Product image of Kartesada (Pregabalin) supplied by GNH India

Kartesada

Active Ingredient:
Pregabalin
Origin:
EU

Kartesada (Pregabalin)

Pregabalin, the active ingredient in Kartesada, is an anticonvulsant presented as an oral tablet for systemic use. It is prescribed to manage neuropathic pain, partial seizures and generalized anxiety disorder in adult patients. The medication works by modulating calcium channel activity to reduce excitatory neurotransmitter release.

GNH India supplies Kartesada as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. Our distribution network ensures consistent quality and regulatory compliance across EU and global markets. We adhere to stringent quality standards and provide comprehensive documentation for each shipment.

Manufacturer / TM Owner

Neuraxpharm Bohemia S.R.O.

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Indications & Clinical Uses

  • Pregabalin is used to treat several neuropathic and seizure disorders by targeting abnormal neuronal excitability.
  • Diabetic peripheral neuropathic pain: reduces pain intensity and improves functional status.
  • Postherpetic neuralgia: alleviates burning and shooting pain after shingles.
  • Fibromyalgia: decreases widespread musculoskeletal pain and improves sleep quality.
  • Partial onset seizures: provides adjunctive control of focal seizures in adults.
  • Generalized anxiety disorder: lessens anxiety symptoms and improves daily functioning.

How It Works

  • Pregabalin binds selectively to the α2‑δ subunit of voltage‑gated calcium channels in the central nervous system. This binding reduces calcium influx into presynaptic neurons, decreasing the release of excitatory neurotransmitters such as glutamate, norepinephrine and substance P. The resulting attenuation of neuronal hyper‑excitability underlies its efficacy in neuropathic pain, seizure control and anxiety modulation.

Side Effects

Pregabalin may cause a range of adverse reactions, which are categorized by frequency and severity.

Common Side Effects

  • Dizziness
  • Somnolence
  • Peripheral edema
  • Weight gain
  • Dry mouth
  • Blurred vision

Serious or Rare Side Effects

  • Angioedema
  • Severe skin rash (e.g., Stevens‑Johnson syndrome)
  • Suicidal thoughts or behavior
  • Respiratory depression, especially when combined with other CNS depressants
  • Blood dyscrasias such as neutropenia
  • Anaphylactic reactions

Precautions & Warnings

  • When prescribing Pregabalin, clinicians should consider several safety precautions to minimize risk.
  • Renal impairment: adjust dose based on creatinine clearance.
  • Elderly patients: start at low dose and monitor for sedation.
  • Suicidal ideation: monitor for mood changes and emergent thoughts.
  • Pregnancy: category B, use only if benefit outweighs risk.
  • Concomitant CNS depressants: avoid excessive sedation or respiratory depression.
  • Driving and machinery: caution patients about impaired coordination.
  • Store at ambient temperature: keep in original container, protect from moisture and heat.

Avoid Interactions

Pregabalin can interact with other medicines, influencing its efficacy or safety profile.

Major Interactions (Avoid)

  • Opioids: combined use may cause profound respiratory depression and sedation.
  • Benzodiazepines or other CNS depressants: increased risk of profound drowsiness and impaired cognition.
  • Antidiabetic agents: may mask symptoms of hypoglycemia.

Moderate Interactions (Monitor Closely)

  • NSAIDs: may increase risk of peripheral edema.
  • Diuretics: monitor renal function and electrolyte balance.
  • Antihypertensives: possible additive blood pressure lowering.
  • Other antiepileptic drugs: may require dose adjustments.
  • MAO inhibitors: monitor for additive central nervous system effects.

Frequently Asked Questions

Kartesada, which contains pregabalin, is indicated for the management of diabetic peripheral neuropathic pain, postherpetic neuralgia, fibromyalgia, partial onset (focal) seizures, and generalized anxiety disorder in adult patients.

Pregabalin binds to the α2‑δ subunit of voltage‑gated calcium channels in the central nervous system, reducing calcium influx and consequently decreasing the release of excitatory neurotransmitters such as glutamate, norepinephrine and substance P. This dampens neuronal hyper‑excitability.

The appropriate dose of Kartesada is individualized by the prescribing clinician based on the specific indication, patient renal function, age, and response to therapy. No fixed regimen is provided here; the prescriber sets the dosage.

Pregabalin is classified as pregnancy category B, indicating that animal studies have not shown risk but adequate human data are lacking. It should be used only if the potential benefit justifies the potential risk to the fetus. Limited data are available for breastfeeding, so a risk‑benefit assessment is required.

To place an order, submit an enquiry on the Kartesada product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and import documentation.

Both pregabalin (Kartesada) and gabapentin bind to the α2‑δ calcium‑channel subunit, but pregabalin has higher binding affinity, more predictable pharmacokinetics, and generally requires fewer daily doses. Clinical efficacy is comparable for many neuropathic pain conditions, while individual tolerability may differ.

Store Kartesada at ambient temperature, preferably below 25 °C (77 °F). Keep the tablets in the original packaging, protect them from moisture, direct sunlight and excessive heat to maintain potency throughout the shelf life.

Kartesada is taken orally, usually with or without food, as directed by the prescriber. The tablets should be swallowed whole with a glass of water and not chewed or crushed unless specifically advised.

Serious adverse events include angioedema, severe skin reactions such as Stevens‑Johnson syndrome, suicidal thoughts or behaviors, and respiratory depression especially when combined with other central nervous system depressants. Patients should seek immediate medical attention if any of these occur.

Kartesada is contraindicated in patients with known hypersensitivity to pregabalin or any of the tablet excipients. Caution is also advised for individuals with severe renal impairment, uncontrolled psychiatric conditions, or those currently using multiple CNS depressants without close monitoring.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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