Product image of Kapake (Paracetamol, Codeine Phosphate) supplied by GNH India

Kapake

Active Ingredient:
Paracetamol, Codeine Phosphate
Origin:
EU

Kapake (Paracetamol, Codeine Phosphate)

Paracetamol and Codeine Phosphate, the active ingredient in Kapake, is an analgesic (combination opioid and non‑opioid) presented as an oral tablet for systemic use. It treats moderate to severe pain in adults, providing both antipyretic and opioid‑mediated relief.

GNH India supplies Kapake as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Athlone Pharmaceuticals Limited

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Indications & Clinical Uses

Kapake, containing paracetamol and codeine phosphate, is indicated for pain management across several clinical situations.

  • Acute postoperative pain: provides effective analgesia after surgical procedures.
  • Dental pain: reduces discomfort following extractions or other dental work.
  • Musculoskeletal pain: alleviates pain from sprains, strains, or osteoarthritis flare‑ups.

How It Works

  • Paracetamol acts centrally to inhibit prostaglandin synthesis, producing antipyretic and analgesic effects, while codeine phosphate binds to mu‑opioid receptors in the central nervous system, triggering analgesia and modest antitussive activity. The combination yields additive pain relief through distinct pharmacologic pathways.

Side Effects

Kapake may cause a range of adverse reactions, most of which are mild and reversible.

Common Side Effects

  • Nausea: mild to moderate stomach upset.
  • Constipation: reduced bowel motility.
  • Drowsiness: increased sleepiness.
  • Dizziness: sensation of light‑headedness.
  • Vomiting: occasional emesis.
  • Sweating: excessive perspiration.

Serious or Rare Side Effects

  • Respiratory depression: reduced breathing effort, especially at high doses.
  • Dependence or addiction: potential for misuse with prolonged use.
  • Allergic reactions: rash, itching, or angioedema.
  • Hepatic injury: rare liver enzyme elevation.
  • Seizures: infrequent but possible in susceptible individuals.
  • Severe hypotension: marked drop in blood pressure.

Precautions & Warnings

When prescribing Kapake, clinicians should consider several safety measures.

  • Assess pain severity: ensure the combination is appropriate for the level of pain.
  • Avoid in severe respiratory depression: risk of further breathing compromise.
  • Monitor for dependence: watch for signs of misuse with prolonged therapy.
  • Use caution in hepatic impairment: paracetamol metabolism may be reduced.
  • Avoid concomitant CNS depressants: increased sedation risk.
  • Store at ambient temperature: keep in the original pack, protect from moisture.

Avoid Interactions

Kapake can interact with other medicines, requiring careful management.

Major Interactions (Avoid)

  • Other opioids: additive respiratory depression.
  • Benzodiazepines or CNS depressants: heightened sedation and respiratory risk.
  • Alcohol: increased central nervous system depression.

Moderate Interactions (Monitor Closely)

  • CYP2D6 inhibitors (e.g., fluoxetine): may raise codeine levels.
  • Antidepressants (SSRIs/SNRIs): potential for serotonin syndrome.
  • Antihistamines: may enhance drowsiness.

Frequently Asked Questions

Kapake is a prescription oral tablet that combines paracetamol and codeine phosphate to relieve moderate to severe pain. It is commonly used after surgery, dental procedures, or for musculoskeletal conditions where stronger analgesia than paracetamol alone is required.

Paracetamol reduces pain by inhibiting central prostaglandin synthesis, while codeine phosphate activates mu‑opioid receptors in the brain and spinal cord, providing opioid‑mediated analgesia and a mild cough‑suppressing effect. The two mechanisms act together to enhance overall pain control.

The specific dose of Kapake is determined by the prescribing clinician based on the patient’s pain intensity, medical history, and other medications. Only a qualified health professional should set the dosage and frequency.

Safety of Kapake in pregnancy or lactation has not been fully established. Health professionals should weigh potential benefits against risks and consider alternative therapies when treating pregnant or nursing individuals.

To request Kapake, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Kapake offers stronger analgesia than paracetamol alone because of the added opioid component, but it carries a higher risk of opioid‑related side effects compared with non‑opioid NSAIDs. It is often chosen when moderate to severe pain cannot be controlled by single‑agent non‑opioid analgesics.

Kapake tablets should be stored at ambient temperature, below 25 °C, in the original container to protect them from moisture and light. Keep the product out of reach of children.

Kapake is taken orally with a full glass of water. It may be taken with or without food, but patients should follow the prescribing clinician’s instructions regarding timing and whether to avoid certain foods or beverages.

The most serious risks include respiratory depression, especially in high‑dose or opioid‑naïve patients, potential for dependence or addiction with prolonged use, and rare severe allergic reactions such as angioedema. Patients should seek immediate medical attention if they experience breathing difficulties or signs of an allergic response.

Kapake should be avoided in individuals with known hypersensitivity to paracetamol or codeine, severe respiratory depression, uncontrolled asthma, significant liver disease, or in patients currently taking other strong opioids without medical supervision.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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