Product image of Karbolan (Urea) supplied by GNH India

Karbolan

Active Ingredient:
Urea
Origin:
EU

Karbolan (Urea)

Urea, the active ingredient in Karbolan, is a keratolytic presented as a topical preparation for skin use. It helps to soften and hydrate hyperkeratotic lesions, making it useful for conditions such as hyperkeratosis, ichthyosis, dry skin and psoriasis in adults and children.
GNH India supplies Karbolan as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Evolan Pharma Ab

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Indications & Clinical Uses

  • Karbolan is a topical keratolytic used to manage disorders characterized by excessive keratin buildup.
  • Hyperkeratosis: reduces thickness and scaling of hyperkeratotic plaques.
  • Ichthyosis: improves skin smoothness and reduces scaling.
  • Dry skin: enhances hydration and softness of rough skin.
  • Psoriasis: helps to soften plaques and lessen scaling.

How It Works

  • Urea acts as a keratolytic by disrupting hydrogen bonds within keratin fibers, leading to keratinolysis. This process increases water binding in the stratum corneum, improves skin hydration, and softens hyperkeratotic lesions, facilitating their removal and restoring a more normal skin texture.

Side Effects

Karbolan may cause local skin reactions, most of which are mild and reversible.

Common Side Effects

  • Skin irritation or burning sensation.
  • Itching or mild pruritus.
  • Redness or erythema at the application site.
  • Dryness or peeling of the treated skin.

Serious or Rare Side Effects

  • Allergic contact dermatitis with swelling or vesiculation.
  • Severe urticaria or widespread rash.
  • Blistering or extensive skin breakdown requiring medical attention.

Precautions & Warnings

  • Before using Karbolan, consider the following safety measures.
  • Pregnancy: consult a healthcare professional before use.
  • Breastfeeding: use with caution and under medical advice.
  • Skin integrity: avoid application on open wounds or severely damaged skin.
  • Allergy: discontinue immediately if signs of allergic reaction appear.
  • Store at ambient temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Karbolan may interact with other topical agents; monitor for increased irritation.

Major Interactions (Avoid)

  • Concurrent use of strong topical steroids may heighten skin irritation.
  • Combination with other keratolytics such as salicylic acid can cause excessive peeling.

Moderate Interactions (Monitor Closely)

  • Occlusive dressings may increase systemic absorption.
  • Alcohol‑based cleansers can enhance dryness when used together.
  • Phototherapy may increase photosensitivity of treated areas.

Frequently Asked Questions

Karbolan is a topical keratolytic indicated for the management of hyperkeratosis, ichthyosis, dry skin and psoriasis. It helps to soften thickened skin, reduce scaling and improve overall skin texture in these dermatologic conditions.

Urea works by breaking hydrogen bonds within keratin, promoting keratinolysis and increasing water retention in the stratum corneum. This dual action softens hyperkeratotic plaques, enhances skin hydration and facilitates the removal of excess keratin.

The dosage of Karbolan is determined by the prescribing healthcare professional based on the specific condition, severity and patient characteristics. The prescriber will advise the appropriate amount and frequency of topical application.

Karbolan is classified as an OTC topical product. While systemic exposure is minimal, pregnant or breastfeeding individuals should consult their healthcare provider before using it to ensure it is appropriate for their situation.

To order Karbolan, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Karbolan’s urea‑based formulation offers both keratolytic and humectant properties, which can be gentler than stronger acids like salicylic acid. It provides effective softening of hyperkeratotic lesions while maintaining skin hydration, making it suitable for patients who need a milder yet effective option.

Karbolan should be stored at ambient temperature, preferably below 25 °C. Keep the product in its original packaging, protect it from moisture and direct sunlight, and ensure the container is tightly closed when not in use.

Karbolan is applied topically to the affected skin area. Clean and gently dry the skin, then spread a thin layer of the product as directed by the prescriber, usually once or twice daily, and allow it to absorb before covering the area.

The most serious risks include allergic contact dermatitis, severe skin swelling, blistering or widespread rash. If any of these reactions occur, discontinue use immediately and seek medical attention.

Karbolan should not be used on broken or infected skin, in individuals with a known hypersensitivity to urea or any excipients in the formulation, and it is contraindicated in patients where a healthcare professional advises against its use.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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