Kaogram (Propamidine Isetionate)

Propamidine isetionate belongs to the diamidine class of antiseptics. It binds to microbial DNA, disrupting replication and transcription processes. This interference halts protein synthesis, leading to cell death of bacteria and certain protozoa, thereby providing broad‑spectrum antimicrobial activity in the eye.

The dosing regimen for Kaogram is determined by the prescribing ophthalmologist based on the specific indication, severity of infection, and patient factors. The prescriber will specify the number of drops, frequency, and duration of treatment appropriate for each case.

Safety data for propamidine isetionate in pregnancy and lactation are limited. It should be used only if the potential benefit justifies any potential risk to the fetus or infant. Healthcare providers should evaluate the clinical situation before prescribing to pregnant or nursing patients.

To request Kaogram, submit an enquiry on the product page at gnhindia.com, indicating the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide. After submission, the sales team will verify trade or institutional credentials and respond with pricing, availability, shipping details and any required import documentation.

Kaogram’s active ingredient, propamidine isetionate, offers a broad‑spectrum diamidine mechanism distinct from agents such as chlorhexidine or polyhexamethylene biguanide (PHMB). While all provide antimicrobial activity, propamidine may have a different safety profile and efficacy against Acanthamoeba species, making it a preferred option in certain protozoal infections.

Kaogram should be stored at temperatures below 25 °C, protected from light, moisture and extreme temperature fluctuations. Keep the product in its original sealed container until use. Do not freeze the solution, and avoid exposing it to direct sunlight or humid environments.

Kaogram is applied topically to the eye as a sterile solution. The prescribed number of drops is instilled into the conjunctival sac, typically without touching the tip of the bottle to the eye or surrounding tissues. Patients should wash their hands before and after administration and avoid contact lens use until advised.

Serious adverse reactions, though rare, can include allergic contact dermatitis of the eyelid, corneal ulceration or epithelial defects, and severe ocular inflammation such as uveitis. Prompt medical evaluation is required if any of these symptoms develop during treatment.

Kaogram is contraindicated in individuals with a known hypersensitivity to propamidine, other diamidines, or any component of the formulation. Patients with active severe ocular surface disease unrelated to infection should consult their ophthalmologist before use. Contact lens wearers should follow specific guidance regarding lens removal during treatment.