Product image of Karbetocin Avmc (Carbetocin) supplied by GNH India

Karbetocin Avmc

Active Ingredient:
Carbetocin
Origin:
EU

Karbetocin Avmc (Carbetocin)

Carbetocin, the active ingredient in Karbetocin Avmc, is an oxytocin analog presented as an injectable solution for intravenous use. It is employed to prevent and treat postpartum hemorrhage and uterine atony in women after delivery.

GNH India supplies Karbetocin Avmc as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide.

Manufacturer / TM Owner

Av Medical Cz S.R.O.

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Indications & Clinical Uses

Karbetocin is an oxytocin‑type uterotonic used in obstetric care to control bleeding.

  • Postpartum hemorrhage: reduces excessive bleeding after vaginal or cesarean delivery.
  • Uterine atony: stimulates uterine smooth‑muscle contraction to restore tone.
  • Obstetric surgery: supports uterine contraction during and after surgical procedures to minimise blood loss.

How It Works

  • Carbetocin acts as a selective agonist at oxytocin receptors on uterine smooth muscle. Binding triggers intracellular calcium release, leading to coordinated myometrial contractions that compress uterine blood vessels, thereby reducing postpartum bleeding. Its longer half‑life compared with native oxytocin provides sustained uterine tone after a single intravenous dose.

Side Effects

Carbetocin may cause a range of adverse reactions. Monitoring for side effects is part of routine clinical care.

Common Side Effects

  • Nausea: mild to moderate upset stomach.
  • Headache: transient cranial discomfort.
  • Flushing: temporary redness of skin.
  • Transient hypotension: brief drop in blood pressure.

Serious or Rare Side Effects

  • Severe hypertension: marked elevation of blood pressure requiring intervention.
  • Cardiac arrhythmia: abnormal heart rhythm.
  • Allergic reaction: rash, itching, or anaphylaxis.
  • Uterine rupture: rare but life‑threatening tearing of the uterus.

Precautions & Warnings

Before using Karbetocin, clinicians should consider several safety aspects.

  • Cardiovascular status: assess blood pressure and heart rhythm.
  • Fluid balance: monitor for signs of fluid overload.
  • Pre‑existing uterine conditions: evaluate for scar tissue or previous rupture.
  • Concomitant uterotonics: avoid simultaneous use with other agents that increase uterine tone.
  • Allergies: verify no known hypersensitivity to carbetocin or oxytocin analogs.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze.

Avoid Interactions

Carbetocin can interact with other medications that affect cardiovascular or uterine function.

Major Interactions (Avoid)

  • Vasopressors (e.g., epinephrine): may exacerbate hypertension.
  • Magnesium sulfate: can potentiate uterine relaxation, reducing efficacy.

Moderate Interactions (Monitor Closely)

  • Antihypertensives: may enhance blood‑pressure lowering effect.
  • Other uterotonics (e.g., oxytocin, misoprostol): increase risk of uterine hyperstimulation.
  • Anesthetic agents: may alter hemodynamic response during surgery.

Frequently Asked Questions

Karbetocin Avmc is used to prevent and treat postpartum hemorrhage and to manage uterine atony after childbirth. It works by stimulating uterine contractions, helping to control bleeding in the immediate postpartum period.

Carbetocin is an oxytocin receptor agonist. By binding to oxytocin receptors on the uterus, it triggers calcium‑mediated muscle contraction, which compresses uterine blood vessels and reduces postpartum bleeding.

The dose of Karbetocin Avmc is determined by the prescribing clinician based on the patient’s clinical situation, weight, and local guidelines. Healthcare professionals should follow the recommended dosing instructions on the product label.

Karbetocin Avmc is intended for use after delivery, not during pregnancy. Its safety in breastfeeding has not been fully established, so clinicians should weigh potential benefits against risks and consider alternative therapies when appropriate.

To order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain where needed), and import documentation.

Compared with native oxytocin, carbetocin has a longer half‑life, allowing a single intravenous dose to maintain uterine tone for a longer period. It offers similar efficacy to oxytocin but with potentially fewer repeat dosing requirements.

Karbetocin Avmc should be stored at 2‑8 °C in a refrigerator, protected from light, and must not be frozen or shaken. Keep the product in its original packaging to maintain stability.

The medication is given by intravenous injection, typically as a single dose administered by a qualified healthcare professional in a controlled clinical setting.

Serious risks include severe hypertension, cardiac arrhythmias, and rare uterine rupture. Immediate medical attention is required if any of these events occur during or after administration.

Patients with known hypersensitivity to carbetocin or other oxytocin analogs, those with uncontrolled hypertension, or individuals with a history of uterine rupture should avoid using Karbetocin Avmc. Clinicians must assess each patient’s medical history before prescribing.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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