Product image of Karbamid Net (Urea) supplied by GNH India

Karbamid Net

Active Ingredient:
Urea
Origin:
EU

Karbamid Net (Urea)

Urea, the active ingredient in Karbamid Net, is a keratolytic presented as a topical preparation for skin use. It increases water content of the stratum corneum and softens hyperkeratotic skin, making it useful in conditions such as dry skin, psoriasis and ichthyosis across the EU market.

GNH India supplies Karbamid Net as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides reliable global distribution for this dermatological product.

Manufacturer / TM Owner

Evolan Pharma Ab

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Indications & Clinical Uses

Karbamid Net, a topical keratolytic, is employed to manage disorders characterized by dry or thickened skin.

  • Dry skin (xerosis): improves hydration and reduces scaling
  • Psoriasis plaques: softens plaques and facilitates descaling
  • Ichthyosis: enhances skin moisture and reduces roughness
  • Callus or hyperkeratotic areas: promotes gradual thinning of thickened skin

How It Works

  • Urea acts as both a keratinolytic and a humectant. It disrupts hydrogen bonds within keratin, leading to breakdown of excess corneocyte cohesion, while simultaneously attracting water into the stratum corneum. The combined actions increase epidermal hydration, soften the horny layer and facilitate desquamation of hyperkeratotic tissue, resulting in smoother, more pliable skin.

Side Effects

Topical urea may cause local skin reactions, ranging from mild irritation to rare severe events.

Common Side Effects

  • Mild burning sensation: transient discomfort at application site
  • Skin redness (erythema): mild and usually resolves
  • Itching (pruritus): occasional mild itch
  • Dryness or peeling: mild desquamation

Serious or Rare Side Effects

  • Allergic contact dermatitis: rash, swelling, and intense itching
  • Severe skin irritation: blistering or ulceration
  • Systemic toxicity: rare, may present with nausea if large areas are applied
  • Excessive swelling (angioedema): rare but requires medical attention

Precautions & Warnings

When using Karbamid Net, observe the following safety measures to minimize adverse reactions.

  • Avoid application on broken or inflamed skin: may increase irritation
  • Do not combine with other strong keratolytics unless directed: risk of excessive skin damage
  • Perform a patch test on a small area before full use: identify sensitivity
  • Keep away from eyes and mucous membranes: avoid accidental contact
  • Store at room temperature: keep in original container, protect from moisture and direct sunlight

Avoid Interactions

Urea can interact with certain topical agents, affecting skin tolerance or absorption.

Major Interactions (Avoid)

  • Concurrent use with potent topical corticosteroids: may enhance systemic absorption of urea
  • Application together with other keratolytic agents (e.g., salicylic acid) without supervision: risk of severe irritation

Moderate Interactions (Monitor Closely)

  • Use with alcohol‑based cleansers: may increase drying effect
  • Occlusive dressings over treated area: can intensify urea penetration and irritation
  • Co‑administration with systemic retinoids: may heighten skin sensitivity

Frequently Asked Questions

Karbamid Net is a topical keratolytic containing urea. It is used to soften and hydrate dry, scaly or hyperkeratotic skin, helping conditions such as xerosis, psoriasis plaques, ichthyosis and thickened callus areas.

Urea works by breaking hydrogen bonds in keratin, which reduces the cohesion of excess skin cells, and by acting as a humectant that draws water into the outer skin layer. This dual action increases moisture, softens the horny layer and promotes gentle desquamation.

The appropriate amount of Karbamid Net is determined by the prescribing healthcare professional based on the specific skin condition, area to be treated and patient tolerance. No fixed dosing regimen is provided here.

Safety data for topical urea in pregnancy and lactation are limited. Healthcare providers should evaluate the risk‑benefit profile for each individual. Women who are pregnant or breastfeeding should consult their physician before using the product.

To place an enquiry, visit the product page on gnhindia.com, enter the required quantity and submit the request. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Karbamid Net uses urea, which combines keratolytic and humectant properties, offering both exfoliation and moisturisation. Compared with salicylic acid or glycolic acid, urea is generally milder, causing less irritation while still effectively softening hyperkeratotic skin.

Store Karbamid Net at room temperature, preferably below 25 °C. Keep the container tightly closed, protect it from moisture and direct sunlight, and ensure it is out of reach of children.

Apply a thin layer of the product to the affected skin area, usually once or twice daily, or as directed by a healthcare professional. Gently massage until absorbed, avoiding contact with eyes, mucous membranes and broken skin unless instructed otherwise.

Serious but rare risks include allergic contact dermatitis, severe skin irritation leading to blistering or ulceration, and, in extensive applications, systemic toxicity. If any severe reaction occurs, discontinue use and seek medical attention promptly.

Individuals with known hypersensitivity to urea or any excipients in the formulation should avoid using Karbamid Net. It should also not be applied to open wounds, severely inflamed skin, or mucous membranes without medical advice.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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