Product image of Karnodyl (Propranolol Hydrochloride) supplied by GNH India

Karnodyl

Active Ingredient:
Propranolol Hydrochloride
Origin:
EU

Karnodyl (Propranolol Hydrochloride)

Propranolol, the active ingredient in Karnodyl, is a beta blocker presented as an injection for intravenous use. It treats hypertension, angina pectoris, myocardial infarction, cardiac arrhythmias, migraine prophylaxis, and essential tremor in adult patients.

GNH India supplies Karnodyl as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Efiscienslimited

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Indications & Clinical Uses

  • Propranolol is a non‑selective beta‑adrenergic blocker used in several cardiovascular and neurological conditions.
  • Hypertension: lowers blood pressure by reducing heart rate, contractility and renin release.
  • Angina pectoris: decreases myocardial oxygen demand, relieving chest pain.
  • Myocardial infarction: improves survival by limiting arrhythmias and cardiac workload.
  • Cardiac arrhythmias: controls heart rate and stabilises rhythm in various arrhythmic disorders.
  • Migraine prophylaxis: reduces frequency and severity of migraine attacks.
  • Essential tremor: diminishes tremor amplitude in affected patients.

How It Works

  • Propranolol acts as a non‑selective antagonist of β1 and β2 adrenergic receptors. By blocking β1 receptors in the heart, it reduces heart rate, myocardial contractility and renin release, leading to lower cardiac output and blood pressure. β2 blockade in peripheral vessels and bronchial smooth muscle contributes to decreased peripheral resistance and can affect respiratory tone. These combined actions underlie its antihypertensive, anti‑anginal, anti‑arrhythmic, migraine‑preventive, and tremor‑reducing effects.

Side Effects

Common Side Effects

  • Fatigue or general weakness
  • Dizziness or light‑headedness
  • Bradycardia (slow heart rate)
  • Cold extremities or peripheral vasoconstriction
  • Nausea, abdominal discomfort or diarrhoea
  • Sleep disturbances or vivid dreams

Serious or Rare Side Effects

  • Severe bradycardia or heart block
  • Marked hypotension
  • Bronchospasm or severe asthma exacerbation
  • Acute heart failure decompensation
  • Hypoglycaemia unawareness in diabetic patients
  • Anaphylactic or severe allergic reactions

Precautions & Warnings

Before initiating Karnodyl, clinicians should evaluate patient‑specific risk factors and monitor appropriately.

  • Cardiovascular assessment: monitor heart rate and blood pressure regularly.
  • Respiratory conditions: avoid in patients with active asthma or severe COPD due to bronchospasm risk.
  • Diabetes management: watch for masked hypoglycaemia symptoms.
  • Concomitant drugs: review for additive bradycardic or hypotensive effects.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Propranolol may interact with several medicines; careful review is required.

Major Interactions (Avoid)

  • Calcium channel blockers (verapamil, diltiazem): risk of profound bradycardia and AV block.
  • Insulin or oral hypoglycemics: may conceal hypoglycaemia signs.
  • Clonidine abrupt withdrawal: can cause rebound hypertension.
  • MAO inhibitors: potential for hypertensive crisis.

Moderate Interactions (Monitor Closely)

  • Diuretics: enhanced hypotensive effect, monitor fluid status.
  • Antidepressants (SSRIs, tricyclics): possible additive cardiac effects, observe heart rhythm.

Frequently Asked Questions

Karnodyl contains propranolol, a non‑selective beta‑blocker indicated for hypertension, angina pectoris, myocardial infarction, various cardiac arrhythmias, migraine prophylaxis, and essential tremor. It is administered intravenously in hospital or clinical settings under physician supervision.

Propranolol blocks β1 and β2 adrenergic receptors, reducing heart rate, myocardial contractility, and renin release. This lowers cardiac output and blood pressure, decreases myocardial oxygen demand, stabilises heart rhythm, and can prevent migraine attacks and tremor by modulating sympathetic activity.

The specific dose and infusion rate of Karnodyl are determined by the prescribing clinician based on the patient’s condition, severity, and response. Healthcare professionals adjust the regimen according to clinical guidelines and individual therapeutic needs.

The safety of propranolol during pregnancy or lactation is not fully established. It should only be used if the potential benefit justifies the potential risk to the fetus or infant, and the decision must be made by a qualified healthcare provider.

To order Karnodyl, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain where needed) and import documentation.

Karnodyl (propranolol) is a non‑selective beta‑blocker, affecting both β1 and β2 receptors, whereas many alternatives such as metoprolol or atenolol are β1‑selective. This broader activity can be advantageous for migraine prophylaxis and tremor but may increase the risk of bronchospasm in patients with reactive airway disease.

Karnodyl should be stored at 2‑8 °C, protected from light, and kept in its original packaging. Do not freeze or shake the vial. If the product reaches room temperature, return it to refrigerated conditions promptly to maintain stability.

Karnodyl is supplied as an injectable solution for intravenous use. It is administered by a qualified healthcare professional, typically as a slow infusion or bolus, according to the prescribed dose and clinical protocol.

Serious risks include severe bradycardia, hypotension, bronchospasm, heart block, and masking of hypoglycaemia in diabetic patients. Immediate medical attention is required if any of these events occur during therapy.

Karnodyl is contraindicated in patients with known hypersensitivity to propranolol or any component of the formulation, in those with severe asthma or chronic obstructive pulmonary disease, and in individuals with uncompensated heart block or severe bradycardia without a pacemaker.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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