Product image of Kartesada (Pregabalin) supplied by GNH India

Kartesada

Active Ingredient:
Pregabalin
Origin:
EU

Kartesada (Pregabalin)

Pregabalin, the active ingredient in Kartesada, is a gabapentinoid presented as an oral tablet for oral use. It is employed to manage neuropathic pain conditions and as adjunctive therapy for partial seizures in adults. The medication works by modulating calcium channel activity, which helps reduce abnormal neuronal firing associated with pain and seizure activity.

GNH India supplies Kartesada as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides regulatory documentation for global distribution.

Manufacturer / TM Owner

Egis Pharmaceuticals Plc

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Indications & Clinical Uses

Pregabalin is indicated for several neurological and pain‑related conditions where modulation of calcium channels provides therapeutic benefit.

  • Diabetic peripheral neuropathy: reduces pain intensity and improves sensory function.
  • Postherpetic neuralgia: alleviates chronic burning pain after shingles.
  • Fibromyalgia: lessens widespread musculoskeletal pain and improves functional capacity.
  • Partial onset seizures: provides adjunctive seizure control in adults.

How It Works

  • Pregabalin binds selectively to the α2‑δ subunit of voltage‑gated calcium channels in the central nervous system. This binding decreases calcium influx into hyper‑excited neurons, leading to reduced release of excitatory neurotransmitters such as glutamate, norepinephrine, and substance P, thereby dampening neuronal hyper‑excitability associated with pain and seizures.

Side Effects

Pregabalin may cause a range of adverse reactions, which are categorized by frequency and severity.

Common Side Effects

  • Dizziness
  • Somnolence
  • Peripheral edema
  • Weight gain
  • Blurred vision
  • Dry mouth

Serious or Rare Side Effects

  • Angioedema or severe allergic reactions
  • Suicidal thoughts or behavior
  • Respiratory depression, especially with CNS depressants
  • Severe skin reactions such as Stevens‑Johnson syndrome
  • Blood dyscrasias (e.g., agranulocytosis)
  • Hepatic dysfunction

Precautions & Warnings

When prescribing Pregabalin, clinicians should consider several safety factors.

  • Renal impairment: dose adjustment may be required due to renal excretion.
  • Pregnancy: Category C; weigh potential benefits against risks.
  • Elderly patients: increased sensitivity to CNS effects; start low and titrate slowly.
  • Concomitant CNS depressants: may enhance sedation and respiratory depression.
  • Abrupt discontinuation: risk of rebound hyperexcitability; taper gradually.
  • Store at ambient temperature: keep below 25°C, protect from moisture and direct sunlight.

Avoid Interactions

Pregabalin can interact with other medicines, affecting safety or efficacy.

Major Interactions (Avoid)

  • Opioids: additive risk of respiratory depression and profound sedation.
  • Alcohol and other CNS depressants: may cause excessive drowsiness or loss of coordination.
  • MAO inhibitors: potential for unpredictable CNS effects.

Moderate Interactions (Monitor Closely)

  • Diuretics: may increase serum Pregabalin concentrations.
  • Antihypertensives: additive hypotensive effect.
  • Anticholinergic agents: may exacerbate dry mouth and constipation.
  • NSAIDs: combined use may heighten risk of renal impairment in susceptible patients.

Frequently Asked Questions

Kartesada, containing pregabalin, is prescribed for neuropathic pain such as diabetic peripheral neuropathy and postherpetic neuralgia, for fibromyalgia to reduce widespread pain, and as an adjunctive therapy for partial onset seizures in adults.

Pregabalin binds to the α2‑δ subunit of voltage‑gated calcium channels in the central nervous system, decreasing calcium influx and consequently reducing the release of excitatory neurotransmitters that contribute to pain signaling and seizure activity.

The appropriate dose of Kartesada is determined by the prescribing clinician based on the individual’s medical condition, renal function, age, and response to therapy. Patients should follow the prescriber’s instructions and not adjust the dose on their own.

Pregabalin is classified as Pregnancy Category C, indicating that risk cannot be ruled out. It should only be used during pregnancy if the potential benefit justifies the potential risk. Limited data are available for breastfeeding; a decision should be made in consultation with a healthcare professional.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Kartesada’s active ingredient, pregabalin, shares a similar mechanism with gabapentin but generally offers higher potency, more predictable pharmacokinetics, and a lower dosing frequency. Clinical choice depends on individual patient response, tolerability, and specific regulatory approvals.

Store Kartesada at ambient temperature, preferably below 25 °C. Keep the tablets in the original packaging, protect them from moisture and direct sunlight, and ensure the container is tightly closed to maintain product stability.

Kartesada is taken orally, usually with or without food, as directed by the prescriber. Swallow the tablet whole with a glass of water; do not crush or chew unless specifically instructed.

Serious risks include angioedema, severe skin reactions, suicidal thoughts or behaviors, respiratory depression (especially when combined with CNS depressants), and rare blood disorders. Patients should seek immediate medical attention if they experience any of these symptoms.

Kartesada is contraindicated in patients with known hypersensitivity to pregabalin or any of the tablet’s excipients. Caution is also advised for individuals with severe renal impairment, uncontrolled epilepsy, or those taking prohibited concomitant CNS depressants without medical supervision.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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