Product image of Kartesada (Pregabalin) supplied by GNH India

Kartesada

Active Ingredient:
Pregabalin
Origin:
EU

Kartesada (Pregabalin)

Pregabalin, the active ingredient in Kartesada, is a gabapentinoid anticonvulsant presented as an oral tablet for oral use. It is indicated for neuropathic pain, partial seizures, fibromyalgia and generalized anxiety disorder in adult patients.
GNH India supplies Kartesada as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Neuraxpharm Bohemia S.R.O.

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Indications & Clinical Uses

Pregabalin acts on the nervous system to manage several chronic pain and seizure disorders.

  • Neuropathic pain: reduces pain intensity in diabetic peripheral neuropathy and post‑herpetic neuralgia.
  • Partial seizures (epilepsy): decreases seizure frequency in patients with focal onset seizures.
  • Fibromyalgia: alleviates widespread musculoskeletal pain and improves functional status.
  • Generalized anxiety disorder: lessens anxiety symptoms and improves overall mood.

How It Works

  • Pregabalin binds selectively to the α2‑δ subunit of voltage‑gated calcium channels in the central nervous system. This binding reduces calcium influx into presynaptic neurons, thereby decreasing the release of excitatory neurotransmitters such as glutamate, norepinephrine, and substance P, which modulates neuronal hyperexcitability associated with pain and seizures.

Side Effects

Adverse reactions may vary in frequency and severity.

Common Side Effects

  • Dizziness
  • Somnolence
  • Peripheral edema
  • Weight gain
  • Blurred vision
  • Dry mouth

Serious or Rare Side Effects

  • Angioedema or severe swelling
  • Stevens‑Johnson skin reactions
  • Suicidal thoughts or behavior
  • Respiratory depression when combined with CNS depressants
  • Severe hypersensitivity reactions
  • Hematologic abnormalities such as thrombocytopenia

Precautions & Warnings

Pregabalin requires careful assessment and monitoring in several clinical situations.

  • Assess renal function: dose adjustment may be needed in patients with impaired clearance.
  • Monitor for mood changes: watch for signs of depression or suicidal ideation.
  • Evaluate for edema: patients with heart failure may be at higher risk.
  • Caution in elderly: increased susceptibility to dizziness and falls.
  • Avoid abrupt discontinuation: taper under medical supervision to reduce withdrawal risk.
  • Store at ambient temperature below 25°C: keep in the original container, protect from moisture.

Avoid Interactions

Pregabalin can interact with other medicines, altering efficacy or safety.

Major Interactions (Avoid)

  • Opioid analgesics: heightened risk of respiratory depression and profound sedation.
  • Benzodiazepines: additive central nervous system depression leading to excessive drowsiness.
  • Antihypertensives: may potentiate hypotensive effects, causing dizziness or fainting.

Moderate Interactions (Monitor Closely)

  • Diuretics: can increase serum pregabalin concentrations, requiring dose review.
  • ACE inhibitors: may raise the likelihood of angioedema.
  • Antacids containing aluminum or magnesium: may modestly affect absorption, monitor therapeutic response.

Frequently Asked Questions

Kartesada, containing pregabalin, is prescribed for neuropathic pain such as diabetic peripheral neuropathy, for partial seizures in epilepsy, for the chronic pain syndrome of fibromyalgia, and for managing symptoms of generalized anxiety disorder in adults.

Pregabalin binds to the α2‑δ subunit of voltage‑gated calcium channels in the central nervous system, reducing calcium entry into nerve terminals. This limits the release of excitatory neurotransmitters, which helps dampen abnormal neuronal firing that underlies pain, seizures, and anxiety.

The specific dose of Kartesada is determined by the prescribing clinician based on the individual’s medical condition, response to therapy, renal function, and other factors. Patients should follow the dosage instructions provided by their healthcare professional.

Safety data for pregabalin in pregnancy and lactation are limited. It should only be used if the potential benefit justifies the potential risk to the fetus or infant, and the decision must be made by a qualified healthcare provider.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Kartesada contains the same active ingredient, pregabalin, as other branded or generic gabapentinoids. Its efficacy and safety profile are comparable, but differences may exist in formulation, excipients, and regulatory approvals, which can influence prescribing preferences and availability in specific markets.

Store Kartesada at ambient temperature below 25 °C. Keep the tablets in the original packaging, protect them from moisture and direct sunlight, and ensure the container is tightly closed to maintain product stability.

Kartesada is taken orally, usually with or without food, as directed by a healthcare professional. Swallow the tablet whole with a glass of water; do not crush, chew, or split the tablet unless specifically instructed.

Serious risks include severe allergic reactions such as angioedema, life‑threatening skin conditions like Stevens‑Johnson syndrome, suicidal thoughts or behaviors, and respiratory depression when combined with opioids or other central nervous system depressants. Prompt medical attention is required if any of these occur.

Kartesada is contraindicated in patients with known hypersensitivity to pregabalin or any of its excipients. Caution is advised for individuals with severe renal impairment, uncontrolled heart failure, or those taking medications that may cause dangerous additive CNS depression.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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