Product image of Kapetral (Capecitabine) supplied by GNH India

Kapetral

Active Ingredient:
Capecitabine
Origin:
EU

Kapetral (Capecitabine)

Capecitabine, the active ingredient in Kapetral, is an antimetabolite (fluoropyrimidine) presented as an oral tablet for oral use. It is indicated for certain metastatic solid tumours, most commonly colorectal and breast cancer, in adult patients.
GNH India supplies Kapetral as a licensed, GDP‑compliant international pharmaceutical supplier serving oncology centres worldwide.

Manufacturer / TM Owner

Alpha-Medical D.O.O.

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Indications & Clinical Uses

  • Capecitabine is employed in the management of solid tumours that are responsive to fluoropyrimidine therapy.
  • Metastatic colorectal cancer: improves disease control and extends survival when used in combination with other agents.
  • Metastatic breast cancer: provides therapeutic benefit after prior chemotherapy regimens.
  • Adjuvant colon cancer (high‑risk): used to reduce recurrence risk following surgical resection.

How It Works

  • Capecitabine is a pro‑drug that is enzymatically converted to 5‑fluorouracil (5‑FU) preferentially within tumour tissue. 5‑FU inhibits thymidylate synthase, disrupting DNA synthesis, and incorporates into RNA and DNA, leading to impaired nucleic acid function and selective cytotoxicity in rapidly dividing cancer cells.

Side Effects

Capecitabine may cause a range of adverse reactions, from mild to severe.

Common Side Effects

  • Nausea and vomiting
  • Diarrhoea
  • Hand‑foot syndrome (palmar‑plantar erythrodysesthesia)
  • Fatigue
  • Alopecia
  • Decreased appetite

Serious or Rare Side Effects

  • Severe neutropenia or leukopenia
  • Thrombocytopenia
  • Grade 3/4 hand‑foot syndrome
  • Cardiac toxicity (e.g., angina, myocardial infarction)
  • Severe allergic reactions (e.g., Stevens‑Johnson syndrome)
  • Hepatotoxicity

Precautions & Warnings

  • Capecitabine requires careful monitoring and patient education before and during therapy.
  • Renal function: assess creatinine clearance and adjust dose in renal impairment.
  • Hepatic function: monitor liver enzymes; use cautiously in hepatic disease.
  • Cardiac history: avoid in patients with recent myocardial infarction or uncontrolled angina.
  • Pregnancy and lactation: contraindicated unless benefits outweigh risks; discuss with obstetric specialist.
  • Drug interactions: review concomitant medications for potential interactions.
  • Store at ambient temperature: keep in original container, protect from moisture and heat.

Avoid Interactions

Capecitabine can interact with several medicines, altering efficacy or safety.

Major Interactions (Avoid)

  • Strong CYP3A4 inducers (e.g., rifampicin) – may reduce drug exposure.
  • Anticoagulants (warfarin) – increased risk of bleeding.
  • Antiepileptics (phenytoin, carbamazepine) – may lower plasma levels.

Moderate Interactions (Monitor Closely)

  • Fluoropyrimidine antagonists (uridine triacetate) – may affect toxicity management.
  • NSAIDs – heightened gastrointestinal toxicity.
  • St. John’s wort – possible reduction of capecitabine exposure.

Frequently Asked Questions

Kapetral contains capecitabine, an oral chemotherapy agent indicated for the treatment of metastatic colorectal cancer and metastatic breast cancer, as well as for certain high‑risk adjuvant colon cancer settings.

Capecitabine is a pro‑drug that is converted to 5‑fluorouracil inside tumour cells. 5‑fluorouracil blocks thymidylate synthase and incorporates into RNA and DNA, disrupting nucleic‑acid synthesis and leading to selective cancer‑cell death.

The prescribed dose of Kapetral is individualized by the treating oncologist based on the patient’s cancer type, body surface area, renal function and treatment protocol. Only a qualified prescriber should determine the dosing schedule.

Capecitabine is generally contraindicated in pregnancy because of potential fetal harm. Women of child‑bearing potential should use effective contraception. Breastfeeding is not recommended while receiving Kapetral, and the infant should not be exposed to the drug.

To request Kapetral, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Kapetral (capecitabine) offers the convenience of oral administration compared with intravenous 5‑fluorouracil. Both deliver the same active metabolite, but capecitabine provides more continuous exposure and avoids infusion‑related complications, while sharing a similar safety profile.

Kapetral should be stored at ambient temperature, below 25 °C, in its original packaging. Keep the tablets away from moisture, direct sunlight and excessive heat to maintain stability.

Kapetral is taken orally, usually twice daily on scheduled treatment days, with food or a light snack to reduce gastrointestinal irritation. The exact schedule is defined by the prescribing oncologist.

Serious risks include severe neutropenia, thrombocytopenia, high‑grade hand‑foot syndrome, cardiac events such as angina or myocardial infarction, and rare but life‑threatening allergic reactions. Patients should be monitored closely for these events.

Kapetral should not be used by patients with known hypersensitivity to capecitabine or other fluoropyrimidines, those with severe renal or hepatic impairment without dose adjustment, and individuals with recent significant cardiac disease unless the benefits clearly outweigh the risks.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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