Product image of Karbamid/Glycerol Aco (Glycerol, Urea) supplied by GNH India

Karbamid/Glycerol Aco

Active Ingredient:
Glycerol, Urea
Origin:
EU

Karbamid/Glycerol Aco (Glycerol, Urea)

Urea and Glycerol, the active ingredients in Karbamid/Glycerol Aco, are dermatologic agents presented as a topical preparation for cutaneous use. They help soften dry, scaly skin and improve hydration in conditions such as xerosis, ichthyosis, keratosis pilaris, and eczema.

GNH India supplies Karbamid/Glycerol Aco as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Aco Hud Nordic Ab

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Indications & Clinical Uses

Karbamid/Glycerol Aco is applied to the skin to manage disorders characterized by excessive dryness and keratin buildup.

  • Dry skin (xerosis): restores moisture and reduces scaling.
  • Ichthyosis: softens thickened plaques and improves skin texture.
  • Keratosis pilaris: smooths follicular bumps and lessens roughness.
  • Eczema: alleviates dryness and supports barrier function.

How It Works

  • Urea acts as a keratolytic agent that disrupts hydrogen bonds in keratin, facilitating desquamation and softening of hyperkeratotic skin. Glycerol functions as a humectant, attracting water molecules into the stratum corneum and enhancing epidermal hydration, which together improve skin pliability and barrier integrity.

Side Effects

Topical application of Karbamid/Glycerol Aco may cause local reactions.

Common Side Effects

  • Stinging or burning sensation at the application site.
  • Mild itching or irritation.
  • Transient redness.
  • Dryness or flaking after initial use.
  • Contact dermatitis in sensitive individuals.

Serious or Rare Side Effects

  • Severe allergic reaction (e.g., swelling, hives, difficulty breathing).
  • Persistent skin ulceration or erosions.
  • Widespread rash or bullous formation.
  • Secondary infection of compromised skin.
  • Unusual discoloration of the skin.

Precautions & Warnings

Before using Karbamid/Glycerol Aco, consider the following precautions.

  • Assess skin integrity: avoid on open wounds or infected areas.
  • Test for sensitivity: apply a small amount to a limited area first.
  • Combine with other keratolytics cautiously to prevent excessive irritation.
  • Use under medical supervision in pediatric or elderly patients.
  • Discontinue if severe irritation or allergic signs develop.
  • Store at ambient temperature: keep in original container, protect from moisture and direct sunlight.

Avoid Interactions

Karbamid/Glycerol Aco has limited systemic interactions, but topical co‑applications may affect tolerability.

Major Interactions (Avoid)

  • Concurrent use with strong topical steroids or other potent keratolytics may cause severe irritation.
  • Application over areas treated with chemical peels can exacerbate skin damage.

Moderate Interactions (Monitor Closely)

  • Use with occlusive dressings may increase absorption and irritation risk.
  • Combining with other moisturizers containing alcohol could enhance drying effects.
  • Co‑application with topical antibiotics should be monitored for potential sensitization.

Frequently Asked Questions

Karbamid/Glycerol Aco is a topical formulation containing urea and glycerol that is used to manage dry skin conditions such as xerosis, ichthyosis, keratosis pilaris, and mild to moderate eczema. It works by softening thickened skin and improving hydration, helping to reduce scaling, roughness, and discomfort associated with these dermatologic disorders.

Urea acts as a keratolytic, breaking down excess keratin and facilitating the shedding of dry, scaly skin. Glycerol is a humectant that draws water into the outer skin layer, increasing moisture content and enhancing barrier function. Together they provide both exfoliation and hydration, leading to smoother, more supple skin.

The appropriate amount and frequency of application are determined by the prescribing healthcare professional based on the severity of the skin condition, patient age, and treatment response. Typically, a thin layer is applied to the affected area once or twice daily, but exact instructions should follow the prescriber’s guidance.

There is limited specific data on the use of topical urea‑glycerol preparations during pregnancy or lactation. Because systemic absorption is minimal, it is generally considered low risk, but healthcare providers should evaluate the benefit‑risk ratio for each individual and advise accordingly.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, and will request verification of trade or institutional credentials. After confirmation, the sales team provides pricing, availability, shipping details (including any temperature requirements), and assists with import documentation.

Compared with simple emollients, Karbamid/Glycerol Aco combines a keratolytic (urea) with a humectant (glycerol), offering both exfoliation of hyperkeratotic skin and enhanced hydration. This dual action can be more effective for conditions like ichthyosis or keratosis pilaris, where ordinary moisturizers may not sufficiently soften thickened plaques.

Store Karbamid/Glycerol Aco at ambient temperature, preferably below 25 °C. Keep the container tightly closed, protect it from moisture and direct sunlight, and avoid freezing. Ensure the packaging remains intact to maintain product stability.

The product is applied topically to clean, dry skin. A thin layer should be spread over the affected area and gently massaged until absorbed. Frequency of application (once or twice daily) depends on the prescriber’s instructions and the severity of the skin condition.

The most serious risks include severe allergic reactions such as anaphylaxis, extensive skin irritation leading to ulceration, and secondary infection of compromised skin. Users should discontinue the product and seek medical attention immediately if they experience swelling, difficulty breathing, widespread rash, or signs of infection.

Individuals with known hypersensitivity to urea, glycerol, or any excipients in the formulation should avoid using the product. It should also not be applied to open wounds, infected skin, or areas where a strong keratolytic or irritant is already in use without medical supervision.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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