Karon (Alprostadil)

Alprostadil activates adenylate cyclase in the corpus cavernosum, increasing intracellular cAMP. The rise in cAMP causes smooth‑muscle relaxation and vasodilation, which enhances blood flow to produce an erection.

The dose of alprostadil is individualized by the prescribing physician based on clinical response and tolerability. The prescriber determines the appropriate starting and maintenance doses for each patient.

Alprostadil is intended for use in adult men with erectile dysfunction. Safety in pregnancy or breastfeeding has not been established, and it is not indicated for use in these populations.

Submit an enquiry on the Karon product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain where required) and import documentation.

The primary alternative class is phosphodiesterase‑5 inhibitors such as sildenafil. Unlike oral PDE‑5 inhibitors, alprostadil is an injectable prostaglandin that directly induces vasodilation, making it useful when oral agents are ineffective, contraindicated, or when a rapid onset of action is desired.

Karon should be stored at 2‑8 °C in a refrigerator, protected from light, and must not be frozen or shaken. Use aseptic technique when preparing the injection, and keep the product in its original packaging until use.

Karon is administered by intracavernous injection directly into the corpus cavernosum of the penis using a sterile syringe, as directed by a qualified healthcare professional.

The most serious risks include prolonged priapism lasting more than four hours, severe hypotension, and allergic reactions such as anaphylaxis. Immediate medical attention is required if any of these events occur.

Men with known hypersensitivity to alprostadil or other prostaglandins, those with severe penile anatomical abnormalities, and patients with certain cardiovascular conditions should avoid Karon unless cleared by a physician.