Product image of Kartesada (Pregabalin) supplied by GNH India

Kartesada

Active Ingredient:
Pregabalin
Origin:
EU

Kartesada (Pregabalin)

Pregabalin, the active ingredient in Kartesada, is a gabapentinoid presented as an oral tablet for oral administration. It modulates calcium channel activity and is used to treat neuropathic pain, partial seizures, and generalized anxiety disorder in adult patients.

GNH India supplies Kartesada as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, providing consistent quality and regulatory compliance for global healthcare providers. The product complies with European Union pharmaceutical standards and is widely distributed across multiple regions.

Manufacturer / TM Owner

Egis Pharmaceuticals Plc

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Indications & Clinical Uses

Pregabalin is used to manage several neurological and pain‑related conditions.

  • Diabetic peripheral neuropathy: reduces pain and improves sensory function in patients with diabetes‑related nerve damage.
  • Postherpetic neuralgia: alleviates lingering nerve pain following shingles.
  • Fibromyalgia: decreases widespread musculoskeletal pain and improves sleep quality.
  • Partial onset seizures: helps control focal seizures in epilepsy.
  • Generalized anxiety disorder: lessens anxiety symptoms and improves overall functioning.

How It Works

  • Pregabalin binds selectively to the α2‑δ subunit of voltage‑gated calcium channels in the central nervous system. This binding reduces calcium influx into presynaptic neurons, decreasing the release of excitatory neurotransmitters such as glutamate, norepinephrine, and substance P. The resulting modulation of neuronal hyper‑excitability underlies its analgesic, anticonvulsant, and anxiolytic effects. By stabilizing neuronal firing, pregabalin helps to control abnormal electrical activity associated with seizures and pain pathways.

Side Effects

Pregabalin may cause a range of adverse reactions, which are categorized by frequency and severity.

Common Side Effects

  • Dizziness: sensation of light‑headedness or unsteadiness.
  • Somnolence: increased sleepiness or fatigue.
  • Peripheral edema: swelling of the lower limbs.
  • Weight gain: gradual increase in body weight.

Serious or Rare Side Effects

  • Angioedema: rapid swelling of face, lips, tongue or throat.
  • Severe hypersensitivity: rash, Stevens‑Johnson syndrome, or toxic epidermal necrolysis.
  • Suicidal thoughts: emergence or worsening of suicidal ideation.

Precautions & Warnings

When prescribing or dispensing pregabalin, several precautions should be observed to ensure patient safety.

  • Renal impairment: adjust dose in patients with reduced kidney function.
  • Suicidality risk: monitor for depression, suicidal thoughts, especially during treatment initiation.
  • Pregnancy: avoid use unless potential benefit justifies potential risk to fetus.
  • Elderly patients: start with lower dose and monitor for dizziness and falls.
  • Concomitant CNS depressants: use caution as additive sedation may occur.
  • Store at ambient temperature: keep below 25 °C, in original container, protect from moisture.

Avoid Interactions

Pregabalin can interact with other medicines, affecting its efficacy or safety.

Major Interactions (Avoid)

  • Opioids: combined use may increase risk of respiratory depression and profound sedation.
  • CNS depressants (e.g., benzodiazepines, barbiturates): may cause excessive sedation or impaired cognition.

Moderate Interactions (Monitor Closely)

  • Antihypertensives: pregabalin may enhance hypotensive effects.
  • Diuretics: may increase risk of peripheral edema.
  • ACE inhibitors or ARBs: monitor renal function as combined effect may affect fluid balance.

Frequently Asked Questions

Kartesada contains pregabalin and is indicated for several neurological and pain‑related conditions, including diabetic peripheral neuropathy, postherpetic neuralgia, fibromyalgia, partial onset seizures, and generalized anxiety disorder. It is prescribed for adult patients when these conditions require pharmacologic management.

Pregabalin binds to the α2‑δ subunit of voltage‑gated calcium channels in the central nervous system. This reduces calcium entry into presynaptic neurons, which in turn lowers the release of excitatory neurotransmitters such as glutamate, norepinephrine, and substance P, helping to dampen neuronal hyper‑excitability.

The appropriate dose of Kartesada is determined by the prescribing clinician based on the individual’s medical condition, severity, renal function, age, and response to therapy. Dosage adjustments may be required for patients with impaired kidney function or for specific indications.

Safety data for pregabalin in pregnancy and lactation are limited. It should only be used when the potential benefit to the mother outweighs any possible risk to the fetus. Breastfeeding mothers should discuss potential exposure with their healthcare provider, as the drug can be excreted in breast milk.

To order Kartesada, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

The primary alternative to pregabalin is gabapentin, another gabapentinoid. Both share a similar mechanism of binding to the α2‑δ calcium‑channel subunit, but pregabalin generally has higher potency, more predictable pharmacokinetics, and may achieve therapeutic effects at lower doses compared with gabapentin.

Kartesada should be stored at ambient temperature, preferably below 25 °C. Keep the tablets in the original packaging, protect them from moisture and direct sunlight, and ensure the container is tightly closed to maintain product stability.

Kartesada is taken orally. Tablets should be swallowed whole with a glass of water and may be taken with or without food, as directed by the prescribing clinician. Patients should follow the prescribed schedule and not alter the dose without medical advice.

Serious risks include angioedema (rapid swelling of the face, lips, tongue, or throat), severe hypersensitivity reactions such as Stevens‑Johnson syndrome, and the emergence or worsening of suicidal thoughts or behaviors. Prompt medical attention is required if any of these events occur.

Kartesada is contraindicated in patients with known hypersensitivity to pregabalin or any of its excipients. Caution is advised for individuals with severe renal impairment, uncontrolled psychiatric conditions, or those taking multiple central nervous system depressants. The prescriber should evaluate each patient’s medical history before initiating therapy.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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