Karbamid Evolan (Urea)

Urea acts as a hygroscopic agent that draws water into the outer skin layers, increasing hydration. It also disrupts hydrogen bonds in keratin, producing a mild keratolytic effect that softens thickened skin. This dual action helps restore a smoother, more flexible epidermis.

The dosage of Karbamid Evolan is determined by the prescribing healthcare professional based on the specific skin condition, severity, and patient age. Typically, a thin layer is applied to the affected area once or twice daily, but exact instructions should always follow the prescriber’s guidance.

Safety data for topical urea in pregnancy and lactation are limited. Women who are pregnant or breastfeeding should discuss use with their healthcare provider, who can weigh potential benefits against any theoretical risks and decide whether the product is appropriate for them.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, and will request verification of trade or institutional credentials before providing pricing, availability, shipping details and any necessary import documentation.

Compared with simple emollients, Karbamid Evolan adds a keratolytic component through urea, which not only hydrates but also gently exfoliates thickened skin. This makes it more effective for conditions like ichthyosis or keratosis pilaris, whereas standard moisturizers primarily provide surface hydration without keratolysis.

Store Karbamid Evolan at ambient temperature, preferably below 25 °C. Keep the product in its original packaging, protect it from moisture and direct sunlight, and ensure the container is tightly closed to maintain stability and potency.

Apply a thin layer of the cream or ointment to clean, dry skin on the affected area. Gently massage until fully absorbed, usually once or twice daily as directed by a healthcare professional. Avoid contact with eyes and mucous membranes.

The most serious risks are rare allergic reactions, such as severe contact dermatitis, swelling, hives or difficulty breathing, which require immediate medical attention. In very uncommon cases, extensive blistering or bullous dermatitis may occur, especially with over‑use or in highly sensitive individuals.

Individuals with known hypersensitivity to urea or any excipients in the formulation should avoid using Karbamid Evolan. It should also not be applied to open wounds, infected skin, or areas with severe eczema without medical advice, as irritation risk may be heightened.