and provide combined anti‑inflammatory and bronchodilator benefits compared with using separate corticosteroid and LABA inhalers.

The inhaler should be stored at ambient temperature below 25 °C, kept in its original packaging, protected from moisture and direct sunlight, and out of reach of children. Do not expose the device to extreme heat or humidity.

The patient removes the cap, exhales fully away from the device, then inhales quickly and deeply through the mouthpiece. After inhalation, the breath is held for several seconds to allow optimal drug deposition. No coordination of actuation and inhalation is required with the Nexthaler.

Serious risks include paradoxical bronchospasm, adrenal suppression with prolonged high‑dose use, severe allergic reactions such as anaphylaxis, and cardiac arrhythmias. Patients should seek immediate medical attention if they experience worsening breathlessness, rash, swelling, or irregular heartbeat.

Kantos Nexthaler is contraindicated in individuals with known hypersensitivity to beclometasone, formoterol, or any excipients. It should also be avoided in patients with untreated severe cardiovascular disorders and in those who have experienced a life‑threatening asthma attack requiring mechanical ventilation.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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